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Analiza razmene sestrinskih hromatida u kulturama limfocita čoveka tretiranih cimiazol hidrohloridom

dc.creatorStanimirović, Zoran
dc.creatorFišter, Svetlana L.
dc.creatorStevanović, Jevrosima
dc.date.accessioned2020-06-03T12:49:25Z
dc.date.available2020-06-03T12:49:25Z
dc.date.issued2003
dc.identifier.issn0567-8315
dc.identifier.urihttp://vet-erinar.vet.bg.ac.rs/handle/123456789/257
dc.description.abstractCymiazole hydrochloride is the active component of the acaricides Apitol® and Apichem®, which are used as varroacides in beekeeping. Considering that residues of cymiazole hydrochloride were detected in all bee products being used for human nutrition and as alternative medications in human and veterinary medicine, the aim of this study was to evaluate the ability of this substance to produce genotoxic effects in human peripheral blood lymphocytes. The genotoxic effects were studied by sister chromatid exchange (SCE) test in vitro. The results obtained for all doses applied to the cultures (0.01; 0.10 and 1 mg/ml) showed very significant increases in frequencies (p lt 0.001) of SCEs in comparison to the negative control, i.e. cymiazole hydrochloride exhibited genotoxic properties.en
dc.description.abstractCimiazol hidrohlorid je aktivna komponenta Apitol®-a i Apichem®-a koji se koriste kao varoacidi u gajenju pčela. Kako su rezidue cimiazol hidrohlorida utvrđene u svim pčelinjim proizvodima - kako onima koji se koriste u ljudskoj ishrani, tako i onima koji se koriste kao alternativni medikamenti u ljudskoj i veterinarskoj medicini, cilj ovog proučavanja je bio da se procene mogućnosti ove substance da izazove genotoksična dejstva na limfocite periferne krvi čoveka. Efekti genotoksičnosti ispitivani su u in vitro SCE testu. Dobijeni rezultati, za sve doze koje su primenjene u kulturama (0.01; 0.10 and 1 mg/ml), pokazali su statistički vrlo značajno povećanje (p lt 0.001) učestalosti SCEa u poređenju sa negativnom kontrolom tj. cimiazol hidrohlorid je, pri korišćenim uslovima eksperimenta, iskazao genotoksična svojstva u kulturi humanih limfocita.sr
dc.publisherUniverzitet u Beogradu - Fakultet veterinarske medicine, Beograd
dc.rightsopenAccess
dc.sourceActa veterinaria - Beograd
dc.subjectcymiazole hydrochlorideen
dc.subjectacaricidesen
dc.subjectvarroacidesen
dc.subjectpesticidesen
dc.subjectgenotoxicityen
dc.subjectSCE-testen
dc.subjectchromosomal aberrationsen
dc.subjectbeekeepingen
dc.titleAnalysis of sister-chromatid exchanges in cultured human lymphocytes treated with cymiazole hydrochlorideen
dc.titleAnaliza razmene sestrinskih hromatida u kulturama limfocita čoveka tretiranih cimiazol hidrohloridomsr
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСтевановић, Јевросима; Станимировић, Зоран; Фиштер, Светлана Л.; Aнализа размене сестринских хроматида у културама лимфоцита човека третираних цимиазол хидрохлоридом; Aнализа размене сестринских хроматида у културама лимфоцита човека третираних цимиазол хидрохлоридом;
dc.citation.volume53
dc.citation.issue5-6
dc.citation.spage419
dc.citation.epage426
dc.citation.other53(5-6): 419-426
dc.citation.rankM23
dc.identifier.wos000187620300015
dc.identifier.doi10.2298/AVB0306419S
dc.identifier.scopus2-s2.0-1642534319
dc.identifier.fulltexthttp://veterinar.vet.bg.ac.rs/bitstream/id/851/256.pdf
dc.identifier.rcubconv_591
dc.type.versionpublishedVersion


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