Synthesis and characterization of Cu(II), Cd(II), Pt(II), and Pd(II) complexes with condensation derivate of pyridine-2-carboxaldehyde and ethyl hydrazinoacetate

Abstract

In search for agents that might show less negative side effects and overcome the resistance to cisplatin, in this work a series of complexes of Cd(II), Cu(II), Pd(II) and Pt(II) with the condensation product of pyridine-2-carboxaldehyde and ethyl hydrazinoacetate were synthesized. All four complexes were obtained by template synthesis. Elemental analysis, molar conductivity, magnetic susceptibility (with Cu(II) complex), IR, 1 H NMR and 13C NMR spectral data showed that all the obtained complexes had a coordination number four. In the neutral square planar Pt(II), Pd(II) and Cd(II) complexes, the organic ligand is coordinated as a bidentate via pyridine and hydrazone nitrogen atoms, the remaining two coordination sites being occupied by chloride ion. In Cu(II) complex the ligand is coordinated as a tridentat, with chloride in the fourth coordination site, so that the geometry is tetrahedral, and the complex is 1 : 1 electrolyte.