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dc.creatorMilivojević, Marija
dc.creatorRadovanović, Željko
dc.creatorDimitrijević, Suzana
dc.creatorPetrović, Rada
dc.creatorMarković, Danica
dc.creatorJanaćković, Đorđe
dc.date.accessioned2023-03-14T13:22:55Z
dc.date.available2023-03-14T13:22:55Z
dc.date.issued2021
dc.identifier.isbn978-86-919111-6-4
dc.identifier.urihttps://vet-erinar.vet.bg.ac.rs/handle/123456789/2682
dc.description.abstractTissue engineering strategies for a treatment of large bone defects, which is currently implantation of bone grafts, are based on the development of biomaterials that mimic the bone tissue and improve regeneration. 3D printed macroporous titanium-based scaffolds, designed specifically for large bone defect implantation, provide both good mechanical support and architecture of pores suitable for ingrowth of bone tissue and better osseointegration. However, the bioinert surface of Ti6Al4V alloy is not the finest substrate for the growth of cells and mineral matrix deposition. The aim of this study was to modify the surface of the macroporous Ti scaffold, by coating it with multiple layers of bioceramics: silicate bioactive glasses (BAG) and Ag-doped calcium hydroxyapatite (AgHAP), in order to provide bioactivity, biocompatibility, and antibacterial properties. A dip-coating technique was optimized to provide a thin coating that is homogenous and uniform inside the porous structure of titanium samples, followed by its melting at optimized temperature to acquire a continuous BAG layer covered with AgHAP particles. The characterization of the synthesized bioceramic powders and surface morphology of specimen were conducted using scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy. The bioactivity was evaluated as the growth of hydroxyapatite crystals on the surface of the samples after 14 days in Simulated body fluid (SBF), which was determined using SEM. Biocompatibility of the obtained coatings and bare Ti samples was analyzed in vitro on the L929 cell line, applying the MTT test. Finally, the antibacterial properties of coated scaffolds were evaluated on E.coli, S. aureus, and C. albicans. Evaluation of the morphology of the coatings showed that the homogenous deposition was achieved by a dip-coating method. Improved bioactivity, biocompatibility, and antimicrobial properties of the coated scaffold showed the great potential of this approach for future clinical application.sr
dc.language.isoensr
dc.publisherBelgrade : Materials Research Society of Serbia, 2021sr
dc.rightsopenAccesssr
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceTwenty-second Annual Conference Yucomat 2021, Herceg Novi, August 30 - September 3, 2021sr
dc.titleImprovement of bioactivity, biocompatibility, and antibacterial properties of titanium scaffold by coating with bioactive glasses and Ag - doped HAPsr
dc.typeconferenceObjectsr
dc.rights.licenseBY-NC-NDsr
dc.citation.spage123
dc.citation.epage123
dc.identifier.fulltexthttp://veterinar.vet.bg.ac.rs/bitstream/id/7804/bitstream_7804.pdf
dc.identifier.rcubhttps://hdl.handle.net/21.15107/rcub_veterinar_2682
dc.type.versionpublishedVersionsr


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