Uticaj kompleksa Ru(II) na moguce puteve apoptoze u K562 celijama leukemije
Influence of Ru(II) complex on possible pathways of apoptosis in K562 leukemia cells
Authors
Krstić, MilenaSantibanez, Juan Francisco
Poljarević, Jelena
Nikolić, Stefan
Grguric-Šipka, Sanja R.
Borozan, Sunčica
Conference object (Published version)
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Show full item recordAbstract
U cilju pronalaženja adekvatne terapije u lecenju maligniteta kompleksi rutenijuma
pokazali su zavidan potencijal. Kompleksi Ru(II) sa N-alkilfenotiazinima,
hlorpromazinom, trifluoperazinom i tioridazinom, korišceni su u ispitivanju mogucih
puteva apoptoze u K562 celijama. Ispitivana je spektrofotometrijski ekstracelularna LDH,
ekspresija COX-2, t-JNK, p-JNK i b-aktina imunohemijski nakon SDS elektroforeze.
Kompleks Ru(II) sa trifluoperazinom u koncentraciji od 10 μM smanjuje ekspresiju t-JNK,
inhibira COX-2 oko 42%, znacajno povecava kolicinu ekstracelularne LDH u odnosu na
netretirane K562 celije i time potvrdjuje apoptozu ovih celija
Ruthenium complexes are of significant interest in the treatment of malignancies. Ru(II)
complexes with N-alkylphenothiazines (chlorpromazine, trifluoperazine, and thioridazine)
were used in the study of possible apoptosis pathways in K562 cells.
Spectrophotometrically extracellular LDH was quantified and immunochemical expression
of COX-2, t-JNK, p-JNK and b-actin after SDS electrophoresis was determined. The
Ru(II) complex with trifluoperazine at a concentration of 10 μM reduced t-JNK
expression, inhibited COX-2 by about 42%, significantly increased the amount of
extracellular LDH compared to the untreated K562 cells and thus confirmed apoptosis.
Source:
58. savetovanje Srpskog hemijskog društva, Beograd, 9 - 10. jun 2022., 2022, 89-89Publisher:
- Beograd : Razvojno-istraživački centar grafičkog inženjerstva TMF
Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200143 (University of Belgrade, Faculty of Veterinary Medicine) (RS-MESTD-inst-2020-200143)
Note:
- Kratki izvodi radova
Collections
Institution/Community
Fakultet veterinarske medicineTY - CONF AU - Krstić, Milena AU - Santibanez, Juan Francisco AU - Poljarević, Jelena AU - Nikolić, Stefan AU - Grguric-Šipka, Sanja R. AU - Borozan, Sunčica PY - 2022 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2797 AB - U cilju pronalaženja adekvatne terapije u lecenju maligniteta kompleksi rutenijuma pokazali su zavidan potencijal. Kompleksi Ru(II) sa N-alkilfenotiazinima, hlorpromazinom, trifluoperazinom i tioridazinom, korišceni su u ispitivanju mogucih puteva apoptoze u K562 celijama. Ispitivana je spektrofotometrijski ekstracelularna LDH, ekspresija COX-2, t-JNK, p-JNK i b-aktina imunohemijski nakon SDS elektroforeze. Kompleks Ru(II) sa trifluoperazinom u koncentraciji od 10 μM smanjuje ekspresiju t-JNK, inhibira COX-2 oko 42%, znacajno povecava kolicinu ekstracelularne LDH u odnosu na netretirane K562 celije i time potvrdjuje apoptozu ovih celija AB - Ruthenium complexes are of significant interest in the treatment of malignancies. Ru(II) complexes with N-alkylphenothiazines (chlorpromazine, trifluoperazine, and thioridazine) were used in the study of possible apoptosis pathways in K562 cells. Spectrophotometrically extracellular LDH was quantified and immunochemical expression of COX-2, t-JNK, p-JNK and b-actin after SDS electrophoresis was determined. The Ru(II) complex with trifluoperazine at a concentration of 10 μM reduced t-JNK expression, inhibited COX-2 by about 42%, significantly increased the amount of extracellular LDH compared to the untreated K562 cells and thus confirmed apoptosis. PB - Beograd : Razvojno-istraživački centar grafičkog inženjerstva TMF C3 - 58. savetovanje Srpskog hemijskog društva, Beograd, 9 - 10. jun 2022. T1 - Uticaj kompleksa Ru(II) na moguce puteve apoptoze u K562 celijama leukemije T1 - Influence of Ru(II) complex on possible pathways of apoptosis in K562 leukemia cells SP - 89 EP - 89 UR - https://hdl.handle.net/21.15107/rcub_veterinar_2797 ER -
@conference{ author = "Krstić, Milena and Santibanez, Juan Francisco and Poljarević, Jelena and Nikolić, Stefan and Grguric-Šipka, Sanja R. and Borozan, Sunčica", year = "2022", abstract = "U cilju pronalaženja adekvatne terapije u lecenju maligniteta kompleksi rutenijuma pokazali su zavidan potencijal. Kompleksi Ru(II) sa N-alkilfenotiazinima, hlorpromazinom, trifluoperazinom i tioridazinom, korišceni su u ispitivanju mogucih puteva apoptoze u K562 celijama. Ispitivana je spektrofotometrijski ekstracelularna LDH, ekspresija COX-2, t-JNK, p-JNK i b-aktina imunohemijski nakon SDS elektroforeze. Kompleks Ru(II) sa trifluoperazinom u koncentraciji od 10 μM smanjuje ekspresiju t-JNK, inhibira COX-2 oko 42%, znacajno povecava kolicinu ekstracelularne LDH u odnosu na netretirane K562 celije i time potvrdjuje apoptozu ovih celija, Ruthenium complexes are of significant interest in the treatment of malignancies. Ru(II) complexes with N-alkylphenothiazines (chlorpromazine, trifluoperazine, and thioridazine) were used in the study of possible apoptosis pathways in K562 cells. Spectrophotometrically extracellular LDH was quantified and immunochemical expression of COX-2, t-JNK, p-JNK and b-actin after SDS electrophoresis was determined. The Ru(II) complex with trifluoperazine at a concentration of 10 μM reduced t-JNK expression, inhibited COX-2 by about 42%, significantly increased the amount of extracellular LDH compared to the untreated K562 cells and thus confirmed apoptosis.", publisher = "Beograd : Razvojno-istraživački centar grafičkog inženjerstva TMF", journal = "58. savetovanje Srpskog hemijskog društva, Beograd, 9 - 10. jun 2022.", title = "Uticaj kompleksa Ru(II) na moguce puteve apoptoze u K562 celijama leukemije, Influence of Ru(II) complex on possible pathways of apoptosis in K562 leukemia cells", pages = "89-89", url = "https://hdl.handle.net/21.15107/rcub_veterinar_2797" }
Krstić, M., Santibanez, J. F., Poljarević, J., Nikolić, S., Grguric-Šipka, S. R.,& Borozan, S.. (2022). Uticaj kompleksa Ru(II) na moguce puteve apoptoze u K562 celijama leukemije. in 58. savetovanje Srpskog hemijskog društva, Beograd, 9 - 10. jun 2022. Beograd : Razvojno-istraživački centar grafičkog inženjerstva TMF., 89-89. https://hdl.handle.net/21.15107/rcub_veterinar_2797
Krstić M, Santibanez JF, Poljarević J, Nikolić S, Grguric-Šipka SR, Borozan S. Uticaj kompleksa Ru(II) na moguce puteve apoptoze u K562 celijama leukemije. in 58. savetovanje Srpskog hemijskog društva, Beograd, 9 - 10. jun 2022.. 2022;:89-89. https://hdl.handle.net/21.15107/rcub_veterinar_2797 .
Krstić, Milena, Santibanez, Juan Francisco, Poljarević, Jelena, Nikolić, Stefan, Grguric-Šipka, Sanja R., Borozan, Sunčica, "Uticaj kompleksa Ru(II) na moguce puteve apoptoze u K562 celijama leukemije" in 58. savetovanje Srpskog hemijskog društva, Beograd, 9 - 10. jun 2022. (2022):89-89, https://hdl.handle.net/21.15107/rcub_veterinar_2797 .