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Oxorhenium(V) complexes in the drug combination study
dc.creator | Petrović, Tamara | |
dc.creator | Gligorijević, Nevenka | |
dc.creator | Belaj, Ferdinand | |
dc.creator | Grgurić-Šipka, Sanja | |
dc.creator | Nikolić, Stefan | |
dc.creator | Krstić, Milena | |
dc.creator | Poljarević, Jelena | |
dc.creator | Mihajlović-Lalić, Ljiljana E. | |
dc.date.accessioned | 2023-03-27T10:47:00Z | |
dc.date.available | 2023-03-27T10:47:00Z | |
dc.date.issued | 2022 | |
dc.identifier.uri | https://vet-erinar.vet.bg.ac.rs/handle/123456789/2798 | |
dc.description.abstract | Rhenium complexes merit particular attention in the area of metallodrug design due to rhenium’s broad spectrum of oxidation states and consequently, the possibility to design compounds of a great structural diversity. Thus, the synthesis, chemical characterization and antitumor activity in vitro of the three Re(V) complexes is described. Novel compounds were obtained via reaction of [ReOCl3(PPh3)2] with corresponding ligands (pyridine-2-carboxylic acid, 3-methylpyridine-2-carboxylic acid and 6-methylpyridine- 2-carboxylic acid) in acetonitrile at 78 °C for 3h. The complexes were fully characterized using NMR, IR, MS and elemental analysis. Their octahedral geometry with bidentate N^O ligand was confirmed by X-ray diffraction analysis. Antiproliferative effect was determined by MTT assay and only the complex with pyridine-2-carboxylic acid (1) showed dose-dependent cytotoxic potential, particularly toward triple-negative breast adenocarcinoma cells MDA-MB-231 with IC50 68.90 ± 1.73 μM and pancreatic adenocarcinoma cells PANC-1 with IC50 69.8 ± 2.3 μM. Drug combination studies in PANC-1 cells with 1 and Verapamil hydrochloride (VRP) showed slight arrest of cell cycle in the S phase and also it increase its antiproliferative potential to IC50 51.4 ± 2.8 μM. Part of the research included a depletion of the glutathione (GSH) level by L-buthionine-sulfoximine (L-BSO) at sub-toxic concentrations (100 μM) in PANC-1 cells which caused an increase of activity of 1 to the IC50 57.67 ± 6.51 μM. | sr |
dc.language.iso | en | sr |
dc.rights | openAccess | sr |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Osterreichische Chemietage, Wienna, Austria, September 20-22, 2022 | sr |
dc.title | Oxorhenium(V) complexes in the drug combination study | sr |
dc.type | conferenceObject | sr |
dc.rights.license | BY | sr |
dc.citation.spage | 90 | |
dc.citation.epage | 90 | |
dc.description.other | Book of Abstracts | sr |
dc.identifier.fulltext | http://veterinar.vet.bg.ac.rs/bitstream/id/8187/bitstream_8187.pdf | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_veterinar_2798 | |
dc.type.version | publishedVersion | sr |