Maternal subclinical and clinical hypothyroidism effects on rat offspring: a story of the skin and its derivatives
Аутори
Lužajić Božinovski, TijanaDanilović Luković, Jelena
Nikolić, Anja
Radovanović, Anita
Marković, Danica
Kovačević Filipović, Milica
Vasić, Mirjana
Milošević, Ivan
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Epidermis stem cells have a crucial role through the processes of proliferation and
differentiation, to replace cells that are constantly lost during tissue turnover or
following injury. On the other hand, thyroid hormones regulate the proliferation and
differentiation of epidermal cells and thus significantly influence the homeostasis
of the skin. It is well known that maternal hypothyroidism during pregnancy leads
to impaired development of many organ systems in their offspring. However, there
is a lack of data about the influence of maternal subclinical hypothyroidism during
pregnancy and lactation on the development of the skin and its derivatives in the litter.
The aim of this study was to investigate the effects of maternal thyroid dysfunction on
the development of the skin and its derivatives in their offspring in the early postnatal
period. Antithyroid substance 6-n-propyl-2-thiouracil was added into the drinking water
to female Albino Oxfords rats from the beginning... of pregnancy and during lactation,
with the aim to induce subclinical and overt form of hypothyroidism. Skin samples
were taken from male pups within twenty-four hours and seven days after birth. The
main findings of this investigation were that both forms of maternal hypothyroidism
lead to serious damage of the epidermis in pups in terms of pronounced hyperkeratosis
and reduction of the germinal layer along with a reduced number of hair follicles and
their delayed morphogenesis. Epidermal impairments were more pronounced in pups
with the overt form of hypothyroidism while offspring with the subclinical form had
impairments that were less pronounced and delayed in occurrence.
Кључне речи:
apoptosis / hair follicle bulge / pluripotency / proliferation / regeneration / NanogИзвор:
Acta Veterinaria, 2023, 73, 2, 231-248Издавач:
- Beograd : Fakultet veterinarske medicine
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200143 (Универзитет у Београду, Факултет ветеринарске медицине) (RS-MESTD-inst-2020-200143)
Колекције
Институција/група
Fakultet veterinarske medicineTY - JOUR AU - Lužajić Božinovski, Tijana AU - Danilović Luković, Jelena AU - Nikolić, Anja AU - Radovanović, Anita AU - Marković, Danica AU - Kovačević Filipović, Milica AU - Vasić, Mirjana AU - Milošević, Ivan PY - 2023 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/3047 AB - Epidermis stem cells have a crucial role through the processes of proliferation and differentiation, to replace cells that are constantly lost during tissue turnover or following injury. On the other hand, thyroid hormones regulate the proliferation and differentiation of epidermal cells and thus significantly influence the homeostasis of the skin. It is well known that maternal hypothyroidism during pregnancy leads to impaired development of many organ systems in their offspring. However, there is a lack of data about the influence of maternal subclinical hypothyroidism during pregnancy and lactation on the development of the skin and its derivatives in the litter. The aim of this study was to investigate the effects of maternal thyroid dysfunction on the development of the skin and its derivatives in their offspring in the early postnatal period. Antithyroid substance 6-n-propyl-2-thiouracil was added into the drinking water to female Albino Oxfords rats from the beginning of pregnancy and during lactation, with the aim to induce subclinical and overt form of hypothyroidism. Skin samples were taken from male pups within twenty-four hours and seven days after birth. The main findings of this investigation were that both forms of maternal hypothyroidism lead to serious damage of the epidermis in pups in terms of pronounced hyperkeratosis and reduction of the germinal layer along with a reduced number of hair follicles and their delayed morphogenesis. Epidermal impairments were more pronounced in pups with the overt form of hypothyroidism while offspring with the subclinical form had impairments that were less pronounced and delayed in occurrence. PB - Beograd : Fakultet veterinarske medicine T2 - Acta Veterinaria T1 - Maternal subclinical and clinical hypothyroidism effects on rat offspring: a story of the skin and its derivatives VL - 73 IS - 2 SP - 231 EP - 248 DO - 10.2478/acve-2023-0018 ER -
@article{ author = "Lužajić Božinovski, Tijana and Danilović Luković, Jelena and Nikolić, Anja and Radovanović, Anita and Marković, Danica and Kovačević Filipović, Milica and Vasić, Mirjana and Milošević, Ivan", year = "2023", abstract = "Epidermis stem cells have a crucial role through the processes of proliferation and differentiation, to replace cells that are constantly lost during tissue turnover or following injury. On the other hand, thyroid hormones regulate the proliferation and differentiation of epidermal cells and thus significantly influence the homeostasis of the skin. It is well known that maternal hypothyroidism during pregnancy leads to impaired development of many organ systems in their offspring. However, there is a lack of data about the influence of maternal subclinical hypothyroidism during pregnancy and lactation on the development of the skin and its derivatives in the litter. The aim of this study was to investigate the effects of maternal thyroid dysfunction on the development of the skin and its derivatives in their offspring in the early postnatal period. Antithyroid substance 6-n-propyl-2-thiouracil was added into the drinking water to female Albino Oxfords rats from the beginning of pregnancy and during lactation, with the aim to induce subclinical and overt form of hypothyroidism. Skin samples were taken from male pups within twenty-four hours and seven days after birth. The main findings of this investigation were that both forms of maternal hypothyroidism lead to serious damage of the epidermis in pups in terms of pronounced hyperkeratosis and reduction of the germinal layer along with a reduced number of hair follicles and their delayed morphogenesis. Epidermal impairments were more pronounced in pups with the overt form of hypothyroidism while offspring with the subclinical form had impairments that were less pronounced and delayed in occurrence.", publisher = "Beograd : Fakultet veterinarske medicine", journal = "Acta Veterinaria", title = "Maternal subclinical and clinical hypothyroidism effects on rat offspring: a story of the skin and its derivatives", volume = "73", number = "2", pages = "231-248", doi = "10.2478/acve-2023-0018" }
Lužajić Božinovski, T., Danilović Luković, J., Nikolić, A., Radovanović, A., Marković, D., Kovačević Filipović, M., Vasić, M.,& Milošević, I.. (2023). Maternal subclinical and clinical hypothyroidism effects on rat offspring: a story of the skin and its derivatives. in Acta Veterinaria Beograd : Fakultet veterinarske medicine., 73(2), 231-248. https://doi.org/10.2478/acve-2023-0018
Lužajić Božinovski T, Danilović Luković J, Nikolić A, Radovanović A, Marković D, Kovačević Filipović M, Vasić M, Milošević I. Maternal subclinical and clinical hypothyroidism effects on rat offspring: a story of the skin and its derivatives. in Acta Veterinaria. 2023;73(2):231-248. doi:10.2478/acve-2023-0018 .
Lužajić Božinovski, Tijana, Danilović Luković, Jelena, Nikolić, Anja, Radovanović, Anita, Marković, Danica, Kovačević Filipović, Milica, Vasić, Mirjana, Milošević, Ivan, "Maternal subclinical and clinical hypothyroidism effects on rat offspring: a story of the skin and its derivatives" in Acta Veterinaria, 73, no. 2 (2023):231-248, https://doi.org/10.2478/acve-2023-0018 . .