Evolutionarily diverse origins of deformed wing viruses in western honey bees
Аутори
Hasegawa, NonnoTecher, Maeva A.
Adjlane, Noureddine
Sabah al-Hissnawi, Muntasser
Antúnez, Karina
Beaurepaire, Alexis
Christmon, Krisztina
Delatte, Helene
Dukku, Usman H.
Eliash, Nurit
El-Niweiri, Mogbel A. A
Esnault, Olivier
Evans, Jay D.
Haddad, Nizar J.
Locke, Barbara
Muñoz, Irene
Noël, Grégoire
Panziera, Delphine
Roberts, John M. K.
De la Rúa, Pilar
Shebl, Mohamed A.
Stanimirović, Zoran
Rasmussen, David A.
Mikheyev, Alexander S.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Novel transmission routes can allow infectious diseases to spread, often with devastating consequences. Ectoparasitic varroa mites vector a diversity of RNA viruses, having switched hosts from the eastern to western honey bees (Apis cerana to Apis mellifera). They provide an opportunity to explore how novel transmission routes shape disease epidemiology. As the principal driver of the spread of deformed wing viruses (mainly DWV-A and DWV-B), varroa infestation has also driven global honey bee health declines. The more virulent DWV-B strain has been replacing the original DWV-A strain in many regions over the past two decades. Yet, how these viruses originated and spread remains poorly understood. Here, we use a phylogeographic analysis based on whole-genome data to reconstruct the origins and demography of DWV spread. We found that, rather than reemerging in western honey bees after varroa switched hosts, as suggested by previous work, DWV-A most likely originated in East Asia and spre...ad in the mid-20th century. It also showed a massive population size expansion following the varroa host switch. By contrast, DWV-B was most likely acquired more recently from a source outside East Asia and appears absent from the original varroa host. These results highlight the dynamic nature of viral adaptation, whereby a vector's host switch can give rise to competing and increasingly virulent disease pandemics. The evolutionary novelty and rapid global spread of these host-virus interactions, together with observed spillover into other species, illustrate how increasing globalization poses urgent threats to biodiversity and food security.
Кључне речи:
varroa / single-stranded RNA viruses / apis / phylogeographyИзвор:
Proceedings of the National Academy of Sciences (PNAS), 2023, 120, 26, 2301258120-Издавач:
- National Academy of Sciences
Финансирање / пројекти:
- Future Fellowship from the Australian Research Council (FT160100178)
- Kakenhi Grant-in-Aid for Scientific Research from the JSPS (Japan Society for Promotion of Science) (18H02216)
- M.A.T.’s research was supported by a postdoctoral fellowship from the JSPS (P19723)
- Kakenhi Grant-in-Aid (19F19723)
Колекције
Институција/група
Fakultet veterinarske medicineTY - JOUR AU - Hasegawa, Nonno AU - Techer, Maeva A. AU - Adjlane, Noureddine AU - Sabah al-Hissnawi, Muntasser AU - Antúnez, Karina AU - Beaurepaire, Alexis AU - Christmon, Krisztina AU - Delatte, Helene AU - Dukku, Usman H. AU - Eliash, Nurit AU - El-Niweiri, Mogbel A. A AU - Esnault, Olivier AU - Evans, Jay D. AU - Haddad, Nizar J. AU - Locke, Barbara AU - Muñoz, Irene AU - Noël, Grégoire AU - Panziera, Delphine AU - Roberts, John M. K. AU - De la Rúa, Pilar AU - Shebl, Mohamed A. AU - Stanimirović, Zoran AU - Rasmussen, David A. AU - Mikheyev, Alexander S. PY - 2023 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/3146 AB - Novel transmission routes can allow infectious diseases to spread, often with devastating consequences. Ectoparasitic varroa mites vector a diversity of RNA viruses, having switched hosts from the eastern to western honey bees (Apis cerana to Apis mellifera). They provide an opportunity to explore how novel transmission routes shape disease epidemiology. As the principal driver of the spread of deformed wing viruses (mainly DWV-A and DWV-B), varroa infestation has also driven global honey bee health declines. The more virulent DWV-B strain has been replacing the original DWV-A strain in many regions over the past two decades. Yet, how these viruses originated and spread remains poorly understood. Here, we use a phylogeographic analysis based on whole-genome data to reconstruct the origins and demography of DWV spread. We found that, rather than reemerging in western honey bees after varroa switched hosts, as suggested by previous work, DWV-A most likely originated in East Asia and spread in the mid-20th century. It also showed a massive population size expansion following the varroa host switch. By contrast, DWV-B was most likely acquired more recently from a source outside East Asia and appears absent from the original varroa host. These results highlight the dynamic nature of viral adaptation, whereby a vector's host switch can give rise to competing and increasingly virulent disease pandemics. The evolutionary novelty and rapid global spread of these host-virus interactions, together with observed spillover into other species, illustrate how increasing globalization poses urgent threats to biodiversity and food security. PB - National Academy of Sciences T2 - Proceedings of the National Academy of Sciences (PNAS) T1 - Evolutionarily diverse origins of deformed wing viruses in western honey bees VL - 120 IS - 26 SP - 2301258120 DO - 10.1073/pnas.2301258120 ER -
@article{ author = "Hasegawa, Nonno and Techer, Maeva A. and Adjlane, Noureddine and Sabah al-Hissnawi, Muntasser and Antúnez, Karina and Beaurepaire, Alexis and Christmon, Krisztina and Delatte, Helene and Dukku, Usman H. and Eliash, Nurit and El-Niweiri, Mogbel A. A and Esnault, Olivier and Evans, Jay D. and Haddad, Nizar J. and Locke, Barbara and Muñoz, Irene and Noël, Grégoire and Panziera, Delphine and Roberts, John M. K. and De la Rúa, Pilar and Shebl, Mohamed A. and Stanimirović, Zoran and Rasmussen, David A. and Mikheyev, Alexander S.", year = "2023", abstract = "Novel transmission routes can allow infectious diseases to spread, often with devastating consequences. Ectoparasitic varroa mites vector a diversity of RNA viruses, having switched hosts from the eastern to western honey bees (Apis cerana to Apis mellifera). They provide an opportunity to explore how novel transmission routes shape disease epidemiology. As the principal driver of the spread of deformed wing viruses (mainly DWV-A and DWV-B), varroa infestation has also driven global honey bee health declines. The more virulent DWV-B strain has been replacing the original DWV-A strain in many regions over the past two decades. Yet, how these viruses originated and spread remains poorly understood. Here, we use a phylogeographic analysis based on whole-genome data to reconstruct the origins and demography of DWV spread. We found that, rather than reemerging in western honey bees after varroa switched hosts, as suggested by previous work, DWV-A most likely originated in East Asia and spread in the mid-20th century. It also showed a massive population size expansion following the varroa host switch. By contrast, DWV-B was most likely acquired more recently from a source outside East Asia and appears absent from the original varroa host. These results highlight the dynamic nature of viral adaptation, whereby a vector's host switch can give rise to competing and increasingly virulent disease pandemics. The evolutionary novelty and rapid global spread of these host-virus interactions, together with observed spillover into other species, illustrate how increasing globalization poses urgent threats to biodiversity and food security.", publisher = "National Academy of Sciences", journal = "Proceedings of the National Academy of Sciences (PNAS)", title = "Evolutionarily diverse origins of deformed wing viruses in western honey bees", volume = "120", number = "26", pages = "2301258120", doi = "10.1073/pnas.2301258120" }
Hasegawa, N., Techer, M. A., Adjlane, N., Sabah al-Hissnawi, M., Antúnez, K., Beaurepaire, A., Christmon, K., Delatte, H., Dukku, U. H., Eliash, N., El-Niweiri, M. A. A., Esnault, O., Evans, J. D., Haddad, N. J., Locke, B., Muñoz, I., Noël, G., Panziera, D., Roberts, J. M. K., De la Rúa, P., Shebl, M. A., Stanimirović, Z., Rasmussen, D. A.,& Mikheyev, A. S.. (2023). Evolutionarily diverse origins of deformed wing viruses in western honey bees. in Proceedings of the National Academy of Sciences (PNAS) National Academy of Sciences., 120(26), 2301258120. https://doi.org/10.1073/pnas.2301258120
Hasegawa N, Techer MA, Adjlane N, Sabah al-Hissnawi M, Antúnez K, Beaurepaire A, Christmon K, Delatte H, Dukku UH, Eliash N, El-Niweiri MAA, Esnault O, Evans JD, Haddad NJ, Locke B, Muñoz I, Noël G, Panziera D, Roberts JMK, De la Rúa P, Shebl MA, Stanimirović Z, Rasmussen DA, Mikheyev AS. Evolutionarily diverse origins of deformed wing viruses in western honey bees. in Proceedings of the National Academy of Sciences (PNAS). 2023;120(26):2301258120. doi:10.1073/pnas.2301258120 .
Hasegawa, Nonno, Techer, Maeva A., Adjlane, Noureddine, Sabah al-Hissnawi, Muntasser, Antúnez, Karina, Beaurepaire, Alexis, Christmon, Krisztina, Delatte, Helene, Dukku, Usman H., Eliash, Nurit, El-Niweiri, Mogbel A. A, Esnault, Olivier, Evans, Jay D., Haddad, Nizar J., Locke, Barbara, Muñoz, Irene, Noël, Grégoire, Panziera, Delphine, Roberts, John M. K., De la Rúa, Pilar, Shebl, Mohamed A., Stanimirović, Zoran, Rasmussen, David A., Mikheyev, Alexander S., "Evolutionarily diverse origins of deformed wing viruses in western honey bees" in Proceedings of the National Academy of Sciences (PNAS), 120, no. 26 (2023):2301258120, https://doi.org/10.1073/pnas.2301258120 . .