The effect of pharmacologically active compounds from Ginkgo bilobae extract on contractility of rabbit duodenum and ileum
Uticaj farmakološki aktivnih jedinjenja iz ekstrakta Ginkgo bilobae na kontraktilnost duodenuma i ileuma kunića
2005
Аутори
Pilija, VladimirDraganić-Gajić, Saveta
Savović, Slobodan
Mihalj, Marija
Zgonjanin, Dragana M.
Jovanović, Ivan B.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Findings that there are pharmacologically active compounds in the Ginkgo bilobae extract recently provoked numerous investigations of their action on the receptors of the autonomous nervous system. The purpose of the present study was to determine the influence of gingko extract on the contractility of the longitudinal smooth muscle layer in the wall of the rabbit duodenum and ileum using the method of Magnus. Results clearly show that gingko extract causes a dose dependent tonus decrease of duodenal and Heal smooth muscles in the rabbit. It also reduces the stimulation of spontaneous activity of smooth muscles caused by acetylcholine, the reduction being greater in ileum compared to duodenum.
Biohemijska saznanja o prisustvu farmakološki aktivnih jedinjenja iz ekstrakta Ginkgo bilobae, dala su nov podstrek za izučavanje njihovog dejstva na receptore autonomnog nervnog sistema. Otuda je cilj našeg istraživanja bio da se ispita uticaj ekstrakta ove biljke na kontraktilnost glatkomišićnog sloja u zidu duodenuma i ileuma kunića metodom po Magnus-u. Rezultati Istraživanja ukazuju da ispitivani ekstrakt izaziva dozno-zavisno sniženje tonusa longitudinalne glatke muskulature duodenuma i ileuma, kao i da redukuje acetilholinom izazvanu stimulaciju spontane aktivnosti duodenuma i ileuma.
Кључне речи:
Ginko bilobae extract / duodenum / ileum / smooth muscle tonus / acetylcholineИзвор:
Acta Veterinaria-Beograd, 2005, 55, 2-3, 245-250Издавач:
- Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
DOI: 10.2298/AVB0503245P
ISSN: 0567-8315
WoS: 000229817500016
Scopus: 2-s2.0-21344442862
Колекције
Институција/група
Fakultet veterinarske medicineTY - JOUR AU - Pilija, Vladimir AU - Draganić-Gajić, Saveta AU - Savović, Slobodan AU - Mihalj, Marija AU - Zgonjanin, Dragana M. AU - Jovanović, Ivan B. PY - 2005 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/314 AB - Findings that there are pharmacologically active compounds in the Ginkgo bilobae extract recently provoked numerous investigations of their action on the receptors of the autonomous nervous system. The purpose of the present study was to determine the influence of gingko extract on the contractility of the longitudinal smooth muscle layer in the wall of the rabbit duodenum and ileum using the method of Magnus. Results clearly show that gingko extract causes a dose dependent tonus decrease of duodenal and Heal smooth muscles in the rabbit. It also reduces the stimulation of spontaneous activity of smooth muscles caused by acetylcholine, the reduction being greater in ileum compared to duodenum. AB - Biohemijska saznanja o prisustvu farmakološki aktivnih jedinjenja iz ekstrakta Ginkgo bilobae, dala su nov podstrek za izučavanje njihovog dejstva na receptore autonomnog nervnog sistema. Otuda je cilj našeg istraživanja bio da se ispita uticaj ekstrakta ove biljke na kontraktilnost glatkomišićnog sloja u zidu duodenuma i ileuma kunića metodom po Magnus-u. Rezultati Istraživanja ukazuju da ispitivani ekstrakt izaziva dozno-zavisno sniženje tonusa longitudinalne glatke muskulature duodenuma i ileuma, kao i da redukuje acetilholinom izazvanu stimulaciju spontane aktivnosti duodenuma i ileuma. PB - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd T2 - Acta Veterinaria-Beograd T1 - The effect of pharmacologically active compounds from Ginkgo bilobae extract on contractility of rabbit duodenum and ileum T1 - Uticaj farmakološki aktivnih jedinjenja iz ekstrakta Ginkgo bilobae na kontraktilnost duodenuma i ileuma kunića VL - 55 IS - 2-3 SP - 245 EP - 250 DO - 10.2298/AVB0503245P ER -
@article{ author = "Pilija, Vladimir and Draganić-Gajić, Saveta and Savović, Slobodan and Mihalj, Marija and Zgonjanin, Dragana M. and Jovanović, Ivan B.", year = "2005", abstract = "Findings that there are pharmacologically active compounds in the Ginkgo bilobae extract recently provoked numerous investigations of their action on the receptors of the autonomous nervous system. The purpose of the present study was to determine the influence of gingko extract on the contractility of the longitudinal smooth muscle layer in the wall of the rabbit duodenum and ileum using the method of Magnus. Results clearly show that gingko extract causes a dose dependent tonus decrease of duodenal and Heal smooth muscles in the rabbit. It also reduces the stimulation of spontaneous activity of smooth muscles caused by acetylcholine, the reduction being greater in ileum compared to duodenum., Biohemijska saznanja o prisustvu farmakološki aktivnih jedinjenja iz ekstrakta Ginkgo bilobae, dala su nov podstrek za izučavanje njihovog dejstva na receptore autonomnog nervnog sistema. Otuda je cilj našeg istraživanja bio da se ispita uticaj ekstrakta ove biljke na kontraktilnost glatkomišićnog sloja u zidu duodenuma i ileuma kunića metodom po Magnus-u. Rezultati Istraživanja ukazuju da ispitivani ekstrakt izaziva dozno-zavisno sniženje tonusa longitudinalne glatke muskulature duodenuma i ileuma, kao i da redukuje acetilholinom izazvanu stimulaciju spontane aktivnosti duodenuma i ileuma.", publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd", journal = "Acta Veterinaria-Beograd", title = "The effect of pharmacologically active compounds from Ginkgo bilobae extract on contractility of rabbit duodenum and ileum, Uticaj farmakološki aktivnih jedinjenja iz ekstrakta Ginkgo bilobae na kontraktilnost duodenuma i ileuma kunića", volume = "55", number = "2-3", pages = "245-250", doi = "10.2298/AVB0503245P" }
Pilija, V., Draganić-Gajić, S., Savović, S., Mihalj, M., Zgonjanin, D. M.,& Jovanović, I. B.. (2005). The effect of pharmacologically active compounds from Ginkgo bilobae extract on contractility of rabbit duodenum and ileum. in Acta Veterinaria-Beograd Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 55(2-3), 245-250. https://doi.org/10.2298/AVB0503245P
Pilija V, Draganić-Gajić S, Savović S, Mihalj M, Zgonjanin DM, Jovanović IB. The effect of pharmacologically active compounds from Ginkgo bilobae extract on contractility of rabbit duodenum and ileum. in Acta Veterinaria-Beograd. 2005;55(2-3):245-250. doi:10.2298/AVB0503245P .
Pilija, Vladimir, Draganić-Gajić, Saveta, Savović, Slobodan, Mihalj, Marija, Zgonjanin, Dragana M., Jovanović, Ivan B., "The effect of pharmacologically active compounds from Ginkgo bilobae extract on contractility of rabbit duodenum and ileum" in Acta Veterinaria-Beograd, 55, no. 2-3 (2005):245-250, https://doi.org/10.2298/AVB0503245P . .