Antiparsitic effect of some active components of essential oils
Аутори
Marjanović, ĐorđeZdravković, Nemanja
Pavlović, Marija
Nešić, Ksenija
Savić Radovanović, Radoslava
Trailović, Saša
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Introduction: Modern antiparasitic pharmacotherapy faces several important challenges. An
increasing number of reports refer to the resistance of parasitic nematodes to conventional
antiparasitic drugs, while dose increasing manifests their toxicity. Particularly important for
veterinary medicine is the fact that most antiparasitic drugs require a long withdrawal period
after application in animals whose tissues are intended for human consumption.
Aims: To examine the potential antinematodic effect of selected monoterpenoid and
diterpenoid active principles of essential vegetable oils and determine the mechanism by
which they achieve antiparasitic effects.
Materials and Methods: Investigation of the interaction of active principles of essential
vegetable oils with cholinergic and GABA-ergic nematode receptors on neuromuscular
preparation Ascaris suum and Caenorhabidis elegans culture.
Results: The terpenoids alpha-pinene, p-cymene, carveol, carnosol and cinnamaldehy...de do
not show any pharmacological effects on the contractions of the neuromuscular preparation A.
suum. The monoterpenoid carvacrol exhibits the properties of the competitive / noncompetitive nicotinic acetylcholine receptor (nAChR) antagonist A. suum and effectively and
significantly inhibits neuromuscular contractions caused by increasing acetylcholine
concentrations. - carvacrol does not alter the EC50 value of acetylcholine The tested active
principles of essential oils in our tests showed a specific and unique mechanism of action that
potentially enables them high efficacy, even in nematodes resistant to classical anthelmintics.
Conclusion: Based on our results, carvacrol, carveol, menthol and thymol are very serious
candidates for independent use in antinematode therapy or use in combination with drugs
agonists of GABA receptor nematodes.
Кључне речи:
Ascaris suum / Caenorhabidis elegans / GABAИзвор:
19th International Conference Life Sciences for Sustainable Development, Cluj-Napoca, Romania, 24th - 25th September 2020, 2020, 287-287Издавач:
- University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca
Напомена:
- Book og abstracts
Колекције
Институција/група
Fakultet veterinarske medicineTY - CONF AU - Marjanović, Đorđe AU - Zdravković, Nemanja AU - Pavlović, Marija AU - Nešić, Ksenija AU - Savić Radovanović, Radoslava AU - Trailović, Saša PY - 2020 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/3311 AB - Introduction: Modern antiparasitic pharmacotherapy faces several important challenges. An increasing number of reports refer to the resistance of parasitic nematodes to conventional antiparasitic drugs, while dose increasing manifests their toxicity. Particularly important for veterinary medicine is the fact that most antiparasitic drugs require a long withdrawal period after application in animals whose tissues are intended for human consumption. Aims: To examine the potential antinematodic effect of selected monoterpenoid and diterpenoid active principles of essential vegetable oils and determine the mechanism by which they achieve antiparasitic effects. Materials and Methods: Investigation of the interaction of active principles of essential vegetable oils with cholinergic and GABA-ergic nematode receptors on neuromuscular preparation Ascaris suum and Caenorhabidis elegans culture. Results: The terpenoids alpha-pinene, p-cymene, carveol, carnosol and cinnamaldehyde do not show any pharmacological effects on the contractions of the neuromuscular preparation A. suum. The monoterpenoid carvacrol exhibits the properties of the competitive / noncompetitive nicotinic acetylcholine receptor (nAChR) antagonist A. suum and effectively and significantly inhibits neuromuscular contractions caused by increasing acetylcholine concentrations. - carvacrol does not alter the EC50 value of acetylcholine The tested active principles of essential oils in our tests showed a specific and unique mechanism of action that potentially enables them high efficacy, even in nematodes resistant to classical anthelmintics. Conclusion: Based on our results, carvacrol, carveol, menthol and thymol are very serious candidates for independent use in antinematode therapy or use in combination with drugs agonists of GABA receptor nematodes. PB - University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca C3 - 19th International Conference Life Sciences for Sustainable Development, Cluj-Napoca, Romania, 24th - 25th September 2020 T1 - Antiparsitic effect of some active components of essential oils SP - 287 EP - 287 UR - https://hdl.handle.net/21.15107/rcub_veterinar_3311 ER -
@conference{ author = "Marjanović, Đorđe and Zdravković, Nemanja and Pavlović, Marija and Nešić, Ksenija and Savić Radovanović, Radoslava and Trailović, Saša", year = "2020", abstract = "Introduction: Modern antiparasitic pharmacotherapy faces several important challenges. An increasing number of reports refer to the resistance of parasitic nematodes to conventional antiparasitic drugs, while dose increasing manifests their toxicity. Particularly important for veterinary medicine is the fact that most antiparasitic drugs require a long withdrawal period after application in animals whose tissues are intended for human consumption. Aims: To examine the potential antinematodic effect of selected monoterpenoid and diterpenoid active principles of essential vegetable oils and determine the mechanism by which they achieve antiparasitic effects. Materials and Methods: Investigation of the interaction of active principles of essential vegetable oils with cholinergic and GABA-ergic nematode receptors on neuromuscular preparation Ascaris suum and Caenorhabidis elegans culture. Results: The terpenoids alpha-pinene, p-cymene, carveol, carnosol and cinnamaldehyde do not show any pharmacological effects on the contractions of the neuromuscular preparation A. suum. The monoterpenoid carvacrol exhibits the properties of the competitive / noncompetitive nicotinic acetylcholine receptor (nAChR) antagonist A. suum and effectively and significantly inhibits neuromuscular contractions caused by increasing acetylcholine concentrations. - carvacrol does not alter the EC50 value of acetylcholine The tested active principles of essential oils in our tests showed a specific and unique mechanism of action that potentially enables them high efficacy, even in nematodes resistant to classical anthelmintics. Conclusion: Based on our results, carvacrol, carveol, menthol and thymol are very serious candidates for independent use in antinematode therapy or use in combination with drugs agonists of GABA receptor nematodes.", publisher = "University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca", journal = "19th International Conference Life Sciences for Sustainable Development, Cluj-Napoca, Romania, 24th - 25th September 2020", title = "Antiparsitic effect of some active components of essential oils", pages = "287-287", url = "https://hdl.handle.net/21.15107/rcub_veterinar_3311" }
Marjanović, Đ., Zdravković, N., Pavlović, M., Nešić, K., Savić Radovanović, R.,& Trailović, S.. (2020). Antiparsitic effect of some active components of essential oils. in 19th International Conference Life Sciences for Sustainable Development, Cluj-Napoca, Romania, 24th - 25th September 2020 University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca., 287-287. https://hdl.handle.net/21.15107/rcub_veterinar_3311
Marjanović Đ, Zdravković N, Pavlović M, Nešić K, Savić Radovanović R, Trailović S. Antiparsitic effect of some active components of essential oils. in 19th International Conference Life Sciences for Sustainable Development, Cluj-Napoca, Romania, 24th - 25th September 2020. 2020;:287-287. https://hdl.handle.net/21.15107/rcub_veterinar_3311 .
Marjanović, Đorđe, Zdravković, Nemanja, Pavlović, Marija, Nešić, Ksenija, Savić Radovanović, Radoslava, Trailović, Saša, "Antiparsitic effect of some active components of essential oils" in 19th International Conference Life Sciences for Sustainable Development, Cluj-Napoca, Romania, 24th - 25th September 2020 (2020):287-287, https://hdl.handle.net/21.15107/rcub_veterinar_3311 .