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dc.creatorMarjanović, Đorđe S.
dc.creatorRajković, Milan
dc.creatorNeveu, Cédric
dc.creatorTrailović, Saša
dc.creatorCharvet, Claude
dc.date.accessioned2023-12-14T11:19:12Z
dc.date.available2023-12-14T11:19:12Z
dc.date.issued2021
dc.identifier.urihttps://vet-erinar.vet.bg.ac.rs/handle/123456789/3417
dc.description.abstractParascaris sp. is the only ascarid parasitic nematode in equids and one of the most threatening infectious organisms in horses. Only a limited number of compounds are available for treatment of horse helminthiasis and Parascaris sp. worms have developed resistance to the three major anthelmintic families. In order to overcome the appearance of resistance, there is an urgent need for new therapeutic strategies. The active ingredients of herbal essential oils are potentially effective antiparasitic drugs. Carvacrol is one of the principal chemical of essential oil from Origanum, Thymus, Coridothymus, Thymbra, Satureja and Lippia herbs. However the antiparasitic mode of action of carvacrol is poorly understood so far. Here, the objective of the work was to characterize and investigate the activity of carvacrol on Parascaris sp. nicotinic acetylcholine receptors (AChRs) function both in vivo with the use of worm neuro-muscular flap preparations and in vitro with elecrophysiology on nAChRs expressed in Xenopus oocytes. Strikingly, we observed that carvacrol fully abolished Parascaris sp. muscle contractions elicited by acetylcholine. Conversely, carvacrol inhibited acetylcholine-induced currents on both the nicotine-sentitive AChR and the morantel-sensitive AChR subtypes. Thus, we show for the first time that the body muscle flap preparation is a tractable approach to investigate the pharmacology of Parascaris sp. neuro-muscular system. Our results suggest an intriguing mode of action for carvacrol being a potent antagonist of muscle nAChRs of Parascaris sp. worms which may account for its antiparasitic potency.sr
dc.language.isoensr
dc.relationProjekat Bilateralne saradnje sa Republikom Francuskom za period 2018-2020, projekat broj: 451-03-01963/2017-09/02 ,,Funkcionalna ispitivanja rezistencije na makrociklične laktone u parazita Ascaris suum“ ,sr
dc.rightsopenAccesssr
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.source28-th International Conference of the World Association for the Advancement of Veterinary Parasitology (WAAVP 2021), Dublin, 2021sr
dc.titleAntagonistic effect of carvacrol on nicotinic acetylcholine receptors from the horse parasite Parascaris sp.sr
dc.typeconferenceObjectsr
dc.rights.licenseBYsr
dc.description.otherOral presentation onlinesr
dc.identifier.fulltexthttp://veterinar.vet.bg.ac.rs/bitstream/id/10232/bitstream_10232.pdf
dc.identifier.rcubhttps://hdl.handle.net/21.15107/rcub_veterinar_3417
dc.type.versionpublishedVersionsr


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