Evaluation of genotoxic effects of Apitol (R) (cymiazole hydrochloride) in vitro by measurement of sister chromatid exchange
Abstract
Apitol((R)), with cymiazole hydrochloride as the active ingredient. is used in bee-keeping, against the ectoparasitic mite Varroa destructor. The preparation was evaluated for genotoxicity in cultured human peripheral blood lymphocytes, Sister chromatid exchange, the mitotic index and the cell proliferation index were determined for three experimental concentrations of Apitol((R)), (0.001, 0.01 and 0.1 mg/ml). All concentrations significantly (p < 0.001) increased the mitotic index (MI = 7.35 +/- 0,18% 831 +/- 0.20% and 12.33 +/- 0.25%, respectively), the proliferative index (PI = 1.83 +/- 0.01, 1.84 +/- 0.01 and 1.88 +/- 0.02. respectively) and the frequency of sister chromatid exchange (SCE = 8.19 +/- 1.81, 8.78 +/- 1.80 and 13 46 +/- 1.88, respectively), suggesting that cymiazole hydrochloride has genotoxic potential.
Keywords:
Apitol (R)(cymiazole hydrochloride) / acaricide / honey / Varroa destructor / genotoxic / sister chromatid exchangeSource:
Mutation Research-Genetic Toxicology and Environmental Mutagenesis, 2005, 588, 2, 152-157Publisher:
- Elsevier Science Bv, Amsterdam
Funding / projects:
DOI: 10.1016/j.mrgentox.2005.10.003
ISSN: 1383-5718
PubMed: 16309949
WoS: 000234639400009
Scopus: 2-s2.0-28944449930
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Institution/Community
Fakultet veterinarske medicineTY - JOUR AU - Stanimirović, Zoran AU - Stevanović, Jevrosima AU - Jovanović, S AU - Anđelković, M PY - 2005 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/341 AB - Apitol((R)), with cymiazole hydrochloride as the active ingredient. is used in bee-keeping, against the ectoparasitic mite Varroa destructor. The preparation was evaluated for genotoxicity in cultured human peripheral blood lymphocytes, Sister chromatid exchange, the mitotic index and the cell proliferation index were determined for three experimental concentrations of Apitol((R)), (0.001, 0.01 and 0.1 mg/ml). All concentrations significantly (p < 0.001) increased the mitotic index (MI = 7.35 +/- 0,18% 831 +/- 0.20% and 12.33 +/- 0.25%, respectively), the proliferative index (PI = 1.83 +/- 0.01, 1.84 +/- 0.01 and 1.88 +/- 0.02. respectively) and the frequency of sister chromatid exchange (SCE = 8.19 +/- 1.81, 8.78 +/- 1.80 and 13 46 +/- 1.88, respectively), suggesting that cymiazole hydrochloride has genotoxic potential. PB - Elsevier Science Bv, Amsterdam T2 - Mutation Research-Genetic Toxicology and Environmental Mutagenesis T1 - Evaluation of genotoxic effects of Apitol (R) (cymiazole hydrochloride) in vitro by measurement of sister chromatid exchange VL - 588 IS - 2 SP - 152 EP - 157 DO - 10.1016/j.mrgentox.2005.10.003 ER -
@article{ author = "Stanimirović, Zoran and Stevanović, Jevrosima and Jovanović, S and Anđelković, M", year = "2005", abstract = "Apitol((R)), with cymiazole hydrochloride as the active ingredient. is used in bee-keeping, against the ectoparasitic mite Varroa destructor. The preparation was evaluated for genotoxicity in cultured human peripheral blood lymphocytes, Sister chromatid exchange, the mitotic index and the cell proliferation index were determined for three experimental concentrations of Apitol((R)), (0.001, 0.01 and 0.1 mg/ml). All concentrations significantly (p < 0.001) increased the mitotic index (MI = 7.35 +/- 0,18% 831 +/- 0.20% and 12.33 +/- 0.25%, respectively), the proliferative index (PI = 1.83 +/- 0.01, 1.84 +/- 0.01 and 1.88 +/- 0.02. respectively) and the frequency of sister chromatid exchange (SCE = 8.19 +/- 1.81, 8.78 +/- 1.80 and 13 46 +/- 1.88, respectively), suggesting that cymiazole hydrochloride has genotoxic potential.", publisher = "Elsevier Science Bv, Amsterdam", journal = "Mutation Research-Genetic Toxicology and Environmental Mutagenesis", title = "Evaluation of genotoxic effects of Apitol (R) (cymiazole hydrochloride) in vitro by measurement of sister chromatid exchange", volume = "588", number = "2", pages = "152-157", doi = "10.1016/j.mrgentox.2005.10.003" }
Stanimirović, Z., Stevanović, J., Jovanović, S.,& Anđelković, M.. (2005). Evaluation of genotoxic effects of Apitol (R) (cymiazole hydrochloride) in vitro by measurement of sister chromatid exchange. in Mutation Research-Genetic Toxicology and Environmental Mutagenesis Elsevier Science Bv, Amsterdam., 588(2), 152-157. https://doi.org/10.1016/j.mrgentox.2005.10.003
Stanimirović Z, Stevanović J, Jovanović S, Anđelković M. Evaluation of genotoxic effects of Apitol (R) (cymiazole hydrochloride) in vitro by measurement of sister chromatid exchange. in Mutation Research-Genetic Toxicology and Environmental Mutagenesis. 2005;588(2):152-157. doi:10.1016/j.mrgentox.2005.10.003 .
Stanimirović, Zoran, Stevanović, Jevrosima, Jovanović, S, Anđelković, M, "Evaluation of genotoxic effects of Apitol (R) (cymiazole hydrochloride) in vitro by measurement of sister chromatid exchange" in Mutation Research-Genetic Toxicology and Environmental Mutagenesis, 588, no. 2 (2005):152-157, https://doi.org/10.1016/j.mrgentox.2005.10.003 . .