Pioneering gut health improvements in piglets with phytogenic feed additives
Authors
Yu, Sung JoonMorris, Andrew
Kayal, Advait
Milošević, Ivan
Hao Van, Thi Thu
Bajagai, Yadav Sharma
Stanley, Dragana
Article (Published version)
Metadata
Show full item recordAbstract
This research investigates the effects of phytogenic feed additives (PFAs) on the growth performance, gut microbial community,
and microbial metabolic functions in weaned piglets via a combined 16S rRNA gene amplicon and shotgun metagenomics
approach. A controlled trial was conducted using 200 pigs to highlight the significant influence of PFAs on gut microbiota
dynamics. Notably, the treatment group revealed an increased gut microbiota diversity, as measured with the Shannon and
Simpson indices. The increase in diversity is accompanied by an increase in beneficial bacterial taxa, such as Roseburia,
Faecalibacterium, and Prevotella, and a decline in potential pathogens like Clostridium sensu stricto 1 and Campylobacter.
Shotgun sequencing at the species level confirmed these findings. This modification in microbial profile was coupled with
an altered profile of microbial metabolic pathways, suggesting a reconfiguration of microbial function under PFA influence.
Significant shif...ts in overall microbial community structure by week 8 demonstrate PFA treatment’s temporal impact.
Histomorphological examination unveiled improved gut structure in PFA-treated piglets. The results of this study indicate
that the use of PFAs as dietary supplements can be an effective strategy, augmenting gut microbiota diversity, reshaping
microbial function, enhancing gut structure, and optimising intestinal health of weaned piglets providing valuable implications
for swine production.
Key points
• PFAs significantly diversify the gut microbiota in weaned piglets, aiding balance.
• Changes in gut structure due to PFAs indicate improved resistance to weaning stress.
• PFAs show potential to ease weaning stress, offering a substitute for antibiotics in piglet diets.
Keywords:
Phytogenic feed additives / Gut microbiota / Intestinal morphology / Metagenomics / Metabolic pathways / Antibiotic alternativesSource:
Applied Microbiology and Biotechnology, 2024, 108, 142-Publisher:
- Springer
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Institution/Community
Fakultet veterinarske medicineTY - JOUR AU - Yu, Sung Joon AU - Morris, Andrew AU - Kayal, Advait AU - Milošević, Ivan AU - Hao Van, Thi Thu AU - Bajagai, Yadav Sharma AU - Stanley, Dragana PY - 2024 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/3596 AB - This research investigates the effects of phytogenic feed additives (PFAs) on the growth performance, gut microbial community, and microbial metabolic functions in weaned piglets via a combined 16S rRNA gene amplicon and shotgun metagenomics approach. A controlled trial was conducted using 200 pigs to highlight the significant influence of PFAs on gut microbiota dynamics. Notably, the treatment group revealed an increased gut microbiota diversity, as measured with the Shannon and Simpson indices. The increase in diversity is accompanied by an increase in beneficial bacterial taxa, such as Roseburia, Faecalibacterium, and Prevotella, and a decline in potential pathogens like Clostridium sensu stricto 1 and Campylobacter. Shotgun sequencing at the species level confirmed these findings. This modification in microbial profile was coupled with an altered profile of microbial metabolic pathways, suggesting a reconfiguration of microbial function under PFA influence. Significant shifts in overall microbial community structure by week 8 demonstrate PFA treatment’s temporal impact. Histomorphological examination unveiled improved gut structure in PFA-treated piglets. The results of this study indicate that the use of PFAs as dietary supplements can be an effective strategy, augmenting gut microbiota diversity, reshaping microbial function, enhancing gut structure, and optimising intestinal health of weaned piglets providing valuable implications for swine production. Key points • PFAs significantly diversify the gut microbiota in weaned piglets, aiding balance. • Changes in gut structure due to PFAs indicate improved resistance to weaning stress. • PFAs show potential to ease weaning stress, offering a substitute for antibiotics in piglet diets. PB - Springer T2 - Applied Microbiology and Biotechnology T1 - Pioneering gut health improvements in piglets with phytogenic feed additives VL - 108 SP - 142 DO - 10.1007/s00253-023-12925-2 ER -
@article{ author = "Yu, Sung Joon and Morris, Andrew and Kayal, Advait and Milošević, Ivan and Hao Van, Thi Thu and Bajagai, Yadav Sharma and Stanley, Dragana", year = "2024", abstract = "This research investigates the effects of phytogenic feed additives (PFAs) on the growth performance, gut microbial community, and microbial metabolic functions in weaned piglets via a combined 16S rRNA gene amplicon and shotgun metagenomics approach. A controlled trial was conducted using 200 pigs to highlight the significant influence of PFAs on gut microbiota dynamics. Notably, the treatment group revealed an increased gut microbiota diversity, as measured with the Shannon and Simpson indices. The increase in diversity is accompanied by an increase in beneficial bacterial taxa, such as Roseburia, Faecalibacterium, and Prevotella, and a decline in potential pathogens like Clostridium sensu stricto 1 and Campylobacter. Shotgun sequencing at the species level confirmed these findings. This modification in microbial profile was coupled with an altered profile of microbial metabolic pathways, suggesting a reconfiguration of microbial function under PFA influence. Significant shifts in overall microbial community structure by week 8 demonstrate PFA treatment’s temporal impact. Histomorphological examination unveiled improved gut structure in PFA-treated piglets. The results of this study indicate that the use of PFAs as dietary supplements can be an effective strategy, augmenting gut microbiota diversity, reshaping microbial function, enhancing gut structure, and optimising intestinal health of weaned piglets providing valuable implications for swine production. Key points • PFAs significantly diversify the gut microbiota in weaned piglets, aiding balance. • Changes in gut structure due to PFAs indicate improved resistance to weaning stress. • PFAs show potential to ease weaning stress, offering a substitute for antibiotics in piglet diets.", publisher = "Springer", journal = "Applied Microbiology and Biotechnology", title = "Pioneering gut health improvements in piglets with phytogenic feed additives", volume = "108", pages = "142", doi = "10.1007/s00253-023-12925-2" }
Yu, S. J., Morris, A., Kayal, A., Milošević, I., Hao Van, T. T., Bajagai, Y. S.,& Stanley, D.. (2024). Pioneering gut health improvements in piglets with phytogenic feed additives. in Applied Microbiology and Biotechnology Springer., 108, 142. https://doi.org/10.1007/s00253-023-12925-2
Yu SJ, Morris A, Kayal A, Milošević I, Hao Van TT, Bajagai YS, Stanley D. Pioneering gut health improvements in piglets with phytogenic feed additives. in Applied Microbiology and Biotechnology. 2024;108:142. doi:10.1007/s00253-023-12925-2 .
Yu, Sung Joon, Morris, Andrew, Kayal, Advait, Milošević, Ivan, Hao Van, Thi Thu, Bajagai, Yadav Sharma, Stanley, Dragana, "Pioneering gut health improvements in piglets with phytogenic feed additives" in Applied Microbiology and Biotechnology, 108 (2024):142, https://doi.org/10.1007/s00253-023-12925-2 . .