Neuroendocrine aspect of heart failure in dogs, cats and horses

Abstract

Heart failure is a clinical syndrome caused by a heart disease that results in systolic and/or dyastolic cardiac dysfunction severe enough to overwhelm the cardiovascular system's compensatory mechanisms. Compensation for cardiac failure include activation of the sympathetic nervous system, renin-angiotensin-aldosteron system, vasopressin, natriuretic peptides, endothelins. There is a real possibility that measurement of plasma concentrations of natriuretic peptides will prove useful in the diagnosis and clinical assessment of patients in veterinary cardiology.

Srčana insuficijencija predstavlja klinički sindrom prouzrokovan srčanim oboljenjem, koji dovodi do sistolne i/ili dijastolne srčane disfunkcije, koja prevazilazi efekte kompenzatornih mehanizama kardiovaskularnog sistema. Kompenzatorni mehanizmi se ostvaruju preko dominacije simpatikusa, renin-angio-tenzin-aldosteron sistema, vazopresina, natrijumuretskih hormona, endotelina. U veterinarskoj kardiologiji pasa, mačaka i konja postoji opravdano interesovanje za natrijumuretične peptide kao biomarkere srčane insuficijencije.