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Ispitivanje genotoksičnog potencijala levamizol hidrohlorida na ćelijama kostne srži pacova Wistar soja

dc.creatorKulić, Milan
dc.creatorStanimirović, Zoran
dc.creatorMarković, Biljana
dc.creatorRistić, Siniša
dc.date.accessioned2020-06-03T12:59:09Z
dc.date.available2020-06-03T12:59:09Z
dc.date.issued2006
dc.identifier.issn0350-2457
dc.identifier.urihttps://vet-erinar.vet.bg.ac.rs/handle/123456789/396
dc.description.abstractAn experiment was performed under in vivo conditions on bone marrow cells of Wistar rats. The following doses of levamisole hydrochloride were tested: a therapeutic dose of 2.2 mg/kg bm, a dose of 4.4 mg/kg bm, LD50 -25% mg/kg bm, and LD50 -75% mg/kg bm. We followed the effect of levamisole hydrochloride on kinetics of the cell cycle and the appearance of structural and numeric changes in chromosomes in bone marrow cells. The therapeutic dose of levamisole of 2.2 mg/kg bm exhibited a capability to increase mitotic activity in the observed cells, thus confirming knowledge of the immunostimulative effect of this dose of the medicine under in vivo conditions. The other tested doses of levamisole in this experiment, observed in comparison with the control group, had an opposite effect, namely, they caused a reduction in the mitotic activity of bone marrow cells. All the examined doses in vivo exhibited the ability to induce numeric (aneuploid and polyploid) and structural (lesions, breaks and insertions) chromosomal aberrations. It can be concluded on the grounds of these findings that the examined doses have a genotoxic effect.en
dc.description.abstractEksperiment je izveden u in vivo uslovima na ćelijama kostne srži pacova Wistar soja. Testirane su doze levamizol hidrohlorida i to: terapijska doza od 2.2 mg/kg, t.m., zatim doza od 4,4 mg/kg t.m., LD50 do 25% mg/kg t.m. i LD50 -75% mg/kg t.m.. Praćen je uticaj levamizol hidrohlorida na kinetiku ćelijskog ciklusa i pojavljivanje strukturnih i numeričkih promena na hromozomima u ćelijama kostne srži. Terapijska doza levamizola od 2,2 mg/kg t.m. pokazala je sposobnost povećanja mitotske aktivnosti posmatranih ćelija, tako potkrepljujući saznanja o imunostimulativnom efektu ove doze leka u in vivo uslovima. Ostale testirane doze levamizola u ovom eksperimentu, posmatrano u odnosu na kontrolnu grupu, imale su suprotan efekat, tj. uslovile su smanjenje mitotske aktivnosti ćelija kostne srži. Sve ispitivane doze in vivo pokazuju sposobnost indukcije numeričkih (aneuploidija i polipleidija) i strukturnih (lezije, prekidi i insercije) aberacija hromozoma. Na osnovu toga može da se zaključi da ispitivane doze imaju genotoksični efekat.sr
dc.publisherUniverzitet u Beogradu - Fakultet veterinarske medicine, Beograd
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceVeterinarski Glasnik
dc.subjectgenotoxityen
dc.subjectcytotoxicityen
dc.subjectaneuploiden
dc.subjectpolyploid lesionsen
dc.subjectbreaksen
dc.subjectinsertionsen
dc.subjectgenotoksičnostsr
dc.subjectcitotoksičnostsr
dc.subjectaneuploidijesr
dc.subjectpoliploidijelezijesr
dc.subjectprekidisr
dc.subjectinsercijesr
dc.titleInvestigations of genotoxic potential of levamisole hydrochloride in bone marrow cells of Wistar ratsen
dc.titleIspitivanje genotoksičnog potencijala levamizol hidrohlorida na ćelijama kostne srži pacova Wistar sojasr
dc.typearticle
dc.rights.licenseBY
dcterms.abstractМарковић, Биљана; Ристић, Синиша; Кулић, Милан; Станимировић, Зоран;
dc.citation.volume60
dc.citation.issue1-2
dc.citation.spage3
dc.citation.epage9
dc.citation.other60(1-2): 3-9
dc.identifier.doi10.2298/VETGL0602003K
dc.identifier.fulltexthttps://vet-erinar.vet.bg.ac.rs/bitstream/id/961/395.pdf
dc.type.versionpublishedVersion


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