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dc.creatorKnežević, Milijana
dc.creatorAleksić-Kovačević, Sanja
dc.creatorAleksić, Zoran
dc.date.accessioned2020-06-03T13:02:23Z
dc.date.available2020-06-03T13:02:23Z
dc.date.issued2007
dc.identifier.issn0074-7696
dc.identifier.urihttp://vet-erinar.vet.bg.ac.rs/handle/123456789/442
dc.description.abstractEsophagogastric ulcer is an independent disease in swine that is characterized by ulcerous autodigestion of the cutaneous mucosa, which does not exhibit a tendency to recover, but, on the contrary, a tendency toward severe hemorrhaging, with a predominantly lethal outcome. Since it develops in the part of the stomach that is morphologically and functionally different from other glandular mucosa, it was questioned earlier whether it could be a peptic ulcer based on its nature. Spontaneous ulcers, usually of the stomach, commonly occur in many domestic animals. Some of these lesions are chronic and they may occur in either the glandular or squamous-lined regions of the stomach. As with the human disease, the pathogenesis in domestic animals is multifactorial, poorly understood, and variable between and within species. Environmental stress and dietary factors are very important in the ulcer disease in swine. It has been shown that the Helicobacter spp. is strongly associated with naturally occurring ulcer and preulcer lesions of the pars esophagea in swine, which raises the possibility that Helicobacter spp. is an important factor in the pathogenesis of these lesions. The dynamics of the development of esophagogastric ulcers imply hyperplastic lesions (parakeratosis and hyperkeratosis), keratolysis, erosions, peptic necrosis, and the development of ulcers with all the characteristics of peptic ulcerations in other localities. In addition, K6 is expressed in association with the mucosal changes. The pattern of the intermediate filaments of keratin suggests that epithelial proliferation, which leads to visible hyperkeratosis, constitutes the essence of gastric ulcers in swine.en
dc.publisherElsevier Academic Press Inc, San Diego
dc.rightsrestrictedAccess
dc.sourceInternational Review of Cytology - A Survey of Cell Biology, Vol 260
dc.subjectswineen
dc.subjectesophagogastric ulceren
dc.subjectparakeratosisen
dc.subjecthyperkeratosisen
dc.subjectkeratinen
dc.titleCell proliferation in pathogenesis of esophagogastric lesions in pigsen
dc.typebookPart
dc.rights.licenseARR
dcterms.abstractКнежевић, Милијана; Aлексић, Зоран; Aлексић-Ковачевић, Сања;
dc.citation.volume260
dc.citation.spage1
dc.citation.epage34
dc.citation.other260: 1-34
dc.citation.rankM21
dc.identifier.wos000246617000001
dc.identifier.doi10.1016/S0074-7696(06)60001-6
dc.identifier.pmid17482903
dc.identifier.scopus2-s2.0-34247625104
dc.identifier.rcubconv_1545
dc.type.versionpublishedVersion


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