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dc.creatorMarinković, Darko
dc.creatorAleksić-Kovačević, Sanja
dc.creatorPlamenac, Pavle
dc.date.accessioned2020-06-03T13:02:30Z
dc.date.available2020-06-03T13:02:30Z
dc.date.issued2007
dc.identifier.issn0074-7696
dc.identifier.urihttp://vet-erinar.vet.bg.ac.rs/handle/123456789/444
dc.description.abstractChronic obstructive pulmonary disease (COPD) is an inflammatory obstructive disease of the airways characterized with hypersensitivity of the airway tissues to various allergens, most commonly the fungi contained in the poor-quality hay and straw bedding-Saccharopolyspora rectivirgula, Aspergillus fumigatus, and Thermoactinomyces vulgaris. It is manifested clinically in middle-aged horses with recurrent episodes of dyspnea, chronic cough, and their reduced athletic and working capacity. Pulmonary emphysema and lack of pulmonary collapse are the most common gross lesion. Pathohistological findings in horses with COPD are chronic bronchitis/bronchiolitis, with characteristic changes in lumen, mucosa, submucosa, and smooth muscle layer and alveolar emphysema, both distensive and destructive form. Increased immunoreactivity in lungs and tracheobronchial lymph nodes is also noted. Most common lesions seen on cytology imprint smears from tracheal bifurcation is thick, viscous, PAS-positive mucus that forms Curschmanns spirals. Dominant cell population consists of desquamated airway epithelial cells, as well as eosinophils, neutrophils, mast cells, erythrocytes, and alveolar macrophages. Primary pulmonary pathogens as well as potential contaminants and secondary infection agents were isolated bacteriologically from lung samples. All of the aforementioned findings correlate pointing to the fact that chronic bronchitis/bronchiolitis represents a basic substrate of COPD, which have combined inflammatory and immunological etiology, and emphysema is secondary to airway obstruction.en
dc.publisherElsevier Academic Press Inc, San Diego
dc.rightsrestrictedAccess
dc.sourceInternational Review of Cytology - A Survey of Cell Biology, Vol 257
dc.subjecthorseen
dc.subjectlungsen
dc.subjectCOPDen
dc.subjectpathohistologyen
dc.subjectcytologyen
dc.titleCellular basis of chronic obstructive pulmonary disease in horsesen
dc.typebookPart
dc.rights.licenseARR
dcterms.abstractПламенац, Павле; Aлексић-Ковачевић, Сања; Маринковић, Дарко;
dc.citation.volume257
dc.citation.spage213
dc.citation.epage247
dc.citation.other257: 213-247
dc.citation.rankM21
dc.identifier.wos000244749500006
dc.identifier.doi10.1016/S0074-7696(07)57006-3
dc.identifier.pmid17280899
dc.identifier.scopus2-s2.0-33846661963
dc.identifier.rcubconv_1535
dc.type.versionpublishedVersion


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