We examined dose-dependent relationship between toluene and total CYP450 content, CYP2E1, CYP2B6 contents and GST from rat liver microsomes. Wistar rats were treated i.p. with toluene in propylene glycol daily for 12 days, at doses of 0.38 mM/kg bw (I group, female), and daily for 6 days at doses of 5 mM/kg bw (11 group, female, III group, male) and control group (IV group, female). Toluene exposure resulted in significant increase in the total CYP450 content and level of liver microsomal CYP2E1 and decrease in the level of CYP2136 in all exposed groups. Microsomal GST activity was enhanced by toluene in all groups. These results, which are sex-related, suggest that toluene influence total CYP450 content, levels of CYP2E1 and CYP2136 isoforms.
Source:
Proceedings of The 15th International Conference on Cytochromes P450 - Biochemistry, Biophysics and, 2007, 53-
Publisher:
Medimond S R L, 40128 Bologna
Funding / projects:
Ministry of Science, Technology and Development of the Republic of Serbia [1518]
TY - CONF
AU - Stajković, Silvana
AU - Borozan, Sunčica
AU - Gađanski-Omerović, Gordana
AU - Magić, Z.
PY - 2007
UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/456
AB - We examined dose-dependent relationship between toluene and total CYP450 content, CYP2E1, CYP2B6 contents and GST from rat liver microsomes. Wistar rats were treated i.p. with toluene in propylene glycol daily for 12 days, at doses of 0.38 mM/kg bw (I group, female), and daily for 6 days at doses of 5 mM/kg bw (11 group, female, III group, male) and control group (IV group, female). Toluene exposure resulted in significant increase in the total CYP450 content and level of liver microsomal CYP2E1 and decrease in the level of CYP2136 in all exposed groups. Microsomal GST activity was enhanced by toluene in all groups. These results, which are sex-related, suggest that toluene influence total CYP450 content, levels of CYP2E1 and CYP2136 isoforms.
PB - Medimond S R L, 40128 Bologna
C3 - Proceedings of The 15th International Conference on Cytochromes P450 - Biochemistry, Biophysics and
T1 - The effects of toluene on the total CYP450 content and on levels of CYP2E1 and 2B6 Isoforms in the rat liver
SP - 53
UR - https://hdl.handle.net/21.15107/rcub_veterinar_456
ER -
@conference{
author = "Stajković, Silvana and Borozan, Sunčica and Gađanski-Omerović, Gordana and Magić, Z.",
year = "2007",
abstract = "We examined dose-dependent relationship between toluene and total CYP450 content, CYP2E1, CYP2B6 contents and GST from rat liver microsomes. Wistar rats were treated i.p. with toluene in propylene glycol daily for 12 days, at doses of 0.38 mM/kg bw (I group, female), and daily for 6 days at doses of 5 mM/kg bw (11 group, female, III group, male) and control group (IV group, female). Toluene exposure resulted in significant increase in the total CYP450 content and level of liver microsomal CYP2E1 and decrease in the level of CYP2136 in all exposed groups. Microsomal GST activity was enhanced by toluene in all groups. These results, which are sex-related, suggest that toluene influence total CYP450 content, levels of CYP2E1 and CYP2136 isoforms.",
publisher = "Medimond S R L, 40128 Bologna",
journal = "Proceedings of The 15th International Conference on Cytochromes P450 - Biochemistry, Biophysics and",
title = "The effects of toluene on the total CYP450 content and on levels of CYP2E1 and 2B6 Isoforms in the rat liver",
pages = "53",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_456"
}
Stajković, S., Borozan, S., Gađanski-Omerović, G.,& Magić, Z.. (2007). The effects of toluene on the total CYP450 content and on levels of CYP2E1 and 2B6 Isoforms in the rat liver. in Proceedings of The 15th International Conference on Cytochromes P450 - Biochemistry, Biophysics and
Medimond S R L, 40128 Bologna., 53.
https://hdl.handle.net/21.15107/rcub_veterinar_456
Stajković S, Borozan S, Gađanski-Omerović G, Magić Z. The effects of toluene on the total CYP450 content and on levels of CYP2E1 and 2B6 Isoforms in the rat liver. in Proceedings of The 15th International Conference on Cytochromes P450 - Biochemistry, Biophysics and. 2007;:53.
https://hdl.handle.net/21.15107/rcub_veterinar_456 .
Stajković, Silvana, Borozan, Sunčica, Gađanski-Omerović, Gordana, Magić, Z., "The effects of toluene on the total CYP450 content and on levels of CYP2E1 and 2B6 Isoforms in the rat liver" in Proceedings of The 15th International Conference on Cytochromes P450 - Biochemistry, Biophysics and (2007):53,
https://hdl.handle.net/21.15107/rcub_veterinar_456 .
