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dc.creatorStajković, Silvana
dc.creatorBorozan, Sunčica
dc.creatorGađanski-Omerović, Gordana
dc.creatorMagić, Z.
dc.date.accessioned2020-06-03T13:03:23Z
dc.date.available2020-06-03T13:03:23Z
dc.date.issued2007
dc.identifier.urihttps://vet-erinar.vet.bg.ac.rs/handle/123456789/456
dc.description.abstractWe examined dose-dependent relationship between toluene and total CYP450 content, CYP2E1, CYP2B6 contents and GST from rat liver microsomes. Wistar rats were treated i.p. with toluene in propylene glycol daily for 12 days, at doses of 0.38 mM/kg bw (I group, female), and daily for 6 days at doses of 5 mM/kg bw (11 group, female, III group, male) and control group (IV group, female). Toluene exposure resulted in significant increase in the total CYP450 content and level of liver microsomal CYP2E1 and decrease in the level of CYP2136 in all exposed groups. Microsomal GST activity was enhanced by toluene in all groups. These results, which are sex-related, suggest that toluene influence total CYP450 content, levels of CYP2E1 and CYP2136 isoforms.en
dc.publisherMedimond S R L, 40128 Bologna
dc.relationMinistry of Science, Technology and Development of the Republic of Serbia [1518]
dc.rightsrestrictedAccess
dc.sourceProceedings of The 15th International Conference on Cytochromes P450 - Biochemistry, Biophysics and
dc.titleThe effects of toluene on the total CYP450 content and on levels of CYP2E1 and 2B6 Isoforms in the rat liveren
dc.typeconferenceObject
dc.rights.licenseARR
dcterms.abstractБорозан, Сунчица; Стајковић, Силвана; Гађански-Омеровић, Гордана; Магић, З.;
dc.citation.spage53
dc.citation.other: 53-
dc.identifier.wos000251734400008
dc.identifier.rcubhttps://hdl.handle.net/21.15107/rcub_veterinar_456
dc.type.versionpublishedVersion


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