Show simple item record

Morfološka i imunohistohemijska ispitivanja hirurški odstranjenih tumora mlečne žlezde kuja

dc.creatorMagaš, Vladimir
dc.creatorJović, Slavoljub
dc.creatorNešić, Vladimir
dc.creatorBacetić, D.
dc.creatorAleksić-Kovačević, Sanja
dc.date.accessioned2020-06-03T13:04:50Z
dc.date.available2020-06-03T13:04:50Z
dc.date.issued2007
dc.identifier.issn0567-8315
dc.identifier.urihttp://vet-erinar.vet.bg.ac.rs/handle/123456789/477
dc.description.abstractIn this study an estimation of the malignancy of mammary gland tumors was carried out based upon clinical examination, macroscopic and pathohistological characteristics of neoplasms and expression of cytokeratins. In the study 60 bitches of different ages, race and reproductive status with clinically evident signs of mammary gland tumor were included. After clinical examination the mammary gland tumors were excided, after which tissue samples were taken for subsequent pathohistological and immunohistochemical analysis. Tumors are classified according to the latest WHO recommendation (1999). The ratio of malignant tumors vs. non-malignant was 1.9 : 1. The most frequent malignant tumor was adenocarcinoma (n=17), followed by complex adenocarcinoma (n=12), carcinoma in mixed tumors (n=5), mucinous carcinoma (n=3), and fibrosarcoma and osteosarcoma, one of each. Most common benign changes were benign mixed tumors (n=10) and adenoma (n=6). Hyperplasia of the mammary gland was found in two bitches, while chronic steatitis, fibrosis and complex adenoma were reported only in individual cases. The expression of cytokeratins on different malignant and benign neoplastic cells was determined by the immunohystochemical peroxidase-antiperoxidase method. In simple carcinoma a positive reaction was established within the epithelium of the lumen of the alveoli and in the stromal tumor cells present in the lymph and blood vessels. In the cells of complex tumors cytokeratin was expressed on epithelial cells as well as on spindle, stellate and myoepithelial cells.en
dc.description.abstractU radu je izvršena procena maligniteta tumora mlečne žlezde kuja na osnovu kliničkog pregleda, makroskopskih i patohistoloških karateristika neoplazmi i ekspresije citokeratina. Ispitivanjem je bilo obuhvaćeno 60 kuja različite starosti, rase i reproduktivnog statusa, sa klinički uočljivim promenama na mlečnoj žlezdi. Posle kliničke opservacije, kod svih ispitivanih kuja izvršeno je hirurško odstranjivanje tumorskih proliferata, nakon čega su uzimani tkivni uzorci za patohistološku i imunohistohemijsku analizu. Tumori su klasifikovani prema najnovijoj preporuci WHO iz 1999. godine. Odnos malignih i benignih tumora je iznosio 1,9:1 u korist malignih alteracija. Najzastupljeniji maligni tumori su prosti adenokarcinomi (17 kuja), zatim kompleksni adenokarcinomi (12 kuja), iza kojih sledi 5 karcinoma u mešovitom tumoru, 3 mucinozna karcinoma i po jedan fibrosarkom i osteosarkom. Od benignih promena najzastupljeniji su benigni mešoviti tumori (10 kuja) i adenomi (6 kuja). Hiperplazija mlečne žlezde nađena je kod dve kuje, dok su hronični steatis, fibroza i kompleksni adenom dijagnostikovani u pojedinačnim slučajevima. Imunohistohemijskom metodom peroksidaza-antiperoksidaza, ustanovljena je ekspresija citokeratina na različitim ćelijama benignihimalignih neoplazmi. U prostim karcinomima, pozitivna reakcija nađena je u epitelu lumena kanalića i alveola, kao i na tumorskim ćelijama u stromi tumora, u limfnimikrvnim sudovima. U kompleksnim karcinomima, citokeratin je eksprimiran osim na epitelnim i na mirujućim, vretenastim i zvezdastim mioepitelnim ćelijama.sr
dc.publisherUniverzitet u Beogradu - Fakultet veterinarske medicine, Beograd
dc.rightsopenAccess
dc.sourceActa veterinaria - Beograd
dc.subjectbitchen
dc.subjectmammary gland tumorsen
dc.subjectpathohistologyen
dc.subjectcytokeratinen
dc.titleMorphological and immunohistochemical assays of surgically removed mammary gland tumors in bitchesen
dc.titleMorfološka i imunohistohemijska ispitivanja hirurški odstranjenih tumora mlečne žlezde kujasr
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЈовић, Славољуб; Магаш, Владимир; Бацетић, Д.; Aлексић-Ковачевић, Сања; Нешић, Владимир; Морфолошка и имунохистохемијска испитивања хируршки одстрањених тумора млечне жлезде куја; Морфолошка и имунохистохемијска испитивања хируршки одстрањених тумора млечне жлезде куја;
dc.citation.volume57
dc.citation.issue1
dc.citation.spage37
dc.citation.epage45
dc.citation.other57(1): 37-45
dc.citation.rankM23
dc.identifier.wos000245603000005
dc.identifier.doi10.2298/AVB0701037M
dc.identifier.scopus2-s2.0-34247620705
dc.identifier.fulltexthttp://veterinar.vet.bg.ac.rs/bitstream/id/1038/476.pdf
dc.identifier.rcubconv_653
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record