Show simple item record

dc.creatorBajić, Vladan
dc.creatorSpremo-Potparević, Biljana
dc.creatorŽivković, L.
dc.creatorĐelić, Ninoslav
dc.creatorSmith, Mark A.
dc.date.accessioned2020-06-03T13:06:57Z
dc.date.available2020-06-03T13:06:57Z
dc.date.issued2008
dc.identifier.issn1756-2392
dc.identifier.urihttp://vet-erinar.vet.bg.ac.rs/handle/123456789/507
dc.description.abstractChromosomal involvement is a legitimate, yet not well understood, feature of Alzheimer disease (AD). Firstly, AD affects more women than men. Secondly, the amyloid-β protein precursor genetic mutations, responsible for a cohort of familial AD cases, reside on chromosome 21, the same chromosome responsible for the developmental disorder Down's syndrome. Thirdly, lymphocytes from AD patients display a novel chromosomal phenotype, namely premature centromere separation (PCS). Other documented morphological phenomena associated with AD include the occurrence of micronuclei, aneuploidy, binucleation, telomere instability, and cell cycle re-entry protein expression. Based on these events, here we present a novel hypothesis that the time dimension of cell cycle re-entry in AD is highly regulated by centromere cohesion dynamics. In view of the fact that neurons can re-enter the cell division cycle, our hypothesis predicts that alterations in the signaling pathway leading to premature cell death in neurons is a consequence of altered regulation of the separation of centromeres as a function of time. It is well known that centromeres in the metaphase anaphase transition separate in a non-random, sequential order. This sequence has been shown to be deregulated in aging cells, various tumors, syndromes of chromosome instability, following certain chemical inductions, as well as in AD. Over time, premature chromosome separation is both a result of, and a driving force behind, further cohesion impairment, activation of cyclin dependent kinases, and mitotic catastrophe-a vicious circle resulting in cellular degeneration and death.en
dc.rightsrestrictedAccess
dc.sourceBioscience Hypotheses
dc.subjectAlzheimer diseaseen
dc.subjectAneuploidyen
dc.subjectCell cycleen
dc.subjectChromosomeen
dc.titleIs the time dimension of the cell cycle re-entry in AD regulated by centromere cohesion dynamics?en
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСпремо-Потпаревић, Биљана; Ђелић, Нинослав; Бајић, Владан; Живковић, Л.; Смитх, Марк A.;
dc.citation.volume1
dc.citation.issue3
dc.citation.spage156
dc.citation.epage161
dc.citation.other1(3): 156-161
dc.identifier.doi10.1016/j.bihy.2008.03.006
dc.identifier.scopus2-s2.0-50449095363
dc.identifier.rcubconv_2872
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record