Effects of peroral insulin and glucose on circulating insulin-like growth factor-I, its binding proteins and thyroid hormones in neonatal calves
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2008
Authors
Kirovski, DanijelaLazarević, Miodrag
Baricevic-Jones, Ivona
Nedić, Olgica
Masnikosa, Rornana
Nikolić-Judith, Anna
Article (Published version)
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There is disagreement in the literature about the ability of neonatal calves to absorb perorally administered insulin. This study evaluated the absorption of a bolus of insulin administered alone or with an energy souce and its effects on the circulating insulin-like growth factor system and thyroid hormones in newborn Holstein-Friesian calves. Within 1 h of dosing, mean serum insulin and triiodothyronine (T3) concentrations had increased considerably, whether the insulin was applied alone (n = 4) or together with glucose (n = 4), accompanied by marked hypoglycemia. No significant changes were observed in control calves (n = 4) given the vehicle solution. Increased serum glucose and T3 concentrations with no change in insulinemia occurred in a 4th group of calves given glucose alone. At 32 h of age and after 3 meals of colostrum there were no differences in glycemia, insulinemia, or proteinemia among the 4 groups of calves examined. Mean serum insulin-like growth factor-I (IGF-I) tende...d to decrease over this period in the control group. The decrease was more pronounced in the insulin-treated group but absent in both groups that received glucose. These differences were associated with equivalent differences in abundance of the 40-45K IGF-binding protein-3 (IGFBP-3); however, lower molecular mass IGFBPs were not affected. The results show that a pharmacological peroral dose of insulin can lead to rapid systemic alterations in the IGF/IGFBP system in neonatal calves that can be modified by simultaneous administration of a small energy supply in the form of glucose.
Source:
Canadian Journal of Veterinary Research-Revue Canadienne De Recherche Veterinaire, 2008, 72, 3, 253-258Publisher:
- Canadian Vet Med Assoc, Ottawa
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Fakultet veterinarske medicineTY - JOUR AU - Kirovski, Danijela AU - Lazarević, Miodrag AU - Baricevic-Jones, Ivona AU - Nedić, Olgica AU - Masnikosa, Rornana AU - Nikolić-Judith, Anna PY - 2008 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/534 AB - There is disagreement in the literature about the ability of neonatal calves to absorb perorally administered insulin. This study evaluated the absorption of a bolus of insulin administered alone or with an energy souce and its effects on the circulating insulin-like growth factor system and thyroid hormones in newborn Holstein-Friesian calves. Within 1 h of dosing, mean serum insulin and triiodothyronine (T3) concentrations had increased considerably, whether the insulin was applied alone (n = 4) or together with glucose (n = 4), accompanied by marked hypoglycemia. No significant changes were observed in control calves (n = 4) given the vehicle solution. Increased serum glucose and T3 concentrations with no change in insulinemia occurred in a 4th group of calves given glucose alone. At 32 h of age and after 3 meals of colostrum there were no differences in glycemia, insulinemia, or proteinemia among the 4 groups of calves examined. Mean serum insulin-like growth factor-I (IGF-I) tended to decrease over this period in the control group. The decrease was more pronounced in the insulin-treated group but absent in both groups that received glucose. These differences were associated with equivalent differences in abundance of the 40-45K IGF-binding protein-3 (IGFBP-3); however, lower molecular mass IGFBPs were not affected. The results show that a pharmacological peroral dose of insulin can lead to rapid systemic alterations in the IGF/IGFBP system in neonatal calves that can be modified by simultaneous administration of a small energy supply in the form of glucose. PB - Canadian Vet Med Assoc, Ottawa T2 - Canadian Journal of Veterinary Research-Revue Canadienne De Recherche Veterinaire T1 - Effects of peroral insulin and glucose on circulating insulin-like growth factor-I, its binding proteins and thyroid hormones in neonatal calves VL - 72 IS - 3 SP - 253 EP - 258 UR - https://hdl.handle.net/21.15107/rcub_veterinar_534 ER -
@article{ author = "Kirovski, Danijela and Lazarević, Miodrag and Baricevic-Jones, Ivona and Nedić, Olgica and Masnikosa, Rornana and Nikolić-Judith, Anna", year = "2008", abstract = "There is disagreement in the literature about the ability of neonatal calves to absorb perorally administered insulin. This study evaluated the absorption of a bolus of insulin administered alone or with an energy souce and its effects on the circulating insulin-like growth factor system and thyroid hormones in newborn Holstein-Friesian calves. Within 1 h of dosing, mean serum insulin and triiodothyronine (T3) concentrations had increased considerably, whether the insulin was applied alone (n = 4) or together with glucose (n = 4), accompanied by marked hypoglycemia. No significant changes were observed in control calves (n = 4) given the vehicle solution. Increased serum glucose and T3 concentrations with no change in insulinemia occurred in a 4th group of calves given glucose alone. At 32 h of age and after 3 meals of colostrum there were no differences in glycemia, insulinemia, or proteinemia among the 4 groups of calves examined. Mean serum insulin-like growth factor-I (IGF-I) tended to decrease over this period in the control group. The decrease was more pronounced in the insulin-treated group but absent in both groups that received glucose. These differences were associated with equivalent differences in abundance of the 40-45K IGF-binding protein-3 (IGFBP-3); however, lower molecular mass IGFBPs were not affected. The results show that a pharmacological peroral dose of insulin can lead to rapid systemic alterations in the IGF/IGFBP system in neonatal calves that can be modified by simultaneous administration of a small energy supply in the form of glucose.", publisher = "Canadian Vet Med Assoc, Ottawa", journal = "Canadian Journal of Veterinary Research-Revue Canadienne De Recherche Veterinaire", title = "Effects of peroral insulin and glucose on circulating insulin-like growth factor-I, its binding proteins and thyroid hormones in neonatal calves", volume = "72", number = "3", pages = "253-258", url = "https://hdl.handle.net/21.15107/rcub_veterinar_534" }
Kirovski, D., Lazarević, M., Baricevic-Jones, I., Nedić, O., Masnikosa, R.,& Nikolić-Judith, A.. (2008). Effects of peroral insulin and glucose on circulating insulin-like growth factor-I, its binding proteins and thyroid hormones in neonatal calves. in Canadian Journal of Veterinary Research-Revue Canadienne De Recherche Veterinaire Canadian Vet Med Assoc, Ottawa., 72(3), 253-258. https://hdl.handle.net/21.15107/rcub_veterinar_534
Kirovski D, Lazarević M, Baricevic-Jones I, Nedić O, Masnikosa R, Nikolić-Judith A. Effects of peroral insulin and glucose on circulating insulin-like growth factor-I, its binding proteins and thyroid hormones in neonatal calves. in Canadian Journal of Veterinary Research-Revue Canadienne De Recherche Veterinaire. 2008;72(3):253-258. https://hdl.handle.net/21.15107/rcub_veterinar_534 .
Kirovski, Danijela, Lazarević, Miodrag, Baricevic-Jones, Ivona, Nedić, Olgica, Masnikosa, Rornana, Nikolić-Judith, Anna, "Effects of peroral insulin and glucose on circulating insulin-like growth factor-I, its binding proteins and thyroid hormones in neonatal calves" in Canadian Journal of Veterinary Research-Revue Canadienne De Recherche Veterinaire, 72, no. 3 (2008):253-258, https://hdl.handle.net/21.15107/rcub_veterinar_534 .