Histopathological evaluation of most frequent liver diseases in cats

Abstract

Histological analysis was performed on the liver of 27 cats of different breeds, age and sex, autopsied at the Department of Pathological Morphology of the Faculty of Veterinary Medicine of the University of Belgrade, and findings showed lymphoplasmocytic cholangiohepatitis, different degrees of fibrosis, passive hyperemia, fatty changes, cholestase, and neoplasms. The mentioned entities occurred very rarely as individual morphological manifestations, because the liver has different functions so that one morphological change often causes others to follow. Thus, for example, fibrosis was often followed by intrahepatic cholestase. Histopathological evaluation of liver disease is important not only in the autopsied samples, but also in diagnostics of liver diseases, in samples obtained by biopsy, which is important for making a precise diagnosis. The interpretation of the established histological changes in the liver requires close cooperation between clinicians and pathologists, because the final diagnosis is made on the grounds of morphological, biochemical and clinical findings.

Histološkom analizom jetre kod 27 mačaka različite rase, pola i starosti, obdukovanih na Katedri za patološku morfologiju Fakulteta veterinarske medicine Univerziteta u Beogradu, ustanovljeni su limfoplazmocitni holangiohepatitis, fibroza različitog stepena, pasivna hiperemija, masna promena, holestaza i neoplazme. Navedeni entiteti su se vrlo retko javljali kao pojedinačne morfološke manifestacije, pošto jetra ima različite funkcije, pa jedna morfološka promena često za sobom povlači i druge. Tako je, na primer, fibroza bila često praćena intrahepatič nom holestazom. Histopatološka procena oboljenja jetre ima značaja ne samo na uzorcima sa obdukcije, već i kod dijagnostike oboljenja jetre, na uzorcima dobijenim biopsijom, što je značajno za postavljanje decidne dijagnoze. Za tumačenje ustanovljenih histoloških promena u jetri potrebna je tesna saradnja između kliničara i patologa, jer se konačna dijagnoza postavlja na osnovu morfoloških, biohemijskih i kliničkih nalaza.