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Efekat ekstrakta goveđeg timusa na imunski odgovor ozračenih wistar pacova

dc.creatorJovanović, Milan
dc.creatorLazarević, Miodrag
dc.creatorPopović, N.
dc.creatorVojvodić, Danilo
dc.date.accessioned2020-06-03T13:14:31Z
dc.date.available2020-06-03T13:14:31Z
dc.date.issued2009
dc.identifier.issn0567-8315
dc.identifier.urihttps://vet-erinar.vet.bg.ac.rs/handle/123456789/613
dc.description.abstractImmunomodulation is a phenomenon that is based on the influence of different endogenous and exogenous substances on the function of molecules and cells pertaining to the immune system. Some components extracted from the bovine thymus have immunomodulating features and can, both in animals and humans, by suppressing the immune response (humoral and/or cellular) bring about immunostimulation and increased organism resistance. In this paper the effects of bovine thymus extract (Thymex - L) on the parameters of humoral immune response (concentration of antibodies to tetanus toxoid - ATTx) and cellular immune response (interleukin 2 - IL-2, interferon γ - IFN-γ and degree of cutaneus basophyl hypersensitivity - CBHR) in rats previously irradiated by X-rays at a dose of 4 or 6 Gy. The studied thymus extract had shown positive effects on IL-2 and IFN-γ serum concentrations in irradiated rats. In the group of rats irradiated with 4 Gy the effects were evident on the 7th day of the trial. Rats irradiated with the higher dose (6 Gy) experienced the positive effects of thymus extract on the 21st day of the experiment. In the skin PHA hypersensitivity test, a positive effect was also recorded, being more pronounced in rats which received the lower irradiation dose. The tested thymus extract had shown a positive effect on the concentration of ATTx as early as the 14th day of the trial.en
dc.description.abstractPojedini sastojci ekstrakta goveđeg timusa imaju imunomodulatorna svojstva i mogu, kod ljudi i životinja, sa suprimiranim funkcijama imunskog sistema (humoralnim i/ili celularnim) dovesti do imunostimulacije. U ovom radu su prikazani rezultati ispitivanja efekata preparata Thymex-L dobijenog iz ekstrakta goveđ eg timusa na parametre humoralnog imunskog odgovora pacova kod kojih je prethodno izvršeno jednokratno ozračivanje X zracima u dozi od 4 ili 6 Gy. Određivani su sledeći parametri: koncentracija interleukina 2 (IL-2), interferona γ (IFN-γ), koncentracija antitela posle vakcinacije i revakcinacije tetanusnim toksoidom (ATTx) i stepen kožne preosetljivosti (CBHR) na biljni mitogen (PHA) Ispitivani ekstrakt je ispoljio pozitivan efekat na koncentraciju IL-2 i IFN-γ u serumu ozračenih pacova. Ovaj pozitivan efekat je, kod grupe pacova koja je primila nižu dozu zračenja, vidljiv već nakon 7. dana eksperimenta, dok je kod pacova ozračenih višom dozom zračenja pozitivan efekat registrovan 21. dana eksperimenta. Pri proceni stepena reakcije kožne preosetljivosti na PHA, registrovan je pozitivan efekat primenjenog ekstrakta timusa i on je bio izraženiji kod jedinki kod kojih je bila primenjena niža doza zračenja. Ispitivani ekstrakt goveđeg timusa je ispoljio pozitivan efekat i na koncentraciju ATTx i to već 14. dana eksperimenta.sr
dc.publisherUniverzitet u Beogradu - Fakultet veterinarske medicine, Beograd
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/143022/RS//
dc.rightsopenAccess
dc.sourceActa Veterinaria-Beograd
dc.subjectbovine thymus extracten
dc.subjectcellular immune responseen
dc.subjecthumoral immune responseen
dc.subjectirradiationen
dc.subjectimmunomodulationen
dc.subjectratsen
dc.titleThe influence of bovine thymic extract on the immune response in irradiated wistar ratsen
dc.titleEfekat ekstrakta goveđeg timusa na imunski odgovor ozračenih wistar pacovasr
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЛазаревић, Миодраг; Поповић, Н.; Јовановић, Милан; Војводић, Данило;
dc.citation.volume59
dc.citation.issue4
dc.citation.spage331
dc.citation.epage347
dc.citation.other59(4): 331-347
dc.citation.rankM23
dc.identifier.wos000270452700002
dc.identifier.doi10.2298/AVB0904331J
dc.identifier.scopus2-s2.0-70350033814
dc.identifier.fulltexthttps://vet-erinar.vet.bg.ac.rs/bitstream/id/1166/612.pdf
dc.type.versionpublishedVersion


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