The Effects of Flunixin Meglumine and L-NAME on the Carrageenan-induced Hyperalgesia in Rats
Apstrakt
Flunixin meglumine (FM) is a potent non-steroidal anti-inflammatory drug used in veterinary clinical practice. Hyperalgesia was induced by mtraplantar (i.pl.) administration of carrageenan (500 mu g) into the rat hind paw. Electronic von Frey apparatus was used to determine paw withdrawal threshold in grams (g). Both, FM (0.095-0.12 mg/kg: s.c.) and N-G-nitro-L-arginine methyl ester (L-NAME 2.5 and 5 mg/kg; i.p.), given 2.5 h after i.pl. injection of carrageenan produced significant dose-dependent antinociceptive effects. When FM (0.095 mg/kg) and subeffective dose of L-NAME (7.5 mg/kg) were co-administered, the anti-nociceptive effect was significantly increased M comparison with the effect of FM alone. L-arginme (10 mg/kg: i.p.) itself did not produce significant effect on carrageenan-induced hyperalgesia, but significantly inhibited the anti-nociceptive effects of both FM and FM + L-NAME combination. The inhibition of production of nitric oxide might be involved in the mechanism of ...the anti-hyperalgesic effect of FM in a model of carrageenan-induced hyperalgesia in rats.
Izvor:
9th Congress of the European Association for Clinical Pharmacology and Therapeutics, 2009, 163-Izdavač:
- Medimond S R L, 40128 Bologna
Kolekcije
Institucija/grupa
Fakultet veterinarske medicineTY - CONF AU - Milovanović, M. AU - Vucković, S. AU - Prostran, Milica AU - Jezdimirović, Milanka AU - Ćupić, Vitomir PY - 2009 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/633 AB - Flunixin meglumine (FM) is a potent non-steroidal anti-inflammatory drug used in veterinary clinical practice. Hyperalgesia was induced by mtraplantar (i.pl.) administration of carrageenan (500 mu g) into the rat hind paw. Electronic von Frey apparatus was used to determine paw withdrawal threshold in grams (g). Both, FM (0.095-0.12 mg/kg: s.c.) and N-G-nitro-L-arginine methyl ester (L-NAME 2.5 and 5 mg/kg; i.p.), given 2.5 h after i.pl. injection of carrageenan produced significant dose-dependent antinociceptive effects. When FM (0.095 mg/kg) and subeffective dose of L-NAME (7.5 mg/kg) were co-administered, the anti-nociceptive effect was significantly increased M comparison with the effect of FM alone. L-arginme (10 mg/kg: i.p.) itself did not produce significant effect on carrageenan-induced hyperalgesia, but significantly inhibited the anti-nociceptive effects of both FM and FM + L-NAME combination. The inhibition of production of nitric oxide might be involved in the mechanism of the anti-hyperalgesic effect of FM in a model of carrageenan-induced hyperalgesia in rats. PB - Medimond S R L, 40128 Bologna C3 - 9th Congress of the European Association for Clinical Pharmacology and Therapeutics T1 - The Effects of Flunixin Meglumine and L-NAME on the Carrageenan-induced Hyperalgesia in Rats SP - 163 UR - https://hdl.handle.net/21.15107/rcub_veterinar_633 ER -
@conference{ author = "Milovanović, M. and Vucković, S. and Prostran, Milica and Jezdimirović, Milanka and Ćupić, Vitomir", year = "2009", abstract = "Flunixin meglumine (FM) is a potent non-steroidal anti-inflammatory drug used in veterinary clinical practice. Hyperalgesia was induced by mtraplantar (i.pl.) administration of carrageenan (500 mu g) into the rat hind paw. Electronic von Frey apparatus was used to determine paw withdrawal threshold in grams (g). Both, FM (0.095-0.12 mg/kg: s.c.) and N-G-nitro-L-arginine methyl ester (L-NAME 2.5 and 5 mg/kg; i.p.), given 2.5 h after i.pl. injection of carrageenan produced significant dose-dependent antinociceptive effects. When FM (0.095 mg/kg) and subeffective dose of L-NAME (7.5 mg/kg) were co-administered, the anti-nociceptive effect was significantly increased M comparison with the effect of FM alone. L-arginme (10 mg/kg: i.p.) itself did not produce significant effect on carrageenan-induced hyperalgesia, but significantly inhibited the anti-nociceptive effects of both FM and FM + L-NAME combination. The inhibition of production of nitric oxide might be involved in the mechanism of the anti-hyperalgesic effect of FM in a model of carrageenan-induced hyperalgesia in rats.", publisher = "Medimond S R L, 40128 Bologna", journal = "9th Congress of the European Association for Clinical Pharmacology and Therapeutics", title = "The Effects of Flunixin Meglumine and L-NAME on the Carrageenan-induced Hyperalgesia in Rats", pages = "163", url = "https://hdl.handle.net/21.15107/rcub_veterinar_633" }
Milovanović, M., Vucković, S., Prostran, M., Jezdimirović, M.,& Ćupić, V.. (2009). The Effects of Flunixin Meglumine and L-NAME on the Carrageenan-induced Hyperalgesia in Rats. in 9th Congress of the European Association for Clinical Pharmacology and Therapeutics Medimond S R L, 40128 Bologna., 163. https://hdl.handle.net/21.15107/rcub_veterinar_633
Milovanović M, Vucković S, Prostran M, Jezdimirović M, Ćupić V. The Effects of Flunixin Meglumine and L-NAME on the Carrageenan-induced Hyperalgesia in Rats. in 9th Congress of the European Association for Clinical Pharmacology and Therapeutics. 2009;:163. https://hdl.handle.net/21.15107/rcub_veterinar_633 .
Milovanović, M., Vucković, S., Prostran, Milica, Jezdimirović, Milanka, Ćupić, Vitomir, "The Effects of Flunixin Meglumine and L-NAME on the Carrageenan-induced Hyperalgesia in Rats" in 9th Congress of the European Association for Clinical Pharmacology and Therapeutics (2009):163, https://hdl.handle.net/21.15107/rcub_veterinar_633 .