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Uticaj toluena na oksidativne procese u krvi pacova

dc.creatorStajković, Silvana
dc.creatorBorozan, Sunčica
dc.creatorGađanski-Omerović, Gordana
dc.date.accessioned2020-06-03T13:16:11Z
dc.date.available2020-06-03T13:16:11Z
dc.date.issued2009
dc.identifier.issn0352-5139
dc.identifier.urihttp://vet-erinar.vet.bg.ac.rs/handle/123456789/635
dc.description.abstractThis study was designed to investigate the effects of toluene treatment on oxidative stress in rat blood. Since toluene metabolism produces reactive oxygen and nitrogen species, it was hypothesized that the toluene treatment would: 1) provoke changes in the activities of antioxidant enzymes, 2) impair the integrity of the cell membrane and 3) induce structural changes in the plasma proteins. Female Wistar rats were treated with toluene intraperitonally, at a daily dose of 0.38 mmol/kg body weight for 12 days, and 5 mmol/kg body weight for 6 days, respectively, with propylene glycol as the carrier. Toluene significantly increased superoxide dismutase activity at low doses, catalase activity at high doses and the level of erythrocytes malondialdehyde in both treated groups when compared to the control group. The nitrite ( ? 2 NO ) level in both treated groups was not different from that in the control animals. Toluene caused oxidative modification of plasma proteins and, consequently, changes in the concentration of glycoproteins and lipoproteins when compared to the control group. The observed alterations indicate that toluene treatment might be involved in free radical processes.en
dc.description.abstractU ovom radu je ispitivan uticaj toluena na oksidativni stres u krvi pacova. S obzirom na to da metabolizam toluena dovodi do stvaranja reaktivnih kiseoničnih i azotovih vrsta, pretpostavljeno je da tretiranje pacova različitim koncentracijama toluena dovodi do 1) promene u aktivnosti enzima antioksidativne odbrane, 2) narušavanja integriteta ćelijske membrane i 3) strukturnih promena kod plazma proteina. Ženke pacova soja Wistar su podeljene u tri grupe: I grupa - kontrolna, II i III grupa - pacovi tretirani i.p. toluenom svakodnevno 12 i 6 dana, dozom od 0,38 mmol/kg telesne mase i 5,0 mmol/kg telesne mese. Toluen je statistički značajno povećavao aktivnost SOD u II grupi i aktivnost CAT u III grupi, dok je sadržaj MDA bio značajno povećan u obe grupe u poređenju sa kontrolnom grupom. Sniženje? 2 NO u obe tretirane grupe nije bilo statistički značajno u odnosu na kontrolnu grupu. Toluen je doveo do oksidativnih promena plazma proteina, a samim tim i do promene koncentracije gliko- i lipoproteina u odnosu na kontrolnu grupu. Dokazane promene ukazuju na to da tretiranje toluenom izaziva slobodno-radikalske procese.sr
dc.publisherSrpsko hemijsko društvo, Beograd
dc.relationProjekat Ministarstva nauke Republike Srbije, br. 1518
dc.rightsopenAccess
dc.sourceJournal of the Serbian Chemical Society
dc.subjecttolueneen
dc.subjectfree radicalsen
dc.subjectantioxidant enzymesen
dc.subjectprotein modificationen
dc.titleThe effect of toluene on oxidative processes in rat blooden
dc.titleUticaj toluena na oksidativne procese u krvi pacovasr
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractГађански-Омеровић, Гордана; Стајковић, Силвана; Борозан, Сунчица; Утицај толуена на оксидативне процесе у крви пацова; Утицај толуена на оксидативне процесе у крви пацова;
dc.citation.volume74
dc.citation.issue1
dc.citation.spage15
dc.citation.epage25
dc.citation.other74(1): 15-25
dc.citation.rankM23
dc.identifier.wos000263036400002
dc.identifier.doi10.2298/JSC0901015S
dc.identifier.scopus2-s2.0-68849101198
dc.identifier.fulltexthttp://veterinar.vet.bg.ac.rs/bitstream/id/1187/634.pdf
dc.identifier.rcubconv_1022
dc.type.versionpublishedVersion


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