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Gastroprotektivni efekat novih antidotskih kombinacija kod pacova akutno trovanih T-2 toksinom

dc.creatorJaćević, Vesna
dc.creatorResanović, Radmila
dc.creatorBočarov-Stančić, Aleksandra
dc.creatorĐorđević, Snežana
dc.creatorDragojević-Simić, Viktorija
dc.creatorVukajlović, Ana
dc.creatorBokonjić, Dubravko
dc.date.accessioned2020-06-03T13:18:59Z
dc.date.available2020-06-03T13:18:59Z
dc.date.issued2010
dc.identifier.issn0567-8315
dc.identifier.urihttp://vet-erinar.vet.bg.ac.rs/handle/123456789/673
dc.description.abstractThe purpose of this experiment was to evaluate the antidotal potencies of methylprednisolone (soluble form, Lemod-solu®), nimesulide, N-acetylcysteine (Fluimucil®) and their combinations in rats treated with 1.0 LD50 (0.23 mg/kg) of trichothecene mycotoxin, T-2 toxin. Their antidotal efficacy was investigated by monitoring their effects on general condition, 24-hour-survival, body weight gain, food and water consumption and pathohistological changes in the gut of Wistar rats acutely treated with a single injection of T-2 toxin during a 4-week period. The highest protective index was obtained with methylprednisolone (2.43). Initial loss of body weight (after first 7 days) was found only in T-2 toxin group. During the whole experiment, in poisoned rats protected by methylprednisolone or methylprednisolone and nimesulide, a significant increase (p lt 0.001) in body weight gain, food and water consumption in comparison with T-2 toxin group was found. At the end of the experiment, N-acetylcysteine, nimesulide and their combination assured higher (p lt 0.05) weight gain, food and water consumption in comparison with T-2 toxin group. Signs of hemorrhagic diathesis and necrosis of the gut crypt epithelium and lymphoid tissues were found in the T-2 toxin group. Some of these histological alterations were presented in the gut of poisoned rats treated by nimesulide, Nacetylcysteine and their combination. The gut of T-2 toxin rats treated with a combination of methylprednisolone and nimesulide and especially methylprednisolone alone had a histological structure similar to the control group. These results clearly show that methylprednisolone, a well-known anti-inflammatory and immunosuppressive drug, exerts the best antidotal effect against T-2 toxin intoxication in rats.en
dc.description.abstractCilj ovog rada je bio da se ispitaju efekti metilprednizolona (solubilni oblik, Lemod-solu®), nimesulida, N-acetilcisteina (Fluimucil®) i njihovih kombinacija kod pacova tretiranih sa 1,0 LD50 (0,23 mg/kg) trihotecenskog mikotoksina T-2. Antidotski efekat je ispitivan praćenjem njihovog uticaja na opšte stanje, 24-voro časovno preživljavanje, telesnu masu, potrošnju hrane i vode i patohistološke promene u digestivnom traktu tokom 4 nedelje, kod pacova, soj Wistar, kojima je jednokratno aplikovan T-2 toksin. Najveći zaštitni efekat ispoljio je metilprednizolon (2,43). Gubitak telesne mase, tokom prvih 7 dana ustanovljen je samo u T-2 toksin grupi. Tokom čitavog eksperimenta, u grupama trovanih pacova koji su štićeni metilprednizolonom ili metilprednizolonom i nimesulidom, ustanovljeno je značajno povećanje (p lt 0,001) telesne mase, potrošnje hrane i vode, u poređenju sa T-2 toksin gropom. Na kraju ispitivanog perioda, N-acetilcistein, nimesulid i njihova kombinacija obezbedili su takođe porast (p lt 0,05) telesne mase, potrošnje hrane i vode u poređenju sa T-2 toksin grupom. Znaci hemoragične dijateze i nekroza epitelnih žlezdica digestivnog trakta uočeni su u T-2 toksin grupi. Blage histološ ke promene bile su prisutne u digestivnom traktu trovanih pacova tretiranih nimesulidom, N-acetilcisteinom i njihovom kombinacijom. Histološka građa digestivnog trakta trovanih pacova koji su štićeni metilprednizolonom i nimesulidom, a posebno sa metilprednizolonom bila je slična kao u kontrolnoj grupi. Prikazani rezultati jasno ukazuju da je metilprednizolon, dobro poznat anti-inflamatorni i imunosupresivni lek, ispoljio najbolji zaštitni efekat kod pacova akutno trovanih T-2 toksinom.sr
dc.publisherUniverzitet u Beogradu - Fakultet veterinarske medicine, Beograd
dc.relationProjekat Ministarstva nauke Republike Srbije, br. 213017
dc.rightsopenAccess
dc.sourceActa veterinaria - Beograd
dc.subjectguten
dc.subjectmethylprednisoloneen
dc.subjectN-acetylcysteineen
dc.subjectnimesulideen
dc.subjectpathohistologyen
dc.subjectT-2 toxinen
dc.titleGastroprotective effects of novel antidotal combination in rats acutely poisoned by T-2 toxinen
dc.titleGastroprotektivni efekat novih antidotskih kombinacija kod pacova akutno trovanih T-2 toksinomsr
dc.typearticle
dc.rights.licenseARR
dcterms.abstractБокоњић, Дубравко; Ресановић, Радмила; Ђорђевић, Снежана; Драгојевић-Симић, Викторија; Вукајловић, Aна; Бочаров-Станчић, Aлександра; Јаћевић, Весна; Гастропротективни ефекат нових антидотских комбинација код пацова акутно трованих Т-2 токсином; Гастропротективни ефекат нових антидотских комбинација код пацова акутно трованих Т-2 токсином;
dc.citation.volume60
dc.citation.issue5-6
dc.citation.spage461
dc.citation.epage478
dc.citation.other60(5-6): 461-478
dc.citation.rankM23
dc.identifier.wos000285772100003
dc.identifier.doi10.2298/AVB1006461J
dc.identifier.scopus2-s2.0-78651265610
dc.identifier.fulltexthttp://veterinar.vet.bg.ac.rs/bitstream/id/1226/672.pdf
dc.identifier.rcubconv_743
dc.type.versionpublishedVersion


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