Immunomodulation induced by pretreatment with 6-hydroxydopamine in the rat
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To produce chemical sympathectomy, Wistar rats were pretreated with 6-hydroxydopamine (6-OHDA), a substance known to produce general depletion of catecholamines from their stores. 6-OHDA was injected either intracerebroventricularly (i.c.v.) or intraperitoneally (i.p.) into animals immunized with bovine serum albumin, sheep red blood cells and guinea-pig spinal cord. The results obtained indicate that pretreatment with 6-OHDA, decrease the number of plaque-forming cells (PFC), severity of clinical signs of experimental allergic encephalomyelitis (EAE) and suppressed skin sensitivity reaction.
Keywords:Catecholamines / Hydroxydopamines / Immune system / Norepinephrine
Source:Vojnosanitetski Pregled, 1994, 51, 4 SUPPL., 13-16
- Vojnomedicinska akademija - Institut za naučne informacije, Beograd