Possibilities of applying pharmacological stress testing in assessment of heart functional capacity in dogs

Abstract

Systolic and diastolic heart functions, evaluated using echocardiography, do not reflect the functional capacity of the patient and they cannot explain the occurrence of symptoms during a certain degree of activity. Evaluation of the functional capacity is an integral part of cardiological examinations in human medicine. Functional examinations of the heart can be carried out using the body burden test or pharmacologically. Investigations carried out so far into canine cardiology have not contributed to the clinical implementation of functional heart examinations in dogs. Pharmacological stress testing is an optimal way to perform a functional heart examination in dogs. Since it reflects the effects of moderate physical activity, dobutamine has been recommended as the medicine of choice for provoking a pharmacological stress test. This work presents a review of the results of the most important investigations, as well as our own investigations, of the application of the dobutamine stress test (DST) in dogs, and the problems in investigations so far have been considered and future directions for DST investigations pointed out. .

Sistolna i dijastolna srčana funkcija, procenjene ehokardiografski, ne odražavaju funkcionalni kapacitet pacijenta, niti mogu da objasne pojavu simptoma pri određenom stepenu aktivnosti. Procena funkcionalnog kapaciteta je sastavni deo kardioloških pregleda u humanoj medicini. Funkcionalno ispitivanje srca može da se sprovede testom opterećenja ili farmakološki. Dosadašnja istraživanja u kardiologiji pasa nisu doprinela kliničkoj upotrebi funkcionalnog ispitivanja srca kod pasa. Farmakološki stres test je optimalan način funkcionalnog ispitivanja srca kod pasa. Budući da podražava efekte umerene fizičke aktivnosti, dobutamin je predložen kao lek izbora za izazivanje farmakološkog stres testa. U ovom radu su dati pregledi rezultata najznačajnijih istraživanja, kao i naših istraživanja primene dobutamin stres testa (DST) kod pasa, sagledani su nedostatci dosadašnjih istraživanja i ukazano je na buduće pravce istraživanja DST.