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Uticaj ekstrakta podzemnih organa Helleborus odorus w. et K. na crvenu krvnu sliku Wistar pacova

dc.creatorDavidović, Vesna
dc.creatorLazarević, Miodrag
dc.creatorJoksimović-Todorović, Mirjana
dc.creatorMaksimović, Zoran
dc.creatorJovanović, Milan
dc.creatorMiljas, Niko
dc.date.accessioned2020-06-03T13:21:23Z
dc.date.available2020-06-03T13:21:23Z
dc.date.issued2010
dc.identifier.issn0350-2457
dc.identifier.urihttp://vet-erinar.vet.bg.ac.rs/handle/123456789/707
dc.description.abstractThis paper presents the results of investigations of parameter values of the red blood cell count in Wistar rats, after intramuscular application of rhizome and root extract of Helleborus odorus W. et K (HE). The trial was conducted in experimental conditions on 49 Wistar rats divided into 7 groups with 7 animals per unit (control and six experimental groups). The control group was treated by an intramuscular injection of sterile saline (0.25 ml/100 g BM). For the purpose of determing the duration of the HE effects, the animals were injected with a dose of 10 mg/100 g BMand blood was collected by cardial taps after 24, 48 and 72 hrs. Moreover, we investigated the influence of elevated temperatures on the noted HE extract effects, 24 hrs after the application of the inactivated (56oC 30 min) or denaturized (100oC 5 min) extract, as well as the influence of dialyzed HE. The obtained results of haematological analyses have pointed out the weak hemolyses activity of the extract. In all experimental groups, the erythrocyte count was decreased, but remained within reference values. Haemoglobin concentration and haematocrit values in the experimental and the control groups of rats were decreased in comparison to the physiological values, while the applied extract did not significantly affect the examined parameters. .en
dc.description.abstractU ovom radu su prikazani rezultati ispitivanja vrednosti parametara crvene krvne slike pacova soja Wistar, nakon intramuskularne aplikacije ekstrakta rizoma i korena Helleborus odorus W. et K. Ogled je izveden u eksperimentalnim uslovima na 49 pacova soja Wistar, podeljenih u 7 grupa sa po 7 jedinki (jedna kontrolna i šest oglednih grupa). Kontrolnoj grupi pacova je intramuskularno aplikovan fiziološki rastvor (0,25 ml/100 g t.m.). U cilju određivanja dužine trajanja efekata ekstrakta, pacovima je aplikovan tečni ekstrakt podzemnih organa kukureka u koncentraciji od 10 mg/100 g t.m., a krv je uzorkovana kardijalnom punkcijom nakon 24h, 48h i 72h. Ispitivan je i uticaj ekstrakta izlaganog povišenoj temperaturi na uočene efekte, 24h posle aplikacije inaktivisanog (56oC 30 min) ili denaturisanog ekstrakta (100oC 5 min), kao i efekat dijalizata ekstrakta. Dobijeni rezultati hematoloških analiza su ukazali na slabu hemolitičku aktivnost ekstrakta. Kod svih oglednih grupa, prosečan broj eritrocita bio je smanjen, ali se održao u granicama referentnih vrednosti. Zabeležene koncentracije hemoglobina i hematokrita u krvi pacova kontrolne i oglednih grupa bile su niže u odnosu na fiziološke vrednosti, pri čemu korišćeni ekstrakt nije značajno uticao na ispitivane parametre.sr
dc.publisherUniverzitet u Beogradu - Fakultet veterinarske medicine, Beograd
dc.rightsopenAccess
dc.sourceVeterinarski glasnik
dc.subjectHelleborus sp.en
dc.subjectred blood cell count parametersen
dc.subjectratsen
dc.subjectkukureksr
dc.subjectcrvena krvna lozasr
dc.subjectpacovisr
dc.titleInfluence of Helleborus odorus W. et K. underground parts extracts on red blood pictures of Wistar ratsen
dc.titleUticaj ekstrakta podzemnih organa Helleborus odorus w. et K. na crvenu krvnu sliku Wistar pacovasr
dc.typearticle
dc.rights.licenseBY
dcterms.abstractЈовановић, Милан; Лазаревић, Миодраг; Максимовић, Зоран; Давидовић, Весна; Јоксимовић-Тодоровић, Мирјана; Миљас, Нико;
dc.citation.volume64
dc.citation.issue3-4
dc.citation.spage219
dc.citation.epage229
dc.citation.other64(3-4): 219-229
dc.citation.rankM51
dc.identifier.doi10.2298/VETGL1004219D
dc.identifier.fulltexthttp://veterinar.vet.bg.ac.rs/bitstream/id/1256/706.pdf
dc.identifier.rcubconv_239
dc.type.versionpublishedVersion


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