Investigation of comparative efficacy of eugenol and benzyl benzoate in therapy of sheep mange
Komparativno ispitivanje efikasnosti eugenola i benzil-benzoata u terapiji šuge ovaca
Apstrakt
The acaricide efficacy, tolerance and safety of eugenol (10 and 20 %) in the treatment of sarcoptic mange in sheep have been investigated. The results were compared with those corresponding for benzyl benzoate (25 %), which was applied to sheep in the same way. The treatment was applied on sheep three times in one-week intervals. Skin scrapings were sampled seven days after each treatment, as well as twenty-eight days following the third one. The changes on the skin were quantified and the mean recovery response (MRR) was calculated. The clinical efficacy was assessed according to the MRR and the number of mites in the samples. Following the first treatment 10%eugenol was not significantly less efficacious in comparison with the higher concentration. Having been applied twice 20% eugenol was significantly more efficacious when compared to the lower concentration, which remained the same seven and twenty-eight days after the third application. The efficacy of 10% eugenol in the therapy ...of mange was significantly higher in comparison with benzyl benzoate following one, two or three administrations. The efficacy of benzyl benzoate four weeks after the third treatment was still significantly lower in comparison with 10% eugenol. The efficacy of 20% eugenol was significantly higher in comparison with its lower concentration as well as that of benzyl benzoate, following the second, and seven and twenty-eight days after the third one. No signs of local or systemic intolerance were observed in sheep treated with either 10 or 20% eugenol, or 25 % benzyl benzoate. .
Ispitivana je akaricidna efikasnost, podnošljivost i bezbednost eugenola (10 i 20%) u lečenju sarkoptes-šuge ovaca. Rezultati ispitivanja upoređivani su sa odgovarajućim podacima dobijenim posle primene benzil-benzoata (25 %) primenjivanog na isti način u lečenju šuge ovaca. Tretiranje ovaca je obavljeno tri puta u vremenskom intervalu od po sedam dana. U cilju provere efikasnosti primenjenih lekova uzorci kože su uzimani 7 dana posle svakog tretmana, kao i 28 dana posle trećeg tretmana. Promene na koži izazvane šugarcima su kvantifikovane, na osnovu čega je određivan klinički skor (mean recovery response, MRR). Klinička efikasnost lekova procenjivana je na osnovu povlačenja kliničkih simptoma šuge kao i na osnovu broja prisutnih šugaraca u uzorcima strugotine kože. Eugenol u koncentraciji od 10 % posle prvog tretmana nije imao značajno manju efikasnost u odnosu na veću koncentraciju. Posle drugog tretmana efikasnost eugenola od 20 % bila je statistički značajno veća u odnosu na nižu k...oncentraciju, što je dokazano i 7 i 28 dana nakon trećeg tretmana. Eugenol je u koncentraciji od 10 % imao statistički značajno veću efikasnost od benzilbenzoata u terapiji šuge ovaca, kako posle prvog, tako i posle drugog i trećeg tretmana. Proverom efikasnosti benzil-benzoata posle 4 nedelje od trećeg tretmana dokazano je da je ona i dalje značajno manja u odnosu na eugenol u koncentraciji od 10 %. Efikasnost eugenola u koncentraciji od 20 % u lečenju sarkoptes-šuge ovaca bila je statistički značajno veća u odnosu na efikasnost eugenola u koncentraciji od 10 %, kao i benzil-benzoat, i posle drugog tretmana i posle 7 i 28 dana posle trećeg tretmana. Tokom trokratne primene eugenola u koncentraciji od 10 i 20%i benzil-benzoata u koncentraciji od 25% nisu zapaženi bilo kakvi znaci lokalne i sistemske nepodnošljivosti kod tretiranih ovaca.
Ključne reči:
eugenol / benzyl benzoate / mange / Sarcoptes scabiei / sheep / eugenol / benzil-benzoat / šuga / Sarcoptes scabiei / ovceIzvor:
Veterinarski Glasnik, 2010, 64, 3-4, 177-185Izdavač:
- Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
Kolekcije
Institucija/grupa
Fakultet veterinarske medicineTY - JOUR AU - Jezdimirović, Milanka AU - Aleksić, Nevenka AU - Radojičić, Biljana PY - 2010 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/742 AB - The acaricide efficacy, tolerance and safety of eugenol (10 and 20 %) in the treatment of sarcoptic mange in sheep have been investigated. The results were compared with those corresponding for benzyl benzoate (25 %), which was applied to sheep in the same way. The treatment was applied on sheep three times in one-week intervals. Skin scrapings were sampled seven days after each treatment, as well as twenty-eight days following the third one. The changes on the skin were quantified and the mean recovery response (MRR) was calculated. The clinical efficacy was assessed according to the MRR and the number of mites in the samples. Following the first treatment 10%eugenol was not significantly less efficacious in comparison with the higher concentration. Having been applied twice 20% eugenol was significantly more efficacious when compared to the lower concentration, which remained the same seven and twenty-eight days after the third application. The efficacy of 10% eugenol in the therapy of mange was significantly higher in comparison with benzyl benzoate following one, two or three administrations. The efficacy of benzyl benzoate four weeks after the third treatment was still significantly lower in comparison with 10% eugenol. The efficacy of 20% eugenol was significantly higher in comparison with its lower concentration as well as that of benzyl benzoate, following the second, and seven and twenty-eight days after the third one. No signs of local or systemic intolerance were observed in sheep treated with either 10 or 20% eugenol, or 25 % benzyl benzoate. . AB - Ispitivana je akaricidna efikasnost, podnošljivost i bezbednost eugenola (10 i 20%) u lečenju sarkoptes-šuge ovaca. Rezultati ispitivanja upoređivani su sa odgovarajućim podacima dobijenim posle primene benzil-benzoata (25 %) primenjivanog na isti način u lečenju šuge ovaca. Tretiranje ovaca je obavljeno tri puta u vremenskom intervalu od po sedam dana. U cilju provere efikasnosti primenjenih lekova uzorci kože su uzimani 7 dana posle svakog tretmana, kao i 28 dana posle trećeg tretmana. Promene na koži izazvane šugarcima su kvantifikovane, na osnovu čega je određivan klinički skor (mean recovery response, MRR). Klinička efikasnost lekova procenjivana je na osnovu povlačenja kliničkih simptoma šuge kao i na osnovu broja prisutnih šugaraca u uzorcima strugotine kože. Eugenol u koncentraciji od 10 % posle prvog tretmana nije imao značajno manju efikasnost u odnosu na veću koncentraciju. Posle drugog tretmana efikasnost eugenola od 20 % bila je statistički značajno veća u odnosu na nižu koncentraciju, što je dokazano i 7 i 28 dana nakon trećeg tretmana. Eugenol je u koncentraciji od 10 % imao statistički značajno veću efikasnost od benzilbenzoata u terapiji šuge ovaca, kako posle prvog, tako i posle drugog i trećeg tretmana. Proverom efikasnosti benzil-benzoata posle 4 nedelje od trećeg tretmana dokazano je da je ona i dalje značajno manja u odnosu na eugenol u koncentraciji od 10 %. Efikasnost eugenola u koncentraciji od 20 % u lečenju sarkoptes-šuge ovaca bila je statistički značajno veća u odnosu na efikasnost eugenola u koncentraciji od 10 %, kao i benzil-benzoat, i posle drugog tretmana i posle 7 i 28 dana posle trećeg tretmana. Tokom trokratne primene eugenola u koncentraciji od 10 i 20%i benzil-benzoata u koncentraciji od 25% nisu zapaženi bilo kakvi znaci lokalne i sistemske nepodnošljivosti kod tretiranih ovaca. PB - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd T2 - Veterinarski Glasnik T1 - Investigation of comparative efficacy of eugenol and benzyl benzoate in therapy of sheep mange T1 - Komparativno ispitivanje efikasnosti eugenola i benzil-benzoata u terapiji šuge ovaca VL - 64 IS - 3-4 SP - 177 EP - 185 DO - 10.2298/VETGL1004177J ER -
@article{ author = "Jezdimirović, Milanka and Aleksić, Nevenka and Radojičić, Biljana", year = "2010", abstract = "The acaricide efficacy, tolerance and safety of eugenol (10 and 20 %) in the treatment of sarcoptic mange in sheep have been investigated. The results were compared with those corresponding for benzyl benzoate (25 %), which was applied to sheep in the same way. The treatment was applied on sheep three times in one-week intervals. Skin scrapings were sampled seven days after each treatment, as well as twenty-eight days following the third one. The changes on the skin were quantified and the mean recovery response (MRR) was calculated. The clinical efficacy was assessed according to the MRR and the number of mites in the samples. Following the first treatment 10%eugenol was not significantly less efficacious in comparison with the higher concentration. Having been applied twice 20% eugenol was significantly more efficacious when compared to the lower concentration, which remained the same seven and twenty-eight days after the third application. The efficacy of 10% eugenol in the therapy of mange was significantly higher in comparison with benzyl benzoate following one, two or three administrations. The efficacy of benzyl benzoate four weeks after the third treatment was still significantly lower in comparison with 10% eugenol. The efficacy of 20% eugenol was significantly higher in comparison with its lower concentration as well as that of benzyl benzoate, following the second, and seven and twenty-eight days after the third one. No signs of local or systemic intolerance were observed in sheep treated with either 10 or 20% eugenol, or 25 % benzyl benzoate. ., Ispitivana je akaricidna efikasnost, podnošljivost i bezbednost eugenola (10 i 20%) u lečenju sarkoptes-šuge ovaca. Rezultati ispitivanja upoređivani su sa odgovarajućim podacima dobijenim posle primene benzil-benzoata (25 %) primenjivanog na isti način u lečenju šuge ovaca. Tretiranje ovaca je obavljeno tri puta u vremenskom intervalu od po sedam dana. U cilju provere efikasnosti primenjenih lekova uzorci kože su uzimani 7 dana posle svakog tretmana, kao i 28 dana posle trećeg tretmana. Promene na koži izazvane šugarcima su kvantifikovane, na osnovu čega je određivan klinički skor (mean recovery response, MRR). Klinička efikasnost lekova procenjivana je na osnovu povlačenja kliničkih simptoma šuge kao i na osnovu broja prisutnih šugaraca u uzorcima strugotine kože. Eugenol u koncentraciji od 10 % posle prvog tretmana nije imao značajno manju efikasnost u odnosu na veću koncentraciju. Posle drugog tretmana efikasnost eugenola od 20 % bila je statistički značajno veća u odnosu na nižu koncentraciju, što je dokazano i 7 i 28 dana nakon trećeg tretmana. Eugenol je u koncentraciji od 10 % imao statistički značajno veću efikasnost od benzilbenzoata u terapiji šuge ovaca, kako posle prvog, tako i posle drugog i trećeg tretmana. Proverom efikasnosti benzil-benzoata posle 4 nedelje od trećeg tretmana dokazano je da je ona i dalje značajno manja u odnosu na eugenol u koncentraciji od 10 %. Efikasnost eugenola u koncentraciji od 20 % u lečenju sarkoptes-šuge ovaca bila je statistički značajno veća u odnosu na efikasnost eugenola u koncentraciji od 10 %, kao i benzil-benzoat, i posle drugog tretmana i posle 7 i 28 dana posle trećeg tretmana. Tokom trokratne primene eugenola u koncentraciji od 10 i 20%i benzil-benzoata u koncentraciji od 25% nisu zapaženi bilo kakvi znaci lokalne i sistemske nepodnošljivosti kod tretiranih ovaca.", publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd", journal = "Veterinarski Glasnik", title = "Investigation of comparative efficacy of eugenol and benzyl benzoate in therapy of sheep mange, Komparativno ispitivanje efikasnosti eugenola i benzil-benzoata u terapiji šuge ovaca", volume = "64", number = "3-4", pages = "177-185", doi = "10.2298/VETGL1004177J" }
Jezdimirović, M., Aleksić, N.,& Radojičić, B.. (2010). Investigation of comparative efficacy of eugenol and benzyl benzoate in therapy of sheep mange. in Veterinarski Glasnik Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 64(3-4), 177-185. https://doi.org/10.2298/VETGL1004177J
Jezdimirović M, Aleksić N, Radojičić B. Investigation of comparative efficacy of eugenol and benzyl benzoate in therapy of sheep mange. in Veterinarski Glasnik. 2010;64(3-4):177-185. doi:10.2298/VETGL1004177J .
Jezdimirović, Milanka, Aleksić, Nevenka, Radojičić, Biljana, "Investigation of comparative efficacy of eugenol and benzyl benzoate in therapy of sheep mange" in Veterinarski Glasnik, 64, no. 3-4 (2010):177-185, https://doi.org/10.2298/VETGL1004177J . .