A study of selenium genotoxicity in the micronucleus test on mice
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Genotoxicological characterization of sodium selenite in the micronucleus test on BALB/c mice showed that a very small dose (0.2 mg/kg body weight), as well as higher doses (2.0 and 10.0 mg/kg body weight), applied intramuscularly, induced higher micronuclei counts (11.20 ± 1.92; 23.20 ± 3.42; 40.00 ± 4.00) in polychromatic erythrocytes of the bone marrow. The count of induced micronuclei is statistically significant (P lt 0.001) compared to that of spontaneous micronuclei (2.25 ± 1.49) found in mice inoculated with physiological saline solution. Therefore, much care should be taken when selenium preparations are used alone or in combination with vitamin E in the prevention or therapy of different pathological states due to potential genotoixc effects.
Keywords:selenium genotoxicity / micronucleus test / bone marrow cells / polychromatic erythrocytes / BALB/c mice
Source:Acta veterinaria - Beograd, 1996, 46, 2-3, 161-165
- Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd