A study of selenium genotoxicity in the micronucleus test on mice
Apstrakt
Genotoxicological characterization of sodium selenite in the micronucleus test on BALB/c mice showed that a very small dose (0.2 mg/kg body weight), as well as higher doses (2.0 and 10.0 mg/kg body weight), applied intramuscularly, induced higher micronuclei counts (11.20 ± 1.92; 23.20 ± 3.42; 40.00 ± 4.00) in polychromatic erythrocytes of the bone marrow. The count of induced micronuclei is statistically significant (P lt 0.001) compared to that of spontaneous micronuclei (2.25 ± 1.49) found in mice inoculated with physiological saline solution. Therefore, much care should be taken when selenium preparations are used alone or in combination with vitamin E in the prevention or therapy of different pathological states due to potential genotoixc effects.
Ključne reči:
selenium genotoxicity / micronucleus test / bone marrow cells / polychromatic erythrocytes / BALB/c miceIzvor:
Acta Veterinaria-Beograd, 1996, 46, 2-3, 161-165Izdavač:
- Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
Kolekcije
Institucija/grupa
Fakultet veterinarske medicineTY - JOUR AU - Rusov, C AU - Živković, R. AU - Soldatović, Bogosav AU - Jojic-Malicević, L AU - Stanimirović, Zoran PY - 1996 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/75 AB - Genotoxicological characterization of sodium selenite in the micronucleus test on BALB/c mice showed that a very small dose (0.2 mg/kg body weight), as well as higher doses (2.0 and 10.0 mg/kg body weight), applied intramuscularly, induced higher micronuclei counts (11.20 ± 1.92; 23.20 ± 3.42; 40.00 ± 4.00) in polychromatic erythrocytes of the bone marrow. The count of induced micronuclei is statistically significant (P lt 0.001) compared to that of spontaneous micronuclei (2.25 ± 1.49) found in mice inoculated with physiological saline solution. Therefore, much care should be taken when selenium preparations are used alone or in combination with vitamin E in the prevention or therapy of different pathological states due to potential genotoixc effects. PB - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd T2 - Acta Veterinaria-Beograd T1 - A study of selenium genotoxicity in the micronucleus test on mice VL - 46 IS - 2-3 SP - 161 EP - 165 UR - https://hdl.handle.net/21.15107/rcub_veterinar_75 ER -
@article{ author = "Rusov, C and Živković, R. and Soldatović, Bogosav and Jojic-Malicević, L and Stanimirović, Zoran", year = "1996", abstract = "Genotoxicological characterization of sodium selenite in the micronucleus test on BALB/c mice showed that a very small dose (0.2 mg/kg body weight), as well as higher doses (2.0 and 10.0 mg/kg body weight), applied intramuscularly, induced higher micronuclei counts (11.20 ± 1.92; 23.20 ± 3.42; 40.00 ± 4.00) in polychromatic erythrocytes of the bone marrow. The count of induced micronuclei is statistically significant (P lt 0.001) compared to that of spontaneous micronuclei (2.25 ± 1.49) found in mice inoculated with physiological saline solution. Therefore, much care should be taken when selenium preparations are used alone or in combination with vitamin E in the prevention or therapy of different pathological states due to potential genotoixc effects.", publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd", journal = "Acta Veterinaria-Beograd", title = "A study of selenium genotoxicity in the micronucleus test on mice", volume = "46", number = "2-3", pages = "161-165", url = "https://hdl.handle.net/21.15107/rcub_veterinar_75" }
Rusov, C., Živković, R., Soldatović, B., Jojic-Malicević, L.,& Stanimirović, Z.. (1996). A study of selenium genotoxicity in the micronucleus test on mice. in Acta Veterinaria-Beograd Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 46(2-3), 161-165. https://hdl.handle.net/21.15107/rcub_veterinar_75
Rusov C, Živković R, Soldatović B, Jojic-Malicević L, Stanimirović Z. A study of selenium genotoxicity in the micronucleus test on mice. in Acta Veterinaria-Beograd. 1996;46(2-3):161-165. https://hdl.handle.net/21.15107/rcub_veterinar_75 .
Rusov, C, Živković, R., Soldatović, Bogosav, Jojic-Malicević, L, Stanimirović, Zoran, "A study of selenium genotoxicity in the micronucleus test on mice" in Acta Veterinaria-Beograd, 46, no. 2-3 (1996):161-165, https://hdl.handle.net/21.15107/rcub_veterinar_75 .