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dc.creatorRusov, C
dc.creatorŽivković, R.
dc.creatorSoldatović, Bogosav
dc.creatorJojic-Malicević, L
dc.creatorStanimirović, Zoran
dc.date.accessioned2020-06-03T12:36:35Z
dc.date.available2020-06-03T12:36:35Z
dc.date.issued1996
dc.identifier.issn0567-8315
dc.identifier.urihttp://vet-erinar.vet.bg.ac.rs/handle/123456789/75
dc.description.abstractGenotoxicological characterization of sodium selenite in the micronucleus test on BALB/c mice showed that a very small dose (0.2 mg/kg body weight), as well as higher doses (2.0 and 10.0 mg/kg body weight), applied intramuscularly, induced higher micronuclei counts (11.20 ± 1.92; 23.20 ± 3.42; 40.00 ± 4.00) in polychromatic erythrocytes of the bone marrow. The count of induced micronuclei is statistically significant (P lt 0.001) compared to that of spontaneous micronuclei (2.25 ± 1.49) found in mice inoculated with physiological saline solution. Therefore, much care should be taken when selenium preparations are used alone or in combination with vitamin E in the prevention or therapy of different pathological states due to potential genotoixc effects.en
dc.publisherUniverzitet u Beogradu - Fakultet veterinarske medicine, Beograd
dc.rightsrestrictedAccess
dc.sourceActa veterinaria - Beograd
dc.subjectselenium genotoxicityen
dc.subjectmicronucleus testen
dc.subjectbone marrow cellsen
dc.subjectpolychromatic erythrocytesen
dc.subjectBALB/c miceen
dc.titleA study of selenium genotoxicity in the micronucleus test on miceen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСолдатовић, Богосав; Станимировић, Зоран; Јојиц-Малицевић, Л; Живковић, Р.; Русов, Ц;
dc.citation.volume46
dc.citation.issue2-3
dc.citation.spage161
dc.citation.epage165
dc.citation.other46(2-3): 161-165
dc.identifier.wosA1996UW08300013
dc.identifier.scopus2-s2.0-3042898469
dc.identifier.rcubconv_2606
dc.type.versionpublishedVersion


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