dc.creator | Rusov, C | |
dc.creator | Živković, R. | |
dc.creator | Soldatović, Bogosav | |
dc.creator | Jojic-Malicević, L | |
dc.creator | Stanimirović, Zoran | |
dc.date.accessioned | 2020-06-03T12:36:35Z | |
dc.date.available | 2020-06-03T12:36:35Z | |
dc.date.issued | 1996 | |
dc.identifier.issn | 0567-8315 | |
dc.identifier.uri | https://vet-erinar.vet.bg.ac.rs/handle/123456789/75 | |
dc.description.abstract | Genotoxicological characterization of sodium selenite in the micronucleus test on BALB/c mice showed that a very small dose (0.2 mg/kg body weight), as well as higher doses (2.0 and 10.0 mg/kg body weight), applied intramuscularly, induced higher micronuclei counts (11.20 ± 1.92; 23.20 ± 3.42; 40.00 ± 4.00) in polychromatic erythrocytes of the bone marrow. The count of induced micronuclei is statistically significant (P lt 0.001) compared to that of spontaneous micronuclei (2.25 ± 1.49) found in mice inoculated with physiological saline solution. Therefore, much care should be taken when selenium preparations are used alone or in combination with vitamin E in the prevention or therapy of different pathological states due to potential genotoixc effects. | en |
dc.publisher | Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd | |
dc.rights | restrictedAccess | |
dc.source | Acta Veterinaria-Beograd | |
dc.subject | selenium genotoxicity | en |
dc.subject | micronucleus test | en |
dc.subject | bone marrow cells | en |
dc.subject | polychromatic erythrocytes | en |
dc.subject | BALB/c mice | en |
dc.title | A study of selenium genotoxicity in the micronucleus test on mice | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Солдатовић, Богосав; Станимировић, Зоран; Јојиц-Малицевић, Л; Живковић, Р.; Русов, Ц; | |
dc.citation.volume | 46 | |
dc.citation.issue | 2-3 | |
dc.citation.spage | 161 | |
dc.citation.epage | 165 | |
dc.citation.other | 46(2-3): 161-165 | |
dc.identifier.wos | A1996UW08300013 | |
dc.identifier.scopus | 2-s2.0-3042898469 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_veterinar_75 | |
dc.type.version | publishedVersion | |