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dc.creatorSpasojević, Nataša
dc.creatorJovanović, P.
dc.creatorSpasojević-Tišma, Vera
dc.creatorĐelić, Ninoslav
dc.creatorDronjak, Slađana
dc.date.accessioned2020-06-03T13:25:18Z
dc.date.available2020-06-03T13:25:18Z
dc.date.issued2011
dc.identifier.issn0354-4664
dc.identifier.urihttps://vet-erinar.vet.bg.ac.rs/handle/123456789/763
dc.description.abstractIt is well known that antidepressants affect central monoaminergic neurotransmission and that they also modulate hormone release in peripheral tissues. Repeated maprotiline (a noradrenaline reuptake inhibitor) and fluoxetine (a serotonin reuptake inhibitor) treatment on gene expression of the catecholamine biosynthetic enzymes were examined in rat atria and ventricles in vivo. Maprotiline decreased the gene expression of tyrosine hydroxylase (TH) and dopamineβ-hydroxylase (DBH) in the rat atrium. Fluoxetine increased gene expression of TH and DBH, but not of phenylethanolamine N-methyltransferase (PNMT). Chronic application of antidepressants did not change the expression of these enzymes in the ventricles. We conclude that repeated administration of fluoxetine enhances gene transcription of TH and DBH and subsequently stimulates noradrenaline synthesis in rat atria in vivo.en
dc.publisherSrpsko biološko društvo, Beograd, i dr.
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173023/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173044/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceArchives of Biological Sciences
dc.subjectantidepressantsen
dc.subjectcatecholamine enzymesen
dc.subjectgene expressionen
dc.subjectatriaen
dc.subjectventriclesen
dc.subjectratsen
dc.titleDifferential in vivo regulation of TH and DBH mRNA in rat atria by maprotiline and fluoxetineen
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractСпасојевић-Тишма, Вера; Спасојевић, Наташа; Јовановић, П.; Ђелић, Нинослав; Дроњак, Слађана;
dc.citation.volume63
dc.citation.issue3
dc.citation.spage597
dc.citation.epage601
dc.citation.other63(3): 597-601
dc.citation.rankM23
dc.identifier.wos000294400500010
dc.identifier.doi10.2298/ABS1103597S
dc.identifier.scopus2-s2.0-79961180596
dc.identifier.fulltexthttps://vet-erinar.vet.bg.ac.rs/bitstream/id/1304/762.pdf
dc.type.versionpublishedVersion


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