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dc.creatorKojić, Z.
dc.creatorGopcević, K.
dc.creatorMarinković, Darko
dc.creatorTasić, G.
dc.date.accessioned2020-06-03T13:25:30Z
dc.date.available2020-06-03T13:25:30Z
dc.date.issued2011
dc.identifier.issn0862-8408
dc.identifier.urihttp://vet-erinar.vet.bg.ac.rs/handle/123456789/766
dc.description.abstractAngiotensin converting enzyme inhibitors are widely used in therapy of cardiovascular diseases. However, the consensus on effects of these inhibitors in control of myocardial oxygen consumption during the process of experimental hypercholesterolemia and under the condition of endothelial dysfunction has not been reached. Here we examined effects of captopril, an angiotensin converting enzyme inhibitor, on serum lipid levels and oxygen consumption rate in mitochondria isolated from heart of rabbits treated by hypercholesterolemic diet. During the twelve-week period, the Chinchilla male rabbits were daily treated by saline (controls); 1 % cholesterol diet; 5 mg/kg/day captopril or 1 % cholesterol + 5 mg/kg/day captopril. Total- and high-density lipoprotein cholesterol and triglyceride in serum were measured spectrophotometricly. The left ventricle mitochondrial fraction was isolated and myocardial oxygen consumption was measured by Biological Oxygen Monitor. Mitochondria isolated from hearts of rabbits exposed to hypercholesterolemic diet showed significantly reduced respiration rates (state 3 and state 4) with altering adenosine diphosphate/oxygen ratio, whereas the respiratory control ratio was not affected when compared to controls. Mitochondria from cholesterol/captopril-treated animals showed significantly reduced respiration rates without altering adenosine diphosphate/oxygen ratio index or respiratory control ratio. Although captopril did not exert the favorable effect on serum lipid levels in cholesterol-treated animals, it restored the mitochondrial oxygen consumption. Further studies should be performed to define the underlying physiological and/or pathophysiological mechanisms and clinical implications.en
dc.publisherAcad Sciences Czech Republic, Inst Physiology, Prague 4
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175043/RS//
dc.rightsopenAccess
dc.sourcePhysiological Research
dc.subjectACE inhibitorsen
dc.subjectMitochondria, Hearten
dc.subjectOxygen consumptionen
dc.subjectHypercholesterolemiaen
dc.subjectRabbitsen
dc.titleEffect of captopril on serum lipid levels and cardiac mitochondrial oxygen consumption in experimentally-induced hypercholesterolemia in rabbitsen
dc.typearticle
dc.rights.licenseBY-NC
dcterms.abstractТасић, Г.; Гопцевић, К.; Маринковић, Дарко; Којић, З.;
dc.citation.volume60
dc.citation.spageS177
dc.citation.epageS184
dc.citation.other60: S177-S184
dc.citation.rankM23
dc.identifier.wos000296334200020
dc.identifier.pmid21777025
dc.identifier.scopus2-s2.0-84856599714
dc.identifier.rcubconv_1797
dc.type.versionpublishedVersion


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