Recent advances in understanding the virulence of enterohemorrhagic Escherichia coli in food
Nova istraživanja virulentnosti enterohemoragičnih Esherichia coli u hrani
Апстракт
Most of the genes recently found in pathogenic E. coli encode various factors which directly determine their virulence and pathotype. Two main virulence factors characteristic for enterohemorrhagic E. coli(EHEC) are attaching/effacing lesions and Stx1/Stx2 toxins. Genes responsible for expression of aforementioned virulence factors are heavily regulated by environmental conditions. Low iron concentration induces massive expression of stx1 gene and subsequent toxin synthesis. Stress response of EHEC to starvation, acid challenge, cold shock and osmotic changes which damage DNA, induce 'SOS' response. This response mediated by Rec A protein not only repairs damaged DNA fragments but also induces conversion of lysogenic bacteriophage lifecycle to lytic phase followed by intensive expression of stx2 genes. Bacterial stress adaptation of E. coli to novel technologies and the potential for stress-associated enhanced virulence need to be addressed in more detail to prevent potential risk of d...isease. An increased understanding of expression of virulence-associated genes will provide information for control of pathogens and increase microbial safety of foods.
Većina gena koji su poslednjih godina utvrđeni kod patogenih E. coli kodiraju različite faktore koji direktno utiču na njihovu virulentnost i pripadnost određenom patotipu. Dva glavna faktora virulencije kod enterohemoragičnih E. coli (EHEC)su attaching/effacing lezije Stx1/Stx2 toksini. Geni odgovorni za ekspresiju pomenutih faktora virulencije pod jakim su uticajem uslova sredine. Niska koncentracija gvožđa indukuje jaku ekspresiju stx1 gena i posledičnu sintezu velike količine Stx1 toksina. Stresni odgovor EHEC na manjak hranljivih supstanci, povećanje kiselosti sredine, izloženost hladnoći kao i na promene osmolarnosti, koji oštećuju DNK, indukuje 'SOS' odgovor. 'SOS' reakcija posredovana Rec A proteinom ne samo da popravlja oštećene fragmente DNK molekula, već i pokreće mehanizam konverzije bakteriofaga integrisanog u hromozom E. coli iz lizogene faze u litički ciklus tokom koga dolazi do intenzivne ekspresije stx2 gena. Da bi se preventirao potencijalni rizik nastanka bolesti, ne...ophodno je detaljno proučavati prilagođavanje E. coli novim tehnologijama pripreme i konzervacije hrane i potencijal za stres-indukovanu virulenciju. Dobro poznavanje ekspresije gena odgovornih za virulenciju obezbediće informacije neophodne za kontrolu patogena i povećaće mikrobiološku bezbednost hrane.
Кључне речи:
EHEC / virulence / gene expression / food / EHEC / virulentnost / genska ekpresija / hranaИзвор:
Tehnologija mesa, 2011, 52, 1, 52-59Издавач:
- Institut za higijenu i tehnologiju mesa, Beograd
Колекције
Институција/група
Fakultet veterinarske medicineTY - JOUR AU - Velebit, Branko AU - Teodorović, Vlado AU - Borović, Branka PY - 2011 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/779 AB - Most of the genes recently found in pathogenic E. coli encode various factors which directly determine their virulence and pathotype. Two main virulence factors characteristic for enterohemorrhagic E. coli(EHEC) are attaching/effacing lesions and Stx1/Stx2 toxins. Genes responsible for expression of aforementioned virulence factors are heavily regulated by environmental conditions. Low iron concentration induces massive expression of stx1 gene and subsequent toxin synthesis. Stress response of EHEC to starvation, acid challenge, cold shock and osmotic changes which damage DNA, induce 'SOS' response. This response mediated by Rec A protein not only repairs damaged DNA fragments but also induces conversion of lysogenic bacteriophage lifecycle to lytic phase followed by intensive expression of stx2 genes. Bacterial stress adaptation of E. coli to novel technologies and the potential for stress-associated enhanced virulence need to be addressed in more detail to prevent potential risk of disease. An increased understanding of expression of virulence-associated genes will provide information for control of pathogens and increase microbial safety of foods. AB - Većina gena koji su poslednjih godina utvrđeni kod patogenih E. coli kodiraju različite faktore koji direktno utiču na njihovu virulentnost i pripadnost određenom patotipu. Dva glavna faktora virulencije kod enterohemoragičnih E. coli (EHEC)su attaching/effacing lezije Stx1/Stx2 toksini. Geni odgovorni za ekspresiju pomenutih faktora virulencije pod jakim su uticajem uslova sredine. Niska koncentracija gvožđa indukuje jaku ekspresiju stx1 gena i posledičnu sintezu velike količine Stx1 toksina. Stresni odgovor EHEC na manjak hranljivih supstanci, povećanje kiselosti sredine, izloženost hladnoći kao i na promene osmolarnosti, koji oštećuju DNK, indukuje 'SOS' odgovor. 'SOS' reakcija posredovana Rec A proteinom ne samo da popravlja oštećene fragmente DNK molekula, već i pokreće mehanizam konverzije bakteriofaga integrisanog u hromozom E. coli iz lizogene faze u litički ciklus tokom koga dolazi do intenzivne ekspresije stx2 gena. Da bi se preventirao potencijalni rizik nastanka bolesti, neophodno je detaljno proučavati prilagođavanje E. coli novim tehnologijama pripreme i konzervacije hrane i potencijal za stres-indukovanu virulenciju. Dobro poznavanje ekspresije gena odgovornih za virulenciju obezbediće informacije neophodne za kontrolu patogena i povećaće mikrobiološku bezbednost hrane. PB - Institut za higijenu i tehnologiju mesa, Beograd T2 - Tehnologija mesa T1 - Recent advances in understanding the virulence of enterohemorrhagic Escherichia coli in food T1 - Nova istraživanja virulentnosti enterohemoragičnih Esherichia coli u hrani VL - 52 IS - 1 SP - 52 EP - 59 UR - https://hdl.handle.net/21.15107/rcub_veterinar_779 ER -
@article{ author = "Velebit, Branko and Teodorović, Vlado and Borović, Branka", year = "2011", abstract = "Most of the genes recently found in pathogenic E. coli encode various factors which directly determine their virulence and pathotype. Two main virulence factors characteristic for enterohemorrhagic E. coli(EHEC) are attaching/effacing lesions and Stx1/Stx2 toxins. Genes responsible for expression of aforementioned virulence factors are heavily regulated by environmental conditions. Low iron concentration induces massive expression of stx1 gene and subsequent toxin synthesis. Stress response of EHEC to starvation, acid challenge, cold shock and osmotic changes which damage DNA, induce 'SOS' response. This response mediated by Rec A protein not only repairs damaged DNA fragments but also induces conversion of lysogenic bacteriophage lifecycle to lytic phase followed by intensive expression of stx2 genes. Bacterial stress adaptation of E. coli to novel technologies and the potential for stress-associated enhanced virulence need to be addressed in more detail to prevent potential risk of disease. An increased understanding of expression of virulence-associated genes will provide information for control of pathogens and increase microbial safety of foods., Većina gena koji su poslednjih godina utvrđeni kod patogenih E. coli kodiraju različite faktore koji direktno utiču na njihovu virulentnost i pripadnost određenom patotipu. Dva glavna faktora virulencije kod enterohemoragičnih E. coli (EHEC)su attaching/effacing lezije Stx1/Stx2 toksini. Geni odgovorni za ekspresiju pomenutih faktora virulencije pod jakim su uticajem uslova sredine. Niska koncentracija gvožđa indukuje jaku ekspresiju stx1 gena i posledičnu sintezu velike količine Stx1 toksina. Stresni odgovor EHEC na manjak hranljivih supstanci, povećanje kiselosti sredine, izloženost hladnoći kao i na promene osmolarnosti, koji oštećuju DNK, indukuje 'SOS' odgovor. 'SOS' reakcija posredovana Rec A proteinom ne samo da popravlja oštećene fragmente DNK molekula, već i pokreće mehanizam konverzije bakteriofaga integrisanog u hromozom E. coli iz lizogene faze u litički ciklus tokom koga dolazi do intenzivne ekspresije stx2 gena. Da bi se preventirao potencijalni rizik nastanka bolesti, neophodno je detaljno proučavati prilagođavanje E. coli novim tehnologijama pripreme i konzervacije hrane i potencijal za stres-indukovanu virulenciju. Dobro poznavanje ekspresije gena odgovornih za virulenciju obezbediće informacije neophodne za kontrolu patogena i povećaće mikrobiološku bezbednost hrane.", publisher = "Institut za higijenu i tehnologiju mesa, Beograd", journal = "Tehnologija mesa", title = "Recent advances in understanding the virulence of enterohemorrhagic Escherichia coli in food, Nova istraživanja virulentnosti enterohemoragičnih Esherichia coli u hrani", volume = "52", number = "1", pages = "52-59", url = "https://hdl.handle.net/21.15107/rcub_veterinar_779" }
Velebit, B., Teodorović, V.,& Borović, B.. (2011). Recent advances in understanding the virulence of enterohemorrhagic Escherichia coli in food. in Tehnologija mesa Institut za higijenu i tehnologiju mesa, Beograd., 52(1), 52-59. https://hdl.handle.net/21.15107/rcub_veterinar_779
Velebit B, Teodorović V, Borović B. Recent advances in understanding the virulence of enterohemorrhagic Escherichia coli in food. in Tehnologija mesa. 2011;52(1):52-59. https://hdl.handle.net/21.15107/rcub_veterinar_779 .
Velebit, Branko, Teodorović, Vlado, Borović, Branka, "Recent advances in understanding the virulence of enterohemorrhagic Escherichia coli in food" in Tehnologija mesa, 52, no. 1 (2011):52-59, https://hdl.handle.net/21.15107/rcub_veterinar_779 .