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Synthesis of antimicrobial monophase silver-doped hydroxyapatite nanopowders for bone tissue engineering

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2011
Authors
Stanić, Vojislav
Janacković, Đorđe
Dimitrijević, Suzana
Tanasković, Sladjana B.
Mitrić, Miodrag
Pavlović, Mirjana S.
Krstić, Aleksandra
Jovanović, Dragoljub
Raicević, Slavica
Article (Published version)
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Abstract
Monophase silver-doped hydroxyapatite (AgxCa10-x(PO4)(6)(OH)(2); 0.002 <= x <= 0.04) nanoparticles were prepared using a neutralization method and investigated with respect to potential medical applications. This method consists of dissolving Ag2O in solution of H3PO4, and the slow addition to suspension of Ca(OH)(2) was applied for the purpose of homogenous distribution of silver ions. Characterization studies from XRD, TEM and FTIR spectra showed that obtained crystals are monophase hydroxyapatites and that particles of all samples are of nano size, with average length of 70nm and about 15-25nm in diameter. Antimicrobial studies have demonstrated that all silver-doped hydroxyapatite samples exhibit excellent antimicrobial activity in vitro against the following pathogens: Staphylococcus aureus, Escherichia coli and Candida albicans. The hydroxyapatite sample with the highest content of silver has shown the highest antimicrobial activity; killed all cells of E. coli and brought to mor...e than 99% reduction in viable counts of S. aureus and C. albicans. The atomic force microscopic studies illustrate that silver-doped hydroxyapatite sample causes considerable morphological changes of microorganism cells which might be the cause of cells death. Hemolysis ratios of the silver-doped hydroxyapatite samples were below 3%, indicating good blood compatibility and that are promising as biomaterials. Crown Copyright

Keywords:
Hydroxyapatite / Silver / Antimicrobial / Bone / Hemolysis / AFM
Source:
Applied Surface Science, 2011, 257, 9, 4510-4518
Publisher:
  • Elsevier, Amsterdam
Projects:
  • Ministry of Science and Environmental Protection of the Republic of Serbia

DOI: 10.1016/j.apsusc.2010.12.113

ISSN: 0169-4332

WoS: 000286459600114

Scopus: 2-s2.0-78951487082
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161
URI
http://vet-erinar.vet.bg.ac.rs/handle/123456789/793
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  • Radovi istraživača / Researcher's publications
Institution
Fakultet veterinarske medicine

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