Show simple item record

dc.creatorStanić, Vojislav
dc.creatorJanacković, Đorđe
dc.creatorDimitrijević, Suzana
dc.creatorTanasković, Sladjana B.
dc.creatorMitrić, Miodrag
dc.creatorPavlović, Mirjana S.
dc.creatorKrstić, Aleksandra
dc.creatorJovanović, Dragoljub
dc.creatorRaicević, Slavica
dc.date.accessioned2020-06-03T13:27:23Z
dc.date.available2020-06-03T13:27:23Z
dc.date.issued2011
dc.identifier.issn0169-4332
dc.identifier.urihttp://vet-erinar.vet.bg.ac.rs/handle/123456789/793
dc.description.abstractMonophase silver-doped hydroxyapatite (AgxCa10-x(PO4)(6)(OH)(2); 0.002 <= x <= 0.04) nanoparticles were prepared using a neutralization method and investigated with respect to potential medical applications. This method consists of dissolving Ag2O in solution of H3PO4, and the slow addition to suspension of Ca(OH)(2) was applied for the purpose of homogenous distribution of silver ions. Characterization studies from XRD, TEM and FTIR spectra showed that obtained crystals are monophase hydroxyapatites and that particles of all samples are of nano size, with average length of 70nm and about 15-25nm in diameter. Antimicrobial studies have demonstrated that all silver-doped hydroxyapatite samples exhibit excellent antimicrobial activity in vitro against the following pathogens: Staphylococcus aureus, Escherichia coli and Candida albicans. The hydroxyapatite sample with the highest content of silver has shown the highest antimicrobial activity; killed all cells of E. coli and brought to more than 99% reduction in viable counts of S. aureus and C. albicans. The atomic force microscopic studies illustrate that silver-doped hydroxyapatite sample causes considerable morphological changes of microorganism cells which might be the cause of cells death. Hemolysis ratios of the silver-doped hydroxyapatite samples were below 3%, indicating good blood compatibility and that are promising as biomaterials. Crown Copyrighten
dc.publisherElsevier, Amsterdam
dc.relationMinistry of Science and Environmental Protection of the Republic of Serbia
dc.rightsrestrictedAccess
dc.sourceApplied Surface Science
dc.subjectHydroxyapatiteen
dc.subjectSilveren
dc.subjectAntimicrobialen
dc.subjectBoneen
dc.subjectHemolysisen
dc.subjectAFMen
dc.titleSynthesis of antimicrobial monophase silver-doped hydroxyapatite nanopowders for bone tissue engineeringen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractКрстић, Aлександра; Раицевић, Славица; Павловић, Мирјана С.; Митрић, Миодраг; Јанацковић, Ђорђе; Станић, Војислав; Јовановић, Драгољуб; Танасковић, Сладјана Б.; Димитријевић, Сузана;
dc.citation.volume257
dc.citation.issue9
dc.citation.spage4510
dc.citation.epage4518
dc.citation.other257(9): 4510-4518
dc.citation.rankM21
dc.identifier.wos000286459600114
dc.identifier.doi10.1016/j.apsusc.2010.12.113
dc.identifier.scopus2-s2.0-78951487082
dc.identifier.rcubconv_1759
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record