Thermal decomposition of new ruthenium(II) complexes containing N-alkylphenothiazines

Abstract

Thermal decomposition of chlorpromazine hydrochloride (CP center dot HCl), trifluoperazine dihydrochloride (TF center dot 2HCl) and thioridazine hydrochloride (TR center dot HCl), and the ruthenium complexes with dimethyl sulfoxide (dmso) of composition [RuCl(2)(dmso)(4)] and L[RuCl(3)(dmso)(3)]center dot xEtOH, L = CP center dot HCl, TF center dot 2HCl or TR center dot HCl is described. The phenothiazines are stable to temperature range of 200-280 A degrees C with an increasing stability order of TF center dot 2HCl < CP center dot HCl < TR center dot HCl. The decomposition of all the compounds takes place in superposing steps. For detection of chlorides and sulfides, EGD analysis was performed. The decomposition pattern of the complexes, due to their similar structure, is similar. The thermal data unambiguously resolve the contradiction between the elemental analysis and X-ray structural data for (TF center dot 2HCl)[RuCl(3)(dmso)(3)]Cl center dot EtOH. The compound crystallizes with one EtOH, evaporating in part at room temperature.