Effects of n-3 Supplementation on Plasma and Liver Phospholipid Fatty Acids Profile in Aged Wistar Rats
2011
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Аутори
Popović, TamaraBorozan, Sunčica
Arsić, Aleksandra
Debeljak-Martačić, Jasmina
Vucić, Vesna
de Luka, Silvio
Milovanović, Ivan
Trbović, Aleksandar
Glibetić, Maria
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The effects of fish oil supplementation in Wistar rats are focused on cardiovascular, endocrine, metabolic and antioxidant status changes. We determined plasma and liver phospholipid fatty acids (FAs) status and plasma lipid concentrations in aged Wistar rats. Our results showed differences in plasma and liver FAs profiles as well as plasma chlolesterol (CHOL), triglicerides (TG), high density lipoproteins (HDL), low density lipoproteins (LDL), CHOL/HDL ratio (risk factor for atherosclerosis) and LDL/HDL ratio (risk for cardiovascular diseases) between treated and control group of animals. In fish oil treated group there were statistically significant changes in FAs profile in increasing linoleic acid (LA), dihomo-gamma linoleic acid, eicopentanoic acid (EPA) and docosapentaenoic acid (DPA) and decreasing in arachidonic acid (AA) concentration. Also, liver phospholipids FAs results showed increasing concentrations of vascenic acid, LA, EPA, and DPA and decreasing concentration of AA af...ter supplementation of fish oil compared to control group. However, concentrations of CHOL, LDL and non HDL concentrations decreased while HDL increased in fish oil group. CHOL/HDL, LDL/HDL ratios decreased. These findings suggest that long term treatment of fish oil in aged Wistar rats can be beneficial in decreasing LDL, and decreasing risk factors for developing atherosclerosis and cardiovascular diseases. (doi: 10.5562/cca1751)
Кључне речи:
fish oil / aged rats / fatty acids / lipid statusИзвор:
Croatica Chemica Acta, 2011, 84, 1, 73-79Издавач:
- Croatian Chemical Soc, Zagreb
Финансирање / пројекти:
- Биолошки механизми, нутритивни унос и статус полинезасићених масних киселина и фолата: Унапређење исхране у Србији (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41030)
DOI: 10.5562/cca1751
ISSN: 0011-1643
WoS: 000292799300010
Scopus: 2-s2.0-79960203892
Колекције
Институција/група
Fakultet veterinarske medicineTY - JOUR AU - Popović, Tamara AU - Borozan, Sunčica AU - Arsić, Aleksandra AU - Debeljak-Martačić, Jasmina AU - Vucić, Vesna AU - de Luka, Silvio AU - Milovanović, Ivan AU - Trbović, Aleksandar AU - Glibetić, Maria PY - 2011 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/799 AB - The effects of fish oil supplementation in Wistar rats are focused on cardiovascular, endocrine, metabolic and antioxidant status changes. We determined plasma and liver phospholipid fatty acids (FAs) status and plasma lipid concentrations in aged Wistar rats. Our results showed differences in plasma and liver FAs profiles as well as plasma chlolesterol (CHOL), triglicerides (TG), high density lipoproteins (HDL), low density lipoproteins (LDL), CHOL/HDL ratio (risk factor for atherosclerosis) and LDL/HDL ratio (risk for cardiovascular diseases) between treated and control group of animals. In fish oil treated group there were statistically significant changes in FAs profile in increasing linoleic acid (LA), dihomo-gamma linoleic acid, eicopentanoic acid (EPA) and docosapentaenoic acid (DPA) and decreasing in arachidonic acid (AA) concentration. Also, liver phospholipids FAs results showed increasing concentrations of vascenic acid, LA, EPA, and DPA and decreasing concentration of AA after supplementation of fish oil compared to control group. However, concentrations of CHOL, LDL and non HDL concentrations decreased while HDL increased in fish oil group. CHOL/HDL, LDL/HDL ratios decreased. These findings suggest that long term treatment of fish oil in aged Wistar rats can be beneficial in decreasing LDL, and decreasing risk factors for developing atherosclerosis and cardiovascular diseases. (doi: 10.5562/cca1751) PB - Croatian Chemical Soc, Zagreb T2 - Croatica Chemica Acta T1 - Effects of n-3 Supplementation on Plasma and Liver Phospholipid Fatty Acids Profile in Aged Wistar Rats VL - 84 IS - 1 SP - 73 EP - 79 DO - 10.5562/cca1751 ER -
@article{ author = "Popović, Tamara and Borozan, Sunčica and Arsić, Aleksandra and Debeljak-Martačić, Jasmina and Vucić, Vesna and de Luka, Silvio and Milovanović, Ivan and Trbović, Aleksandar and Glibetić, Maria", year = "2011", abstract = "The effects of fish oil supplementation in Wistar rats are focused on cardiovascular, endocrine, metabolic and antioxidant status changes. We determined plasma and liver phospholipid fatty acids (FAs) status and plasma lipid concentrations in aged Wistar rats. Our results showed differences in plasma and liver FAs profiles as well as plasma chlolesterol (CHOL), triglicerides (TG), high density lipoproteins (HDL), low density lipoproteins (LDL), CHOL/HDL ratio (risk factor for atherosclerosis) and LDL/HDL ratio (risk for cardiovascular diseases) between treated and control group of animals. In fish oil treated group there were statistically significant changes in FAs profile in increasing linoleic acid (LA), dihomo-gamma linoleic acid, eicopentanoic acid (EPA) and docosapentaenoic acid (DPA) and decreasing in arachidonic acid (AA) concentration. Also, liver phospholipids FAs results showed increasing concentrations of vascenic acid, LA, EPA, and DPA and decreasing concentration of AA after supplementation of fish oil compared to control group. However, concentrations of CHOL, LDL and non HDL concentrations decreased while HDL increased in fish oil group. CHOL/HDL, LDL/HDL ratios decreased. These findings suggest that long term treatment of fish oil in aged Wistar rats can be beneficial in decreasing LDL, and decreasing risk factors for developing atherosclerosis and cardiovascular diseases. (doi: 10.5562/cca1751)", publisher = "Croatian Chemical Soc, Zagreb", journal = "Croatica Chemica Acta", title = "Effects of n-3 Supplementation on Plasma and Liver Phospholipid Fatty Acids Profile in Aged Wistar Rats", volume = "84", number = "1", pages = "73-79", doi = "10.5562/cca1751" }
Popović, T., Borozan, S., Arsić, A., Debeljak-Martačić, J., Vucić, V., de Luka, S., Milovanović, I., Trbović, A.,& Glibetić, M.. (2011). Effects of n-3 Supplementation on Plasma and Liver Phospholipid Fatty Acids Profile in Aged Wistar Rats. in Croatica Chemica Acta Croatian Chemical Soc, Zagreb., 84(1), 73-79. https://doi.org/10.5562/cca1751
Popović T, Borozan S, Arsić A, Debeljak-Martačić J, Vucić V, de Luka S, Milovanović I, Trbović A, Glibetić M. Effects of n-3 Supplementation on Plasma and Liver Phospholipid Fatty Acids Profile in Aged Wistar Rats. in Croatica Chemica Acta. 2011;84(1):73-79. doi:10.5562/cca1751 .
Popović, Tamara, Borozan, Sunčica, Arsić, Aleksandra, Debeljak-Martačić, Jasmina, Vucić, Vesna, de Luka, Silvio, Milovanović, Ivan, Trbović, Aleksandar, Glibetić, Maria, "Effects of n-3 Supplementation on Plasma and Liver Phospholipid Fatty Acids Profile in Aged Wistar Rats" in Croatica Chemica Acta, 84, no. 1 (2011):73-79, https://doi.org/10.5562/cca1751 . .