Genotoxicity and potential chemosterilant effects of Rosol
Article (Published version)
MetadataShow full item record
Rosol is an anticoagulant rodenticide which, according to the specification of its producer (VZ-Zemun), contains 0.5 g of warfarin-sodium in 100 mililiters of solution. Its cytogenetical effects on bone marrow mitotic cells and testicular meiotic cells of Mus musculus L. (1758) of the BALB/c strain were investigated in an in vivo experiment. Animals were intragastrically treated with Rosol at doses of 0,25 mg, 0,50 mg and 0,75 mg of warfarin-sodium/kg b. w. The applied doses of warfarin-sodium were chosen according to the results of Kastori (1993), who found 0,562 mg anticoagulant rodenticides could be detected in 1 kg of soil polluted by various pesticides. The investigated doses of Rosol induced numerical (polyploidy and aneuploidy) and structural chromosomal changes (lesions, gaps, acentrics, Robertsonian fusions) of both cell types. The results obtained in the experiment point to genotoxic and mutagenic effects of Rosol or of its active component, warfarin-sodium. These effects are... significant for rodent pest control as they might cause fertility failure of the treated rodents. The occurrence of numerical and structural chromosomal changes in testicular meiotic cells could lead to the production of genetically unbalanced gametes. If the unbalanced products mature and are capable of fertilization, unbalanced zygotes will be formed and may die in utero or give rise to congenitally abnormal offspring. It appears that the anticoagulant rodenticide Rosol causes antifertile effects and also acts as a chemosterilant.
Keywords:Rosol / warfarin-sodium / mice / chromosomal changes / genotoxicity / chemosterilant
Source:Acta veterinaria - Beograd, 1997, 47, 4, 237-245
- Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd