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dc.creatorStanimirović, Zoran
dc.creatorVučinić, Marijana
dc.creatorSoldatović, Bogosav
dc.creatorMarković, B
dc.date.accessioned2020-06-03T12:36:56Z
dc.date.available2020-06-03T12:36:56Z
dc.date.issued1997
dc.identifier.issn0567-8315
dc.identifier.urihttps://vet-erinar.vet.bg.ac.rs/handle/123456789/80
dc.description.abstractRosol is an anticoagulant rodenticide which, according to the specification of its producer (VZ-Zemun), contains 0.5 g of warfarin-sodium in 100 mililiters of solution. Its cytogenetical effects on bone marrow mitotic cells and testicular meiotic cells of Mus musculus L. (1758) of the BALB/c strain were investigated in an in vivo experiment. Animals were intragastrically treated with Rosol at doses of 0,25 mg, 0,50 mg and 0,75 mg of warfarin-sodium/kg b. w. The applied doses of warfarin-sodium were chosen according to the results of Kastori (1993), who found 0,562 mg anticoagulant rodenticides could be detected in 1 kg of soil polluted by various pesticides. The investigated doses of Rosol induced numerical (polyploidy and aneuploidy) and structural chromosomal changes (lesions, gaps, acentrics, Robertsonian fusions) of both cell types. The results obtained in the experiment point to genotoxic and mutagenic effects of Rosol or of its active component, warfarin-sodium. These effects are significant for rodent pest control as they might cause fertility failure of the treated rodents. The occurrence of numerical and structural chromosomal changes in testicular meiotic cells could lead to the production of genetically unbalanced gametes. If the unbalanced products mature and are capable of fertilization, unbalanced zygotes will be formed and may die in utero or give rise to congenitally abnormal offspring. It appears that the anticoagulant rodenticide Rosol causes antifertile effects and also acts as a chemosterilant.en
dc.publisherUniverzitet u Beogradu - Fakultet veterinarske medicine, Beograd
dc.rightsrestrictedAccess
dc.sourceActa Veterinaria-Beograd
dc.subjectRosolen
dc.subjectwarfarin-sodiumen
dc.subjectmiceen
dc.subjectchromosomal changesen
dc.subjectgenotoxicityen
dc.subjectchemosterilanten
dc.titleGenotoxicity and potential chemosterilant effects of Rosolen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСтанимировић, Зоран; Солдатовић, Богосав; Марковић, Б; Вучинић, Маријана;
dc.citation.volume47
dc.citation.issue4
dc.citation.spage237
dc.citation.epage245
dc.citation.other47(4): 237-245
dc.identifier.wosA1997XX16500007
dc.identifier.scopus2-s2.0-0346998838
dc.identifier.rcubhttps://hdl.handle.net/21.15107/rcub_veterinar_80
dc.type.versionpublishedVersion


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