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Treatment for production of interferon-alpha (ifn-α) and interferon-gamma (ifn-γ) from the same purified suspension of leukocytes
dc.creator | Stanković, B. | |
dc.creator | Surbatović, M. | |
dc.creator | Stojanović, G. | |
dc.creator | Mihajlović, M. | |
dc.creator | Tambur, Zoran | |
dc.creator | Kulišić, Zoran | |
dc.creator | Marković, M. | |
dc.date.accessioned | 2020-06-03T13:29:41Z | |
dc.date.available | 2020-06-03T13:29:41Z | |
dc.date.issued | 2011 | |
dc.identifier.issn | 1992-2248 | |
dc.identifier.uri | https://vet-erinar.vet.bg.ac.rs/handle/123456789/826 | |
dc.description.abstract | The basic aim of this work was to examine possibilities for introducing a new biotechnological treatment for preparation, storage and further purifying the suspension of leukocytes ("buffy coat" (BC)), intended for production of human interferon-alpha (hIFN-hIFN-α) and human interferon-gamma (hIFN-γ). Three hundred and eighty four units of BC were examined. They were divided into three series of 128 BC units each - one control series (KSBC) and two experimental series to which 10% dextran solution (ESBC-I) or 6% hydroxyethyl starch solution (ESBC-II) were added. The lowest titer (297929 IU) of hIFN-α ensued from KSBC, a higher titer from ESBC-I (317184 IU) and the highest titer from ESBC-II (364406 IU). We also found that the lowest hIFN- γ titer was produced from KSBC (48142 IU), a somewhat larger one from ESBC-I (67571 IU), and the highest titer was obtained from ESBC-II (73428. IU). This study has demonstrated the positive influence of modified biotechnological treatments on the production of hIFN-α and hIFN- γ from BC. | en |
dc.rights | restrictedAccess | |
dc.source | Scientific Research and Essays | |
dc.subject | Biotechnological treatment | en |
dc.subject | Buffy coat | en |
dc.subject | Interferon-alpha | en |
dc.subject | Interferon-gamma | en |
dc.title | Treatment for production of interferon-alpha (ifn-α) and interferon-gamma (ifn-γ) from the same purified suspension of leukocytes | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Тамбур, Зоран; Станковић, Б.; Кулишић, Зоран; Сурбатовић, М.; Стојановић, Г.; Михајловић, М.; Марковић, М.; | |
dc.citation.volume | 6 | |
dc.citation.issue | 7 | |
dc.citation.spage | 1522 | |
dc.citation.epage | 1529 | |
dc.citation.other | 6(7): 1522-1529 | |
dc.citation.rank | M23 | |
dc.identifier.scopus | 2-s2.0-79958021194 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_veterinar_826 | |
dc.type.version | publishedVersion |