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Ispitivanje podnošljivosti produžene peroralne primene eugenola kod pacova

dc.creatorJezdimirović, Milanka
dc.creatorAleksić, Nevenka
dc.creatorTrailović, Saša
dc.creatorIvanović, Saša
dc.creatorJezdimirović, Nemanja
dc.date.accessioned2020-06-03T13:32:08Z
dc.date.available2020-06-03T13:32:08Z
dc.date.issued2012
dc.identifier.issn0350-2457
dc.identifier.urihttp://vet-erinar.vet.bg.ac.rs/handle/123456789/862
dc.description.abstractThe potential toxicity and general tolerability of eugenol following two-week or four-week continuous p.o. administration to rats has been investigated. An experiment was performed on 72 male rats of the Wistar strain. Four groups of rats were treated with different doses of eugenol (10 mg/kg bm/day, 50 mg/kg, 200 mg/kg and 400 mg/kg bm/day), the fifth group was administered vehicle (0.5 % methylcellulose, propylene glycol and water), and the sixth group comprised absolutely untreated controls. The corresponding doses of eugenol and vehicle were applied using a gastric probe in a volume of 1 ml/100 g body mass. The general tolerability of eugenol was evaluated on the basis of the daily intake of water and food, body mass, general health condition, behaviour, and lethality in the course of the experiment. In the investigated doses, eugenol applied p.o. in the course of two or four weeks does not influence significantly the intake of food, water, or body mass of rats. The dose of 400 mg/kg/day produced undesired reactions (agitation and hyperesthesia) that were first observed on day 21 and lasted until the end of the experiment. Low subacute toxicity of eugenol was established following p.o. administration to rats. Eugenol in doses of 200 and 400 mg/kg tm/day has a low toxic potential and is safe for administration to this animal species.en
dc.description.abstractIspitivana je potencijalna toksičnost, odnosno opšta podnošljivost eugenola posle dvonedeljne i četvoronedeljne kontinuirane p.o. primene. Ogled je izveden na 72 mužjaka pacova soja vistar. Četiri grupe pacova tretirane su različitim dozama eugenola (10 mg/kg tm/dan, 50 mg/kg, 200 mg/kg i 400 mg/kg tm/dan), peta grupa dobijala je vehikulum (0,5 % metil-celuloza, propilen-glikol i voda), a šesta je bila kontrolna grupa. Odgovarajuće doze eugenola i vehikuluma aplikovane su gastričnom sondom u volumenu od 1 ml/100 g telesne mase. Opšta podnošljivost eugenola procenjivana je na osnovu dnevnog unosa vode i hrane, telesne mase, opšteg zdravstvenog stanja, ponaš anja i letaliteta tokom ogleda. U ispitivanim dozama eugenol primenjivan p.o. tokom dve ili četiri nedelje ne utiče značajno na unos hrane, vode i telesnu masu pacova. Doza od 400 mg/kg/dan dovela je do neželjenih reakcija (uznemirenost i hiperestezija) koje su prvi put zapažene 21. dana i trajale su do kraja ogleda. Ustanovljena je niska subakutna toksičnost eugenola posle p.o. primene kod pacova. Doze eugenola od 200 i 400 mg/kg tm/dan imaju nizak toksični potencijal i bezbedne su za primenu kod ove vrste životinja.sr
dc.publisherUniverzitet u Beogradu - Fakultet veterinarske medicine, Beograd
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46009/RS//
dc.rightsopenAccess
dc.sourceVeterinarski glasnik
dc.subjecteugenolen
dc.subjecttoxicityen
dc.subjectraten
dc.subjectfood and water intakeen
dc.subjecteugenolsr
dc.subjecttoksičnostsr
dc.subjectpacovsr
dc.subjectunos hrane i vodesr
dc.titleThe assessment of tolerability of prolonged oral eugenol administration in ratsen
dc.titleIspitivanje podnošljivosti produžene peroralne primene eugenola kod pacovasr
dc.typearticle
dc.rights.licenseBY
dcterms.abstractЈездимировић, Миланка; Траиловић, Саша; Јездимировић, Немања; Ивановић, Саша; Aлексић, Невенка; Испитивање подношљивости продужене пероралне примене еугенола код пацова; Испитивање подношљивости продужене пероралне примене еугенола код пацова;
dc.citation.volume66
dc.citation.issue3-4
dc.citation.spage185
dc.citation.epage197
dc.citation.other66(3-4): 185-197
dc.citation.rankM24
dc.identifier.doi10.2298/VETGL1204185J
dc.identifier.fulltexthttp://veterinar.vet.bg.ac.rs/bitstream/id/1394/861.pdf
dc.identifier.rcubconv_276
dc.type.versionpublishedVersion


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