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dc.creatorRasic-Milutinović, Zorica
dc.creatorPopović, Tamara
dc.creatorPeruničić-Peković, Gordana
dc.creatorArsić, Aleksandra
dc.creatorBorozan, Sunčica
dc.creatorGlibetić, Marija
dc.date.accessioned2020-06-03T13:33:14Z
dc.date.available2020-06-03T13:33:14Z
dc.date.issued2012
dc.identifier.issn0188-4409
dc.identifier.urihttp://vet-erinar.vet.bg.ac.rs/handle/123456789/878
dc.description.abstractBackground. Serum paraoxonase-1(PON-1) activity is decreased in clinical conditions associated with low high-density lipoprotein cholesterol (HDL-C), increased lipid peroxidation and low-grade chronic inflammation, as in type 2 diabetes mellitus (T2DM). Until now there are no data about the association of any fatty acid (FA) with PON-1 activity in T2DM. Methods. Twenty patients with T2DM and 16 healthy controls were included in this cross-sectional study. Serum PON-1 activity, superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) activity as well as plasma glucose, HbA1c, lipids, high-sensitivity C-reactive protein (hs-CRP) and insulin resistance, homeostasis model assessment (HOMA-IR) were measured. The preparation of FA methyl esters and their gas chromatography (GC) analysis were also performed. Results. HbA1c, plasma insulin, HOMA-IR and triglycerides were higher in patients with T2DM, whereas HDL-C was lower in those subjects. Levels of pro-oxidative enzyme malondialdehyde (MDA) and hs-CRP were significantly higher, and antioxidative enzymes SOD and PON-1 activity were decreased in T2DM patients. N-6 PUFAs were higher in T2DM patients, particularly linoleic acid (LA, 18:2 n-6) and arachidonic acid (AA, 20:4 n-6), whereas n-3 PUFA, docosahexaenoic acid (DHA, 22:6 n-3) was lower in T2DM patients. Using regression analysis, we have shown that only LA and DHA independently predicted PON-1 activity of all participants, particularly in patients with T2DM. Conclusions. Decreased serum PON-1 activity may, in part, be influenced by higher levels of LA and lower levels of DHA in patients with 12DM. Prospective, randomized studies are necessary to confirm these preliminary findings.en
dc.publisherElsevier Science Inc, New York
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41030/RS//
dc.rightsrestrictedAccess
dc.sourceArchives of Medical Research
dc.subjectType 2 diabetes mellitusen
dc.subjectParaoxonase-1 activityen
dc.subjectChronic inflammationen
dc.subjectPolyunsaturated fatty acidsen
dc.titleLower Serum Paraoxonase-1 Activity Is Related to Linoleic and Docosahexanoic Fatty Acids in Type 2 Diabetic Patientsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractГлибетић, Марија; Поповић, Тамара; Борозан, Сунчица; Aрсић, Aлександра; Перуничић-Пековић, Гордана; Расиц-Милутиновић, Зорица;
dc.citation.volume43
dc.citation.issue1
dc.citation.spage75
dc.citation.epage82
dc.citation.other43(1): 75-82
dc.citation.rankM22
dc.identifier.wos000303429400011
dc.identifier.doi10.1016/j.arcmed.2011.12.008
dc.identifier.pmid22222492
dc.identifier.scopus2-s2.0-84859219589
dc.identifier.rcubconv_1833
dc.type.versionpublishedVersion


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