dc.creator | Rasic-Milutinović, Zorica | |
dc.creator | Popović, Tamara | |
dc.creator | Peruničić-Peković, Gordana | |
dc.creator | Arsić, Aleksandra | |
dc.creator | Borozan, Sunčica | |
dc.creator | Glibetić, Marija | |
dc.date.accessioned | 2020-06-03T13:33:14Z | |
dc.date.available | 2020-06-03T13:33:14Z | |
dc.date.issued | 2012 | |
dc.identifier.issn | 0188-4409 | |
dc.identifier.uri | https://vet-erinar.vet.bg.ac.rs/handle/123456789/878 | |
dc.description.abstract | Background. Serum paraoxonase-1(PON-1) activity is decreased in clinical conditions associated with low high-density lipoprotein cholesterol (HDL-C), increased lipid peroxidation and low-grade chronic inflammation, as in type 2 diabetes mellitus (T2DM). Until now there are no data about the association of any fatty acid (FA) with PON-1 activity in T2DM. Methods. Twenty patients with T2DM and 16 healthy controls were included in this cross-sectional study. Serum PON-1 activity, superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) activity as well as plasma glucose, HbA1c, lipids, high-sensitivity C-reactive protein (hs-CRP) and insulin resistance, homeostasis model assessment (HOMA-IR) were measured. The preparation of FA methyl esters and their gas chromatography (GC) analysis were also performed. Results. HbA1c, plasma insulin, HOMA-IR and triglycerides were higher in patients with T2DM, whereas HDL-C was lower in those subjects. Levels of pro-oxidative enzyme malondialdehyde (MDA) and hs-CRP were significantly higher, and antioxidative enzymes SOD and PON-1 activity were decreased in T2DM patients. N-6 PUFAs were higher in T2DM patients, particularly linoleic acid (LA, 18:2 n-6) and arachidonic acid (AA, 20:4 n-6), whereas n-3 PUFA, docosahexaenoic acid (DHA, 22:6 n-3) was lower in T2DM patients. Using regression analysis, we have shown that only LA and DHA independently predicted PON-1 activity of all participants, particularly in patients with T2DM. Conclusions. Decreased serum PON-1 activity may, in part, be influenced by higher levels of LA and lower levels of DHA in patients with 12DM. Prospective, randomized studies are necessary to confirm these preliminary findings. | en |
dc.publisher | Elsevier Science Inc, New York | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41030/RS// | |
dc.rights | restrictedAccess | |
dc.source | Archives of Medical Research | |
dc.subject | Type 2 diabetes mellitus | en |
dc.subject | Paraoxonase-1 activity | en |
dc.subject | Chronic inflammation | en |
dc.subject | Polyunsaturated fatty acids | en |
dc.title | Lower Serum Paraoxonase-1 Activity Is Related to Linoleic and Docosahexanoic Fatty Acids in Type 2 Diabetic Patients | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Глибетић, Марија; Поповић, Тамара; Борозан, Сунчица; Aрсић, Aлександра; Перуничић-Пековић, Гордана; Расиц-Милутиновић, Зорица; | |
dc.citation.volume | 43 | |
dc.citation.issue | 1 | |
dc.citation.spage | 75 | |
dc.citation.epage | 82 | |
dc.citation.other | 43(1): 75-82 | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000303429400011 | |
dc.identifier.doi | 10.1016/j.arcmed.2011.12.008 | |
dc.identifier.pmid | 22222492 | |
dc.identifier.scopus | 2-s2.0-84859219589 | |
dc.type.version | publishedVersion | |