Cytogenetic changes in bone marrow cells of wistar rats induced by levamisole hydrochloride
Апстракт
"Levamisol" is an antiparasitic drug produced by ICN-Galenika (Yugoslavia). This anthelmintic was cytogenetically analyzed in vivo in an experiment on three groups of Wistar rats. The control group of rats was treated with saline. Experimental animals were injected intraperitoneally with two therapeutic doses of the anthelmintic (2,2 mg levamisole hydrochloride/kg b. w. and 4,4 mg levamisole hydrochloride/kg b.w.) during a seven day treatment period. Cytogenetic changes of bone marrow cells were evaluated by determination of their mitotic index, as well as structural and numerical chromosomal aberrations. Both tested doses of the anthelmintic induced an increase of mitotic index, aneuploidy, polyploidy and structural chromosomal changes of the break and insertion type of lesion. Insertions were observed on the first pair of autosomes.
Кључне речи:
levamisole hydrochloride / Wistar rats / cytogenetic changes / bone marrow cells / insertion ls [q21-q22]Извор:
Acta Veterinaria-Beograd, 1998, 48, 4, 255-262Издавач:
- Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
Колекције
Институција/група
Fakultet veterinarske medicineTY - JOUR AU - Stanimirović, Zoran AU - Vučinić, Marijana AU - Soldatović, Bogosav PY - 1998 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/90 AB - "Levamisol" is an antiparasitic drug produced by ICN-Galenika (Yugoslavia). This anthelmintic was cytogenetically analyzed in vivo in an experiment on three groups of Wistar rats. The control group of rats was treated with saline. Experimental animals were injected intraperitoneally with two therapeutic doses of the anthelmintic (2,2 mg levamisole hydrochloride/kg b. w. and 4,4 mg levamisole hydrochloride/kg b.w.) during a seven day treatment period. Cytogenetic changes of bone marrow cells were evaluated by determination of their mitotic index, as well as structural and numerical chromosomal aberrations. Both tested doses of the anthelmintic induced an increase of mitotic index, aneuploidy, polyploidy and structural chromosomal changes of the break and insertion type of lesion. Insertions were observed on the first pair of autosomes. PB - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd T2 - Acta Veterinaria-Beograd T1 - Cytogenetic changes in bone marrow cells of wistar rats induced by levamisole hydrochloride VL - 48 IS - 4 SP - 255 EP - 262 UR - https://hdl.handle.net/21.15107/rcub_veterinar_90 ER -
@article{ author = "Stanimirović, Zoran and Vučinić, Marijana and Soldatović, Bogosav", year = "1998", abstract = ""Levamisol" is an antiparasitic drug produced by ICN-Galenika (Yugoslavia). This anthelmintic was cytogenetically analyzed in vivo in an experiment on three groups of Wistar rats. The control group of rats was treated with saline. Experimental animals were injected intraperitoneally with two therapeutic doses of the anthelmintic (2,2 mg levamisole hydrochloride/kg b. w. and 4,4 mg levamisole hydrochloride/kg b.w.) during a seven day treatment period. Cytogenetic changes of bone marrow cells were evaluated by determination of their mitotic index, as well as structural and numerical chromosomal aberrations. Both tested doses of the anthelmintic induced an increase of mitotic index, aneuploidy, polyploidy and structural chromosomal changes of the break and insertion type of lesion. Insertions were observed on the first pair of autosomes.", publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd", journal = "Acta Veterinaria-Beograd", title = "Cytogenetic changes in bone marrow cells of wistar rats induced by levamisole hydrochloride", volume = "48", number = "4", pages = "255-262", url = "https://hdl.handle.net/21.15107/rcub_veterinar_90" }
Stanimirović, Z., Vučinić, M.,& Soldatović, B.. (1998). Cytogenetic changes in bone marrow cells of wistar rats induced by levamisole hydrochloride. in Acta Veterinaria-Beograd Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 48(4), 255-262. https://hdl.handle.net/21.15107/rcub_veterinar_90
Stanimirović Z, Vučinić M, Soldatović B. Cytogenetic changes in bone marrow cells of wistar rats induced by levamisole hydrochloride. in Acta Veterinaria-Beograd. 1998;48(4):255-262. https://hdl.handle.net/21.15107/rcub_veterinar_90 .
Stanimirović, Zoran, Vučinić, Marijana, Soldatović, Bogosav, "Cytogenetic changes in bone marrow cells of wistar rats induced by levamisole hydrochloride" in Acta Veterinaria-Beograd, 48, no. 4 (1998):255-262, https://hdl.handle.net/21.15107/rcub_veterinar_90 .