In vivo MRI biocompatibility evaluation of functionalized carbon fibers in reaction with soft tissues

Abstract

In modern medicine implants are very important and so is their design and choice of materials. Almost equally important is the choice of imaging technique used to in vivo monitor their fate and biocompatibility. The aim of this study was to evaluate the ability of magnetic resonance imaging (MRI) in monitoring the biocompatibility of two newly designed carbon fibers. We have analyzed the interaction of surface functionalized carbon fibers (basic and acidic) with muscle and subcutaneous tissues of rabbits. MRI techniques showed to be useful in longitudinal monitoring of the surrounding tissues, assessment of biocompatibility of new implants, and in the distinction of in vivo surgical edema from inflammation. Histopathology confirmed MRI results, thus showing that MRI has a great potential for in vivo studies of such materials.

U modernoj medicine implanti su veoma važni, kao i njihovo dizajniranje i izbor materijala. Isto tako je značajan i izbor tehnike kojom se prati in vivo njihova sudbina i biokompatibilnost. Cilj ove studije je bila procena mogućnosti praćenja biokompatibilnosti dva novo dizajnirana karbonska vlakna pomoću magnetic resonance imaging (MRI). Analizirali smo interakciju karbonskih vlakana sa funkcionalizovanom površinom (kiselinom i bazom) sa mišićnim i potkožnim tkivom kunića. MRI tehnika se pokazala uspešnom u toku praćenja reakcije okolnog tkiva, i procene biokompatibilnosti nove vrste implanata, jer je uspela da in vivo odvoji hirurški edem od inflamacije. Patohistološka analiza je potvrdila rezultate MRI pokazujući time da MRI ima veliki potencijal za in vivo studije takvih materijala.