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dc.creatorKosić-Spasojević, Ljubica
dc.creatorTrailović, Dragiša
dc.creatorMatunović, Radomir
dc.date.accessioned2020-06-03T13:36:57Z
dc.date.available2020-06-03T13:36:57Z
dc.date.issued2012
dc.identifier.issn0034-5288
dc.identifier.urihttp://vet-erinar.vet.bg.ac.rs/handle/123456789/932
dc.description.abstractStudies of clinical uses of brain natriuretic peptide (BNP) represent one of the most important advances in cardiology since the introduction of echocardiography as a clinical diagnostic procedure. Defining the clinical potential of BNP in canine cardiology has not been completed yet. The aim of this study is to measure BNP concentrations in healthy German Shepherd dogs of different ages as a baseline in resting and when conventional protocol of the dobutamine stress test (DST) is applied to dogs. Concentrations of BNP were measured in blood serum by the radioimmunoassay method. The values of BNP concentrations were compared to cardiac parameters obtained by standard cardiac diagnostic procedures (radiology, electrocardiography and echocardiography). No significant differences in serum BNP concentrations existed in dogs of different ages. A statistically significant increase in BNP concentrations was registered after DST. These changes in BNP concentrations were related to ST/T electrocardiographic changes, and correlated to changes in the left ventricular internal diameter in systole (LVESD). These data suggest that BNP is not increased in aged dogs with normal cardiac systolic function and renal function, and that myocardial ischemia leads to a significant increase in BNP concentrations even in dogs with normal left ventricular function.en
dc.publisherElsevier Sci Ltd, Oxford
dc.rightsrestrictedAccess
dc.sourceResearch in Veterinary Science
dc.subjectBNPen
dc.subjectGerman Shepherd dogsen
dc.subjectDSTen
dc.subjectIschemiaen
dc.titleResting and dobutamine stress test induced serum concentrations of brain natriuretic peptide in German Shepherd dogsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМатуновић, Радомир; Траиловић, Драгиша; Косић-Спасојевић, Љубица;
dc.citation.volume93
dc.citation.issue3
dc.citation.spage1446
dc.citation.epage1453
dc.citation.other93(3): 1446-1453
dc.citation.rankM21
dc.identifier.wos000311185900061
dc.identifier.doi10.1016/j.rvsc.2012.04.002
dc.identifier.pmid22537461
dc.identifier.scopus2-s2.0-84866862167
dc.identifier.rcubconv_1862
dc.type.versionpublishedVersion


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